MEF2C ELISA Kit for Human(Homo sapiens) | EIAab.comMEF2C ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MEF2C(Gene name) > Human

MEF2C (Gene name),

Myocyte-specific enhancer factor 2C (Protein name ), MEF2C_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MEF2C;

Protein name:

Myocyte-specific enhancer factor 2C;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation. Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4, HDAC7 AND HDAC9; the interaction WITH HDACs represses transcriptional activity. Interacts with MYOCD.

Function:

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

473

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

473:

RPSPDERESP | SVKRMRLSEG | WAT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.649965

STRING:

9606.ENSP00000396219

KEGG:

hsa:4208

Pfam:

PF12347

String:

Q06413

SMR:

Q06413

MIM:

600662

Uniprot:

Q06413

FOR

ELISA Kit for Human Myocyte-specific enhancer factor 2C

CLIA Kit for Human Myocyte-specific enhancer factor 2C

Polyclonal Antibody for Human Myocyte-specific enhancer factor 2C

Monoclonal Antibody for Human Myocyte-specific enhancer factor 2C

Protein for Human Myocyte-specific enhancer factor 2C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex."
Leifer D. , Krainc D. , Yu Y.-T. , McDermott J. , Breitbart R.E. , Heng J. , Neve R.L. , Kosofsky B. , Nadal-Ginard B. , Lipton S.A.
Proc. Natl. Acad. Sci. U.S.A.90:1546-1550(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
tissue: Fetal brain.
tissue: Muscle.
2.

"hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors."
McDermott J.C. , Cardoso M.C. , Yu Y.-T. , Andres V. , Leifer D. , Krainc D. , Lipton S.A. , Nadal-Ginard B.
Mol. Cell. Biol.13:2564-2577(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Skeletal muscle.
3.

"Identification and characterization of a new splice variant of human MEF2C."
Infantino V. , Convertini P. , Palmieri F. , Iacobazzi V.
Submitted (2008-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
tissue: Skeletal muscle.
4.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6)
tissue: Skeletal muscle.
5.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C."
Kato Y. , Kravchenko V.V. , Tapping R.I. , Han J. , Ulevitch R.J. , Lee J.-D.
EMBO J.16:7054-7066(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-293; THR-300 AND SER-419;FUNCTION;MUTAGENESIS OF THR-293; THR-300 AND SER-419
7.

"Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation."
Han J. , Jiang Y. , Li Z. , Kravchenko V.V. , Ulevitch R.J.
Nature386:296-299(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-293; THR-300 AND SER-419;FUNCTION;MUTAGENESIS OF THR-293; THR-300 AND SER-419
8.

"Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes."
Swanson B.J. , Jaeck H.-M. , Lyons G.E.
Mol. Immunol.35:445-458(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
9.

"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor."
Wang A.H. , Bertos N.R. , Vezmar M. , Pelletier N. , Crosato M. , Heng H.H. , Th'ng J. , Han J. , Yang X.-J.
Mol. Cell. Biol.19:7816-7827(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC4
10.

"Big mitogen-activated kinase regulates multiple members of the MEF2 protein family."
Kato Y. , Zhao M. , Morikawa A. , Sugiyama T. , Chakravortty D. , Koide N. , Yoshida T. , Tapping R.I. , Yang Y. , Yokochi T. , Lee J.D.
J. Biol. Chem.275:18534-18540(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY MAPK7
11.

"Cloning and characterization of a histone deacetylase, HDAC9."
Zhou X. , Marks P.A. , Rifkind R.A. , Richon V.M.
Proc. Natl. Acad. Sci. U.S.A.98:10572-10577(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC9
12.

"Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis."
Okamoto S. , Li Z. , Ju C. , Scholzke M.N. , Mathews E. , Cui J. , Salvesen G.S. , Bossy-Wetzel E. , Lipton S.A.
Proc. Natl. Acad. Sci. U.S.A.99:3974-3979(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING AT ASP-432;FUNCTION;MUTAGENESIS OF ASP-432
13.

"Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity."
Zhu B. , Gulick T.
Mol. Cell. Biol.24:8264-8275(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-396;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF SER-396;FUNCTION OF ISOFORMS
14.

"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
Gocke C.B. , Yu H. , Kang J.
J. Biol. Chem.280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION
15.

"Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain."
Zhu B. , Ramachandran B. , Gulick T.
J. Biol. Chem.280:28749-28760(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF BETA DOMAIN;MUTAGENESIS OF SER-271; GLU-272; ASP-273; ASP-275; SER-387 AND SER-396
16.

"Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors."
Gregoire S. , Yang X.-J.
Mol. Cell. Biol.25:2273-2287(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-391
17.

"Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation."
Ma K. , Chan J.K. , Zhu G. , Wu Z.
Mol. Cell. Biol.25:3575-3582(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-116; LYS-119; LYS-234; LYS-239; LYS-252 AND LYS-264;INTERACTION WITH EP300;FUNCTION;DNA-BINDING;MUTAGENESIS OF LYS-116; LYS-119; LYS-234; LYS-239; LYS-252 AND LYS-264
18.

"Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity."
Kang J. , Gocke C.B. , Yu H.
BMC Biochem.7:5-5(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-391;MUTAGENESIS OF LYS-391 AND SER-396
19.

"MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations."
Le Meur N. , Holder-Espinasse M. , Jaillard S. , Goldenberg A. , Joriot S. , Amati-Bonneau P. , Guichet A. , Barth M. , Charollais A. , Journel H. , Auvin S. , Boucher C. , Kerckaert J.P. , David V. , Manouvrier-Hanu S. , Saugier-Veber P. , Frebourg T. , Dubourg C. , more...
J. Med. Genet.47:22-29(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MRD20

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