MEN1 ELISA Kit for Human(Homo sapiens) | EIAab.comMEN1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MEN1(Gene name) > Human

MEN1 (Gene name),

Menin (Protein name ), MEN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MEN1(SCG2);

Protein name:

Menin;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms. Interacts with FANCD2 and DBF4. Interacts with JUND. Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA.

Function:

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

Subcellular Location:

Nucleus Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.

Protein Attributes:

Sequence length:

615

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

615:

SDYTLSFLKR | QRKGL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000337088

KEGG:

hsa:4221

SMR:

O00255

UniGene:

Hs.423348

MIM:

131100

String:

O00255

Pfam:

PF05053

Uniprot:

O00255

FOR

ELISA Kit for Human Menin

CLIA Kit for Human Menin

Polyclonal Antibody for Human Menin

Monoclonal Antibody for Human Menin

Protein for Human Menin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Positional cloning of the gene for multiple endocrine neoplasia-type 1."
Chandrasekharappa S.C. , Guru S.C. , Manickam P. , Olufemi S.-E. , Collins F.S. , Emmert-Buck M.R. , Debelenko L.V. , Zhuang Z. , Lubensky I.A. , Liotta L.A. , Crabtree J.S. , Wang Y. , Roe B.A. , Weisemann J. , Boguski M.S. , Agarwal S.K. , Kester M.B. , Kim Y.S. , more...
Science276:404-407(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);VARIANTS MEN1 ARG-22; LYS-119 DEL; GLU-368 DEL AND ARG-441;VARIANTS GLN-176 AND ALA-546
tissue: Leukocyte.
2.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"Novel MEN1 germline mutations in Brazilian families with multiple endocrine neoplasia type 1."
Toledo R.A. , Lourenco D.M. , Coutinho F.L. , Quedas E. , Mackowiack I. , Machado M.C. , Montenegro F. , Cunha-Neto M.B. , Liberman B. , Pereira M.A. , Correa P.H. , Toledo S.P.
Clin. Endocrinol. (Oxf.)67:377-384(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2);VARIANTS MEN1 89-LEU--ALA-95 DEL; PHE-147; ARG-418; PRO-419 AND CYS-476;VARIANT ALA-546
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ALA-546
tissue: Placenta.
tissue: Uterus.
5.

"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription."
Agarwal S.K. , Guru S.C. , Heppner C. , Erdos M.R. , Collins R.M. , Park S.Y. , Saggar S. , Chandrasekharappa S.C. , Collins F.S. , Spiegel A.M. , Marx S.J. , Burns A.L.
Cell96:143-152(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JUND;VARIANTS MEN1 LEU-12; ARG-22; ASP-139; TYR-139; PRO-165; PRO-181; VAL-247; PRO-291; PRO-314; ARG-349 AND ARG-441
6.

"The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation."
Heppner C. , Bilimoria K.Y. , Agarwal S.K. , Kester M. , Whitty L.J. , Guru S.C. , Chandrasekharappa S.C. , Collins F.S. , Spiegel A.M. , Marx S.J. , Burns A.L.
Oncogene20:4917-4925(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFKB1; NFKB2 AND RELA
7.

"Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling."
Kaji H. , Canaff L. , Lebrun J.J. , Goltzman D. , Hendy G.N.
Proc. Natl. Acad. Sci. U.S.A.98:3837-3842(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMAD3
8.

"Menin associates with FANCD2, a protein involved in repair of DNA damage."
Jin S. , Mao H. , Schnepp R.W. , Sykes S.M. , Silva A.C. , D'Andrea A.D. , Hua X.
Cancer Res.63:4204-4210(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH FANCD2
9.

"Multiple tumor suppressor pathways negatively regulate telomerase."
Lin S.Y. , Elledge S.J.
Cell113:881-889(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TERT REPRESSION
10.

"Functional interaction between tumor suppressor menin and activator of S-phase kinase."
Schnepp R.W. , Hou Z. , Wang H. , Petersen C. , Silva A. , Masai H. , Hua X.
Cancer Res.64:6791-6796(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DBF4
11.

"Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus."
Hughes C.M. , Rozenblatt-Rosen O. , Milne T.A. , Copeland T.D. , Levine S.S. , Lee J.C. , Hayes D.N. , Shanmugam K.S. , Bhattacharjee A. , Biondi C.A. , Kay G.F. , Hayward N.K. , Hess J.L. , Meyerson M.
Mol. Cell13:587-597(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN H3K4 METHYLATION;IDENTIFICATION IN THE MEN1-ASSOCIATED HISTONE METHYLTRANSFERASE COMPLEX;INTERACTION WITH POLR2A AND POLR2B;VARIANTS MEN1 LEU-12; ARG-22; ASP-139; VAL-247; PRO-314; ARG-349 AND ARG-441
12.

"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."
Yokoyama A. , Wang Z. , Wysocka J. , Sanyal M. , Aufiero D.J. , Kitabayashi I. , Herr W. , Cleary M.L.
Mol. Cell. Biol.24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MLL-HCF COMPLEX
13.

"PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."
Cho Y.-W. , Hong T. , Hong S. , Guo H. , Yu H. , Kim D. , Guszczynski T. , Dressler G.R. , Copeland T.D. , Kalkum M. , Ge K.
J. Biol. Chem.282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DPY30
14.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
15.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-599;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states."
Agarwal S.K. , Kester M.B. , Debelenko L.V. , Heppner C. , Emmert-Buck M.R. , Skarulis M.C. , Doppman J.L. , Kim Y.S. , Lubensky I.A. , Zhuang Z. , Green J.S. , Guru S.C. , Manickam P. , Olufemi S.E. , Liotta L.A. , Chandrasekharappa S.C. , Collins F.S. , Spiegel A.M. , more...
Hum. Mol. Genet.6:1169-1175(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1
18.

"Identification of the multiple endocrine neoplasia type 1 (MEN1) gene."
The European consortium on MEN1 , Lemmens I. , Van de Ven W.J.M. , Kas K. , Zhang C.X. , Giraud S. , Wautot V. , Buisson N. , De Witte K. , Salandre J. , Lenoir G. , Pugeat M. , Calender A. , Parente F. , Quincey D. , Gaudray P. , De Wit M.J. , Lips C.J.M. , more...
Hum. Mol. Genet.6:1177-1183(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 SER-188;VARIANT GLN-176
19.

"Somatic mutation of the MEN1 gene in parathyroid tumours."
Heppner C. , Kester M.B. , Agarwal S.K. , Debelenko L.V. , Emmert-Buck M.R. , Guru S.C. , Manickam P. , Olufemi S.-E. , Skarulis M.C. , Doppman J.L. , Alexander R.H. , Kim Y.S. , Saggar S.K. , Lubensky I.A. , Zhuang Z. , Liotta L.A. , Chandrasekharappa S.C. , Collins F.S. , more...
Nat. Genet.16:375-378(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARATHYROID ADENOMA LYS-26
20.

"Characterization of mutations in patients with multiple endocrine neoplasia type 1."
Bassett J.H.D. , Forbes S.A. , Pannett A.A.J. , Lloyd S.E. , Christie P.T. , Wooding C. , Harding B. , Besser G.M. , Edwards C.R. , Monson J.P. , Sampson J. , Wass J.A.H. , Wheeler M.H. , Thakker R.V.
Am. J. Hum. Genet.62:232-244(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 ASP-42; PRO-165; ASP-169; SER-188 AND GLU-289
21.

"Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders."
Giraud S. , Zhang C.X. , Serova-Sinilnikova O. , Wautot V. , Salandre J. , Buisson N. , Waterlot C. , Bauters C. , Porchet N. , Aubert J.-P. , Emy P. , Cadiot G. , Delemer B. , Chabre O. , Niccoli P. , Leprat F. , Duron F. , Emperauger B. , more...
Am. J. Hum. Genet.63:455-467(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1
22.

"A family with isolated hyperparathyroidism segregating a missense MEN1 mutation and showing loss of the wild-type alleles in the parathyroid tumors."
Teh B.T. , Esapa C.T. , Houlston R. , Grandell U. , Farnebo F. , Nordenskjoeld M. , Pearce C.J. , Carmichael D. , Larsson C. , Harris P.E.
Am. J. Hum. Genet.63:1544-1549(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FIHP LYS-260
23.

"Novel V184E MEN1 germline mutation in a Japanese kindred with familial hyperparathyroidism."
Fujimori M. , Shirahama S. , Sakurai A. , Hashizume K. , Hama Y. , Ito K. , Shingu K. , Kobayashi S. , Amano J. , Fukushima Y.
Am. J. Med. Genet.80:221-222(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FIHP GLU-189
24.

"MEN1 gene mutations in 12 MEN1 families and their associated tumors."
Bartsch D. , Kopp I. , Bergenfelz A. , Rieder H. , Muench K. , Jaeger K. , Deiss Y. , Schudy A. , Barth P. , Arnold R. , Rothmund M. , Simon B.
Eur. J. Endocrinol.139:416-420(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 LYS-26 AND PRO-173
25.

"Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families."
Agarwal S.K. , Debelenko L.V. , Kester M.B. , Guru S.C. , Manickam P. , Olufemi S.-E. , Skarulis M.C. , Heppner C. , Crabtree J.S. , Lubensky I.A. , Zhuang Z. , Kim Y.S. , Chandrasekharappa S.C. , Collins F.S. , Liotta L.A. , Spiegel A.M. , Burns A.L. , Emmert-Buck M.R. , more...
Hum. Mutat.12:75-82(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1
26.

"Five novel mutations in the familial multiple endocrine neoplasia type 1 (MEN1) gene."
Cote G.J. , Lee J.E. , Evans D.B. , Huang E. , Schultz P.N. , Dang G.T. , Qiu H. , Shetelbine S. , Sellin R.V. , Gagel R.F.
Hum. Mutat.12:219-219(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 ARG-432
27.

"Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese."
Tanaka C. , Yoshimoto K. , Yamada S. , Nishioka H. , Ii S. , Moritani M. , Yamaoka T. , Itakura M.
J. Clin. Endocrinol. Metab.83:960-965(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 LEU-325;VARIANT ALA-546
28.

"Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism."
Teh B.T. , Kytoelae S. , Farnebo F. , Bergman L. , Wong F.K. , Weber G. , Hayward N. , Larsson C. , Skogseid B. , Beckers A. , Phelan C. , Edwards M. , Epstein M. , Alford F. , Hurley D. , Grimmond S. , Silins G. , Walters M. , more...
J. Clin. Endocrinol. Metab.83:2621-2626(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 ASN-423;VARIANTS GLN-176 AND ALA-546
29.

"Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism."
Carling T. , Correa P. , Hessman O. , Hedberg J. , Skogseid B. , Lindberg D. , Rastad J. , Westin G. , Akerstrom G.
J. Clin. Endocrinol. Metab.83:2960-2963(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 ASP-139;VARIANT TRP-157
30.

"Menin mutations in MEN1 patients."
Mayr B. , Brabant G. , von zur Muehlen A.
J. Clin. Endocrinol. Metab.83:3004-3005(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 SER-428
31.

"Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas."
Boeni R. , Vortmeyer A.O. , Pack S. , Park W.-S. , Burg G. , Hofbauer G. , Darling T. , Liotta L. , Zhuang Z.
J. Invest. Dermatol.111:539-540(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 ILE-135 AND LYS-364
32.

"Novel MEN1 gene mutations in familial multiple endocrine neoplasia type 1."
Sakurai A. , Shirahama S. , Fujimori M. , Katai M. , Itakura Y. , Kobayashi S. , Amano J. , Fukushima Y. , Hashizume K.
J. Hum. Genet.43:199-201(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 LYS-119 DEL AND 171-GLN--LEU-173 DEL
33.

"Identification of five novel germline mutations of the MEN1 gene in Japanese multiple endocrine neoplasia type 1 (MEN1) families."
Sato M. , Matsubara S. , Miyauchi A. , Ohye H. , Imachi H. , Murao K. , Takahara J.
J. Med. Genet.35:915-919(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 GLY-45
34.

"Molecular pathology of multiple endocrine neoplasia type I: two novel germline mutations and updated classification of mutations affecting MEN1 gene."
Martin-Campos J.M. , Catasus L. , Chico A. , Mayoral C. , Lagarda E. , Gallart L. , Mato E. , Rodriguez-Espinosa J. , Matias-Guiu X. , De Leiva A. , Blanco-Vaca F.
Diagn. Mol. Pathol.8:195-204(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 ARG-139
35.

"A new mutation of the MEN1 gene in an Italian kindred with multiple endocrine neoplasia type 1."
Cetani F. , Pardi E. , Cianferotti L. , Vignali E. , Picone A. , Miccoli P. , Pinchera A. , Marcocci C.
Eur. J. Endocrinol.140:429-433(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 PRO-449
36.

"Germline MEN1 mutations in sixteen Japanese families with multiple endocrine neoplasia type 1 (MEN1)."
Hai N. , Aoki N. , Matsuda A. , Mori T. , Kosugi S.
Eur. J. Endocrinol.141:475-480(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 ARG-188; ARG-230; TYR-246 AND PRO-258;VARIANT ALA-546
37.

"MEN I gene mutations in sporadic adrenal adenomas."
Schulte K.-M. , Heinze M. , Mengel M. , Simon D. , Scheuring S. , Koehrer K. , Roeher H.-D.
Hum. Genet.105:603-610(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ADRENAL ADENOMA SER-557
38.

"Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases."
Poncin J. , Abs R. , Velkeniers B. , Bonduelle M. , Abramowicz M. , Legros J.-J. , Verloes A. , Meurisse M. , van Gaal L. , Verellen C. , Koulischer L. , Beckers A.
Hum. Mutat.13:54-60(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 TRP-39; TYR-177; ASP-184 AND PRO-269;VARIANT FIHP PRO-272;VARIANTS GLN-176 AND ALA-546
39.

"Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects."
Mutch M.G. , Dilley W.G. , Sanjurjo F. , Debenedetti M.K. , Doherty G.M. , Wells S.A. Jr. , Goodfellow P.J. , Lairmore T.C.
Hum. Mutat.13:175-185(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 ASP-161 AND ARG-246
40.

"Germline mutations in the MEN1 gene: creation of a new splice acceptor site and insertion of 7 intron nucleotides into the mRNA."
Engelbach M. , Forst T. , Hankeln T. , Tratzky M. , Heerdt S. , Pfuetzner A. , Kann P. , Kunt T. , Schneider S. , Schmidt E.R. , Beyer J.
Int. J. Mol. Med.4:483-485(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 PHE-160
41.

"Identification of MEN1 gene mutations in families with MEN 1 and related disorders."
Bergman L. , Teh B.T. , Cardinal J. , Palmer J. , Walters M. , Shepherd J. , Cameron D. , Hayward N.
Br. J. Cancer83:1009-1014(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 LEU-234; ASP-358; SER-378 AND PRO-420
42.

"Screening of the MEN1 gene and discovery of germ-line and somatic mutations in apparently sporadic parathyroid tumors."
Uchino S. , Noguchi S. , Sato M. , Yamashita H. , Yamashita H. , Watanabe S. , Murakami T. , Toda M. , Ohshima A. , Futata T. , Mizukoshi T. , Koike E. , Takatsu K. , Terao K. , Wakiya S. , Nagatomo M. , Adachi M.
Cancer Res.60:5553-5557(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARATHYROID TUMOR ASP-161; ARG-188; TRP-258; ALA-279 AND PRO-289
43.

"Criteria for mutation analysis in MEN 1-suspected patients: MEN 1 case-finding."
Roijers J.F.M. , de Wit M.J. , van der Luijt R.B. , Ploos van Amstel H.K. , Hoeppener J.W.M. , Lips C.J.M.
Eur. J. Clin. Invest.30:487-492(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 TRP-39; LYS-119 DEL; GLN-184; PRO-228; ARG-322; PRO-342; ASN-353; VAL-390 AND SER-549
44.

"MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1."
Morelli A. , Falchetti A. , Martineti V. , Becherini L. , Mark M. , Friedman E. , Brandi M.L.
Eur. J. Endocrinol.142:131-137(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 LYS-45; MET-220 AND ARG-349
45.

"A novel mutation of the MEN1 gene in a Japanese kindred with familial isolated primary hyperparathyroidism."
Honda M. , Tsukada T. , Tanaka H. , Maruyama K. , Yamaguchi K. , Obara T. , Yamaji T. , Ishibashi M.
Eur. J. Endocrinol.142:138-143(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FIHP ASP-310
46.

"A novel mutation E179K of the MEN1 gene predisposes for multiple endocrine neoplasia-type 1 (MEN1)."
Weinhaeusel A. , Vierhapper H. , Schlegl R. , Wagner T. , Muhr D. , Scheuba C. , Niederle B. , Haas O.A.
Hum. Mutat.16:533-533(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 LYS-184
47.

"Familial isolated hyperparathyroidism as a variant of multiple endocrine neoplasia type 1 in a large Danish pedigree."
Kassem M. , Kruse T.A. , Wong F.K. , Larsson C. , Teh B.T.
J. Clin. Endocrinol. Metab.85:165-167(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FIHP PRO-265
48.

"Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1."
Stratakis C.A. , Schussheim D.H. , Freedman S.M. , Keil M.F. , Pack S.D. , Agarwal S.K. , Skarulis M.C. , Weil R.J. , Lubensky I.A. , Zhuang Z. , Oldfield E.H. , Marx S.J.
J. Clin. Endocrinol. Metab.85:4776-4780(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 ASP-139
49.

"Identification of three novel menin mutations (c.741delGTCA, c.1348T>C, c.1785delA) in unrelated Italian families affected with multiple endocrine neoplasia type 1: additional information for mutational screening."
Asteria C. , Faglia G. , Roncoroni R. , Borretta G. , Ribotto P. , Beck-Peccoz P.
Hum. Mutat.17:237-237(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 PRO-419
50.

"Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein."
Wautot V. , Vercherat C. , Lespinasse J. , Chambe B. , Lenoir G.M. , Zhang C.X. , Porchet N. , Cordier M. , Beroud C. , Calender A.
Hum. Mutat.20:35-47(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 TRP-39; ASP-42; LEU-98; PRO-165; THR-165; PHE-167; ASP-169; ARG-170; TYR-177; PRO-228; PHE-245; ARG-286; PRO-316; PRO-319; TYR-322; ARG-322; ASP-342; ARG-346; HIS-362; ASP-373; MET-377; ASN-423; CYS-532; ASN-560 AND ARG-560
51.

"A novel six-nucleotide insertion in exon 4 of the MEN1 gene, 878insCTGCAG, in three patients with familial insulinoma and primary hyperparathyroidism."
Okamoto H. , Tamada A. , Hai N. , Doi M. , Uchimura I. , Hirata Y. , Kosugi S.
Jpn. J. Clin. Oncol.32:368-370(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 LEU-GLN-266 INS
52.

"Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1."
Turner J.J.O. , Leotlela P.D. , Pannett A.A.J. , Forbes S.A. , Bassett J.H.D. , Harding B. , Christie P.T. , Bowen-Jones D. , Ellard S. , Hattersley A. , Jackson C.E. , Pope R. , Quarrell O.W. , Trembath R. , Thakker R.V.
J. Clin. Endocrinol. Metab.87:2688-2693(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 LYS-119 DEL; ILE-159; GLU-368 DEL AND ASN-423
53.

"Genetic screening for MEN1 mutations in families presenting with familial primary hyperparathyroidism."
Perrier N.D. , Villablanca A. , Larsson C. , Wong M. , Ituarte P. , Teh B.T. , Clark O.H.
World J. Surg.26:907-913(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FIHP HIS-282
54.

"Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism."
Pannett A.A.J. , Kennedy A.M. , Turner J.J.O. , Forbes S.A. , Cavaco B.M. , Bassett J.H.D. , Cianferotti L. , Harding B. , Shine B. , Flinter F. , Maidment C.G.H. , Trembath R. , Thakker R.V.
Clin. Endocrinol. (Oxf.)58:639-646(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 AND FIHP VAL-158 AND PRO-416
55.

"Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders."
Park J.-H. , Kim I.-J. , Kang H.C. , Lee S.-H. , Shin Y. , Kim K.-H. , Lim S.-B. , Kang S.-B. , Lee K.U. , Kim S.Y. , Lee M.-S. , Lee M.-K. , Park J.-H. , Moon S.-D. , Park J.-G.
Clin. Genet.64:48-53(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 PRO-330
56.

"Efficient mutation detection in MEN1 gene using a combination of single-strand conformation polymorphism (MDGA) and heteroduplex analysis."
Groupe d'etude des neoplasies endocriniennes multiples , Crepin M. , Escande F. , Pigny P. , Buisine M.-P. , Calender A. , Porchet N. , Odou M.-F.
Electrophoresis24:26-33(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 ARG-170; PRO-228; PHE-246; ARG-286; PRO-316; TYR-322; ASN-423 AND SER-545
57.

"A novel missense mutation of the MEN1 gene in a multiple endocrine neoplasia type 1 patient associated with carcinoid syndrome."
Ukita C. , Yamaguchi M. , Tanaka T. , Shigeta H. , Nishikawa M.
Intern. Med.42:1112-1116(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MEN1 PRO-347
58.

"Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients."
Cebrian A. , Ruiz-Llorente S. , Cascon A. , Pollan M. , Diez J.J. , Pico A. , Telleria D. , Benitez J. , Robledo M.
J. Med. Genet.40:E72-E72(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 LYS-45 AND PRO-139;VARIANTS GLN-176 AND ALA-546
59.

"Unusual presentation of multiple endocrine neoplasia type 1 in a young woman with a novel mutation of the MEN1 gene."
Balogh K. , Patocs A. , Majnik J. , Varga F. , Illyes G. , Hunyady L. , Racz K.
J. Hum. Genet.49:380-386(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLN-176
60.

"Novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1."
Jap T.-S. , Chiu C.-Y. , Won J.G.-S. , Wu Y.-C. , Chen H.-S.
Clin. Endocrinol. (Oxf.)62:336-342(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 GLU-110 AND HIS-423
61.

"Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory."
Klein R.D. , Salih S. , Bessoni J. , Bale A.E.
Genet. Med.7:131-138(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEN1 VAL-144; ASP-161; ASP-184; LYS-184; ARG-186; MET-220; ARG-264; ARG-325; TRP-360; TYR-426; CYS-441 AND ARG-441
62.

"Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas."
Haven C.J. , van Puijenbroek M. , Tan M.H. , Teh B.T. , Fleuren G.J. , van Wezel T. , Morreau H.
Clin. Endocrinol. (Oxf.)67:370-376(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PHE-220;ASSOCIATION WITH PARATHYROID CARCINOMA
63.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-546;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
64.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-546;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.

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