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Index > Protein center > Mertk(Gene name) > Mouse
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  • Mertk (Gene name),
  • Tyrosine-protein kinase Mer (Protein name ),  MERTK_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Mertk(Mer);
    Protein name:
    Tyrosine-protein kinase Mer;
    Alternative:
    Receptor tyrosine kinase MerTK;Proto-oncogene c-Mer;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation.
    Function:
    N/A
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    994
    Sequence:
    50:
    MVLAPLLLGL | LLLPALWSGG | TAEKWEETEL | DQLFSGPLPG | RLPVNHRPFS | 
    100:
    APHSSRDQLP | PPQTGRSHPA | HTAAPQVTST | ASKLLPPVAF | NHTIGHIVLS | 
    150:
    EHKNVKFNCS | INIPNTYQET | AGISWWKDGK | ELLGAHHSIT | QFYPDEEGVS | 
    200:
    IIALFSIASV | QRSDNGSYFC | KMKVNNREIV | SDPIYVEVQG | LPYFIKQPES | 
    250:
    VNVTRNTAFN | LTCQAVGPPE | PVNIFWVQNS | SRVNEKPERS | PSVLTVPGLT | 
    300:
    ETAVFSCEAH | NDKGLTVSKG | VHINIKVIPS | PPTEVHILNS | TAHSILVSWV | 
    350:
    PGFDGYSPLQ | NCSIQVKEAD | RLSNGSVMVF | NTSASPHLYE | IQQLQALANY | 
    400:
    SIAVSCRNEI | GWSAVSPWIL | ASTTEGAPSV | APLNITVFLN | ESNNILDIRW | 
    450:
    TKPPIKRQDG | ELVGYRISHV | WESAGTYKEL | SEEVSQNGSW | AQIPVQIHNA | 
    500:
    TCTVRIAAIT | KGGIGPFSEP | VNIIIPEHSK | VDYAPSSTPA | PGNTDSMFII | 
    550:
    LGCFCGFILI | GLILCISLAL | RRRVQETKFG | GAFSEEDSQL | VVNYRAKKSF | 
    600:
    CRRAIELTLQ | SLGVSEELQN | KLEDVVIDRN | LLVLGKVLGE | GEFGSVMEGN | 
    650:
    LKQEDGTSQK | VAVKTMKLDN | FSQREIEEFL | SEAACMKDFN | HPNVIRLLGV | 
    700:
    CIELSSQGIP | KPMVILPFMK | YGDLHTFLLY | SRLNTGPKYI | HLQTLLKFMM | 
    750:
    DIAQGMEYLS | NRNFLHRDLA | ARNCMLRDDM | TVCVADFGLS | KKIYSGDYYR | 
    800:
    QGRIAKMPVK | WIAIESLADR | VYTSKSDVWA | FGVTMWEITT | RGMTPYPGVQ | 
    850:
    NHEMYDYLLH | GHRLKQPEDC | LDELYDIMYS | CWSADPLDRP | TFSVLRLQLE | 
    900:
    KLSESLPDAQ | DKESIIYINT | QLLESCEGIA | NGPSLTGLDM | NIDPDSIIAS | 
    950:
    CTPGAAVSVV | TAEVHENNLR | EERYILNGGN | EEWEDVSSTP | FAAVTPEKDG | 
    994:
    VLPEDRLTKN | GVSWSHHSTL | PLGSPSPDEL | LFVDDSLEDS | EVLM
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Tyrosine-protein kinase Mer
    Cat.:
    E1419h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Tyrosine-protein kinase Mer
    Cat.:
    E1419r
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Tyrosine-protein kinase Mer
    Cat.:
    E1419m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tyrosine-protein kinase Mer
    Cat.:
    U1419r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tyrosine-protein kinase Mer
    Cat.:
    U1419h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tyrosine-protein kinase Mer
    Cat.:
    U1419m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Tyrosine-protein kinase Mer
    Cat.:
    P1419Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tyrosine-protein kinase Mer
    Cat.:
    P1419Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tyrosine-protein kinase Mer
    Cat.:
    P1419Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Tyrosine-protein kinase Mer
    Monoclonal Antibody for Mouse Tyrosine-protein kinase Mer
    Monoclonal Antibody for Mouse Tyrosine-protein kinase Mer
    Protein for Mouse Tyrosine-protein kinase Mer
    Protein for Mouse Tyrosine-protein kinase Mer
    Protein for Mouse Tyrosine-protein kinase Mer

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and developmental expression analysis of the murine c-mer tyrosine kinase."
      Graham D.K. , Bowman G.W. , Dawson T.L. , Stanford W.L. , Earp H.S. , Snodgrass H.R.
      Oncogene10:2349-2359(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6.
      tissue: Spleen.
    2. 2.
      "A cDNA encoding part of a novel putative receptor tyrosine kinase."
      Dowds C.A. , Burks D.J. , Saling P.M.
      Submitted (1996-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 472-994
      strain: CD-1.
      tissue: Testis.
    3. 3.
      "Tyro-3 family receptors are essential regulators of mammalian spermatogenesis."
      Lu Q. , Gore M. , Zhang Q. , Camenisch T. , Boast S. , Casagranda F. , Lai C. , Skinner M.K. , Klein R. , Matsushima G.K. , Earp H.S. , Goff S.P. , Lemke G.
      Nature398:723-728(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    4. 4.
      "Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB."
      Georgescu M.M. , Kirsch K.H. , Shishido T. , Zong C. , Hanafusa H.
      Mol. Cell. Biol.19:1171-1181(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2;MUTAGENESIS OF TYR-867
    5. 5.
      "The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity."
      Behrens E.M. , Gadue P. , Gong S.Y. , Garrett S. , Stein P.L. , Cohen P.L.
      Eur. J. Immunol.33:2160-2167(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      "The receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophages."
      Todt J.C. , Hu B. , Curtis J.L.
      J. Leukoc. Biol.75:705-713(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLCG2
    7. 7.
      "A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells."
      Wu Y. , Singh S. , Georgescu M.M. , Birge R.B.
      J. Cell Sci.118:539-553(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAK/PTK2
    8. 8.
      "Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation."
      Tibrewal N. , Wu Y. , D'mello V. , Akakura R. , George T.C. , Varnum B. , Birge R.B.
      J. Biol. Chem.283:3618-3627(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-867
    9. 9.
      "Mertk drives myosin II redistribution during retinal pigment epithelial phagocytosis."
      Strick D.J. , Feng W. , Vollrath D.
      Invest. Ophthalmol. Vis. Sci.50:2427-2435(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis."
      Caberoy N.B. , Zhou Y. , Li W.
      EMBO J.29:3898-3910(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TUB AND TULP1
    11. 11.
      "Sertoli cell-initiated testicular innate immune response through toll-like receptor-3 activation is negatively regulated by Tyro3, Axl, and mer receptors."
      Sun B. , Qi N. , Shang T. , Wu H. , Deng T. , Han D.
      Endocrinology151:2886-2897(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IMMUNE RESPONSE INHIBITION
    12. 12.
      "Galectin-3 is a new MerTK-specific eat-me signal."
      Caberoy N.B. , Alvarado G. , Bigcas J.L. , Li W.
      J. Cell. Physiol.227:401-407(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LGALS3
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