Mesp2 ELISA Kit for Mouse(Mus musculus) | EIAab.comMesp2 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Mesp2 (Gene name),

Mesoderm posterior protein 2 (Protein name ), MESP2_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

Mesp2;

Protein name:

Mesoderm posterior protein 2;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

N/A

Function:

Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes. Controls also the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1. Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

370

Sequence:

50:

MAQSSPPQSL | QGLVPLGLLP | GLGLGSAIGL | HVSGLVLRFV | RFLPFYATRR |

100:

PSQPAGPARS | TRTTQATAPR | RTRPAPAGGQ | RQSASEREKL | RMRTLARALQ |

150:

ELRRFLPPSV | APAGQSLTKI | ETLRLAIRYI | GHLSALLGLS | EDSLRRRRRR |

200:

SADAAFSHRC | PQCPDGGSPS | QAQMLGPSLG | SAMSSGVSWG | CPPACPGPLI |

250:

SPENLGNRIS | NVDPRVTPPY | CPQIQSPLHQ | SLERAADSSP | WAPPQACPGM |

300:

QMSPEPRNKT | GHWTQSTEPA | ELTKVYQSLS | VSPEPRLSLG | SPLLLPRPSC |

350:

QRLQPQPQPQ | PQWGCWGHDA | EVLSTSEDQG | SSPALQLPVA | SPTPSSGLQL |

370:

SGCPELWQED | LEGPPLNIFY |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

SMR:

String:

UniGene:

Pfam:

Uniprot:

FOR

ELISA Kit for Mouse Mesoderm posterior protein 2

ELISA Kit for Mouse Mesoderm posterior protein 2

CLIA Kit for Mouse Mesoderm posterior protein 2

CLIA Kit for Mouse Mesoderm posterior protein 2

Polyclonal Antibody for Mouse Mesoderm posterior protein 2

Polyclonal Antibody for Mouse Mesoderm posterior protein 2

Monoclonal Antibody for Mouse Mesoderm posterior protein 2

Monoclonal Antibody for Mouse Mesoderm posterior protein 2

Protein for Mouse Mesoderm posterior protein 2

Protein for Mouse Mesoderm posterior protein 2

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation."
Saga Y. , Hata N. , Koseki H. , Taketo M.M.
Genes Dev.11:1827-1839(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;DEVELOPMENTAL STAGE;INDUCTION;DISRUPTION PHENOTYPE
strain: ICR.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 107-370
strain: C57BL/6J.
tissue: Liver.
3.

"Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse."
del Barco Barrantes I. , Elia A.J. , Wuensch K. , De Angelis M.H. , Mak T.W. , Rossant J. , Conlon R.A. , Gossler A. , de la Pompa J.L.
Curr. Biol.9:470-480(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
4.

"MesP1 and MesP2 are essential for the development of cardiac mesoderm."
Kitajima S. , Takagi A. , Inoue T. , Saga Y.
Development127:3215-3226(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DEVELOPMENT OF CARDIAC MESODERM;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
5.

"Mesp2 initiates somite segmentation through the Notch signalling pathway."
Takahashi Y. , Koizumi K. , Takagi A. , Kitajima S. , Inoue T. , Koseki H. , Saga Y.
Nat. Genet.25:390-396(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
6.

"The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis."
Kume T. , Jiang H. , Topczewska J.M. , Hogan B.L.
Genes Dev.15:2470-2482(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
7.

"Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites."
Takahashi Y. , Inoue T. , Gossler A. , Saga Y.
Development130:4259-4268(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"The protocadherin papc is involved in the organization of the epithelium along the segmental border during mouse somitogenesis."
Rhee J. , Takahashi Y. , Saga Y. , Wilson-Rawls J. , Rawls A.
Dev. Biol.254:248-261(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites."
Takahashi Y. , Kitajima S. , Inoue T. , Kanno J. , Saga Y.
Development132:787-796(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity."
Morimoto M. , Takahashi Y. , Endo M. , Saga Y.
Nature435:354-359(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
11.

"Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2."
Nakajima Y. , Morimoto M. , Takahashi Y. , Koseki H. , Saga Y.
Development133:2517-2525(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING
12.

"Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis."
Morimoto M. , Kiso M. , Sasaki N. , Saga Y.
Dev. Biol.300:687-698(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DEGRADATION;PHOSPHORYLATION;MUTAGENESIS OF 70-ARG--ARG-73 AND 145-ARG--ARG-150
13.

"Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression."
Yasuhiko Y. , Haraguchi S. , Kitajima S. , Takahashi Y. , Kanno J. , Saga Y.
Proc. Natl. Acad. Sci. U.S.A.103:3651-3656(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY TBX6 AND NOTCH SIGNALING
14.

"The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite."
Morimoto M. , Sasaki N. , Oginuma M. , Kiso M. , Igarashi K. , Aizaki K. , Kanno J. , Saga Y.
Development134:1561-1569(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;INDUCTION BY RIPPLY2
15.

"Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation."
Takahashi Y. , Yasuhiko Y. , Kitajima S. , Kanno J. , Saga Y.
Dev. Biol.304:593-603(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
16.

"Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation."
Takahashi Y. , Takagi A. , Hiraoka S. , Koseki H. , Kanno J. , Rawls A. , Saga Y.
Dev. Dyn.236:1484-1494(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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