Gene name:
Mga(Kiaa4252);
Protein name:
MAX gene-associated protein;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Interacts with MAX. Requires heterodimerization with MAX for E-box binding.
Function:
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MEEKQQIILA | NQDGGTVTGG | APTFFVILKQ | PGNGKTDQGI | LVTNRDARAL |
100:
LSRESSPGKS | KEKICLPADC | TVGKITVTLD | NNSMWNEFHN | RSTEMILTKQ |
150:
GRRMFPYCRY | WITGLDSNLK | YILVMDISPV | DSHRYKWNGR | WWEPSGKAEP |
200:
HILGRVFIHP | ESPSTGHYWM | HQPVSFYKLK | LTNNTLDQEG | HIILHSMHRY |
250:
LPRLHLVPAE | KATEVIQLNG | PGVHTFTFPQ | TEFFAVTAYQ | NIQITQLKID |
300:
YNPFAKGFRD | DGLSSKPQRE | GKQRNSSDQE | GNSVSSSPAH | RVRLTEGEGS |
350:
EIHSGDFDPV | LRGHEASSLS | LEKAPHNVKQ | DFLGFMNTDS | THEVPQLKHE |
400:
ISESRIVNSF | EDDSQISSPS | NPNGNFNVVI | KEEPLDDYDY | ELGECPEGIT |
450:
VKQEETDEET | DVYSNSDDDP | ILEKQLKRHN | KVDNLEADHP | SYKWLPNSPG |
500:
VAKAKMFKLD | AGKMPVVYLE | PCAVTKSTVK | ISELPDNMLS | TSRKDKSMLA |
550:
ELEYLPAYIE | NSDGTDFCLS | KDSENSLRKH | SPDLRIVQKY | TLLKEPNWKY |
600:
PDILDNSSTE | RIHDSSKGST | AESFSGKEDL | GKKRTTMLKM | AIPSKTVTAS |
650:
HSASPNTPGK | RGRPRKLRLS | KAGRPPKNTG | KSLTAAKNIP | VGPGSTFPDV |
700:
KPDLEDVDGV | LFVSFESKEA | LDIHAVDGTT | EEPSSLQTTT | TNDSGCRTRI |
750:
SQLEKELIED | LKSLRHKQVI | HPALQEVGLK | LNSVDPTVSI | DLKYLGVQLP |
800:
LAPATSFPLW | NVTGTNPASP | DAGFPFVSRT | GKTNDFTKIK | GWRGKFQNAS |
850:
ASRNEGGNSE | ASLKNRSAFC | SDKLDEYLEN | EGKLMETNIG | FSSNAPTSPV |
900:
VYQLPTKSTS | YVRTLDSVLK | KQSTISPSTS | HSVKPQSVTT | ASRKTKAQNK |
950:
QTTLSGRTKS | SYKSILPYPV | SPKQKNSHVS | QGDKITKNSL | SSTSDNQVTN |
1000:
LVVPSVDENA | FPKQISLRQA | QQQHLQQQGT | RPPGLSKSQV | KLMDLEDCAL |
1050:
WEGKPRTYIT | EERADVSLTT | LLTAQASLKT | KPIHTIIRKR | APPCNNDFCR |
1100:
LGCVCSSLAL | EKRQPAHCRR | PDCMFGCTCL | KRKVVLVKGG | SKTKHFHKKA |
1150:
ANRDPLFYDT | LGEEGREGGG | VREDEEQLKE | KKKRKKLEYT | VCEAEPEQPV |
1200:
RHYPLWVKVE | GEVDPEPVYI | PTPSVIEPIK | PLVLPQPDLS | STTKGKLTPG |
1250:
IKPARTYTPK | PNPVIREEDK | DPVYLYFESM | MTCARVRVYE | RKKEEQRQLS |
1300:
PPLSPSSSFQ | QQSSCYSSPE | NRVTKELDSE | QTLKQLICDL | EDDSDKSQEK |
1350:
SWKSSCNEGE | SSSTSYVHQR | SPGGPTKLIE | IISDCNWEED | RNKILSILSQ |
1400:
HINSNMPQSL | KVGSFIIELA | SQRKCRGEKT | PPVYSSRVKI | SMPSSQDQDD |
1450:
MAEKSGSETP | DGPLSPGKMD | DISPVQTDAL | DSVRERLHGG | KGLPFYAGLS |
1500:
PSGKLVAYKR | KPSSTTSGLI | QVASNAKVAA | SRKPRTLLPS | TSNSKMASSG |
1550:
PATNRSGKNL | KAFVPAKRPI | AARPSPGGVF | TQFVMSKVGA | LQQKIPGVRT |
1600:
PQPLTGPQKF | SIRPSPVMVV | TPVVSSEQVQ | VCSTVAAAVT | TSPQVFLENV |
1650:
TAVPSLTANS | DMGAKEATYS | SSASTAGVVE | ISETNNTTLV | TSTQSTATVN |
1700:
LTKTTGITTS | PVASVSFAKP | LVASPTITLP | VASTASTSIV | MVTTAASSSV |
1750:
VTTPTSSLSS | VPIILSGING | SPPVSQRPEN | APQIPVTTPQ | ISSNNVKRTG |
1800:
PRLLHPNGQI | VQLLPLHQIR | GSNAQPSLQP | VVFRNPGSMV | GIRLPAPCKS |
1850:
SETPSSSASS | SAFSVMSPVI | QAVGSSPTVN | VISQAPSLLS | SGSSFVSQAG |
1900:
TLTLRISPPE | TQNLASKTGS | ESKITPSTGG | QPVGTASLIP | LQSGSFALLQ |
1950:
LPGQKPIPSS | VLQHVASLQI | KKESQSTDQK | DETNSIKREE | ETKKALPSKD |
2000:
KALDSEANIM | KQNSGIIASE | NTSNNSLDDG | GDLLDEETLR | EDARPYEYSY |
2050:
STGSHTDEDK | DGDEDSGNKN | QNSPKEKQTV | PEVRAGSKNI | DIMALQSIRS |
2100:
IRPQKCVKVK | VEPQEGSDNP | ENPDDFLVLS | KDSKFELSGN | QVKEQQSNSQ |
2150:
AEAKKDCEDS | LGKDSLRERW | RKHLKGPLTQ | KYIGISQNFN | KEANVQFFTE |
2200:
MKPCQENSEQ | DISELLGKSG | TIESGGVLKT | EDGSWSGISS | SAAFSIIPRR |
2250:
ATKGRRGSRH | FQGHLLLPRE | QMKPKQQTKD | GRSSAADFTV | LDLEDEDEED |
2300:
EKTDDSLDEI | VDVVSGYQSE | EVDVEKNNYV | DYLEDDEQVD | VETIEELSEE |
2350:
INFPYKKTTA | THTQSFKQQC | HSHISADEKA | SEKSRKVSLI | SSKLKDDCWG |
2400:
DKPHKETEAF | AYYRRTHTAN | ERRRRGEMRD | LFEKLKITLG | LLHSSKVSKS |
2450:
LILNRAFSEI | QGLTDQADKL | IGQKNLLSRK | RSILIRKVSS | LSGKTEEVVL |
2500:
KKLEYIYAKQ | QALEAQKRKK | KLGSDEFCVS | PRIGTQLEGS | SASSVDLGQM |
2550:
LMNNRRGKPL | ILSRKRDQAT | ENASPSDTPH | SSANLVMTPQ | GQLLTLKGPL |
2600:
FSGPVVAVSP | ALLEGGLKPQ | VASSTMSQSE | NDDLFMMPRI | VNVTSLAAEE |
2650:
DLGGMSGNKY | RHEVPDGKPL | DHLRDIAGSE | ASSLKDTERI | SSRGNHRDSR |
2700:
KALGPTQVLL | ANKDSGFPHV | ADVSTMQAAQ | EFIPKNMSGD | VRGHRYKWKE |
2750:
CELRGERLKS | KESQFHKLKM | KDLKDSSIEM | ELRKVASAIE | EAALHPSELL |
2800:
TNMEDEDDTD | ETLTSLLNEI | AFLNQQLNDD | SGLAELSGSM | DTEFSGDAQR |
2850:
AFISKLAPGN | RSAFQVGHLG | AGVKELPDVQ | EESESISPLL | LHLEDDDFSE |
2900:
NEKQLGDTAS | EPDVLKIVID | PEIKDSLVSH | RKSSDGGQST | SGLPAEPESV |
2950:
SSPPILHMKT | GPENSNTDTL | WRPMPKLAPL | GLKVANPPSD | ADGQSLKVMP |
3000:
ALAPIAAKVG | SIGHKMNLAG | IDQEGRGSKV | MPTLAPVVPK | LGNSGAPSSS |

Vaild Sequence:
Related Databases
Uniprot: