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Index > Protein center > Mga(Gene name) > Mouse
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  • Mga (Gene name),
  • MAX gene-associated protein (Protein name ),  MGAP_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mga(Kiaa4252);
    Protein name:
    MAX gene-associated protein;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Interacts with MAX. Requires heterodimerization with MAX for E-box binding.
    Function:
    Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    3003
    Sequence:
    50:
    MEEKQQIILA | NQDGGTVTGG | APTFFVILKQ | PGNGKTDQGI | LVTNRDARAL | 
    100:
    LSRESSPGKS | KEKICLPADC | TVGKITVTLD | NNSMWNEFHN | RSTEMILTKQ | 
    150:
    GRRMFPYCRY | WITGLDSNLK | YILVMDISPV | DSHRYKWNGR | WWEPSGKAEP | 
    200:
    HILGRVFIHP | ESPSTGHYWM | HQPVSFYKLK | LTNNTLDQEG | HIILHSMHRY | 
    250:
    LPRLHLVPAE | KATEVIQLNG | PGVHTFTFPQ | TEFFAVTAYQ | NIQITQLKID | 
    300:
    YNPFAKGFRD | DGLSSKPQRE | GKQRNSSDQE | GNSVSSSPAH | RVRLTEGEGS | 
    350:
    EIHSGDFDPV | LRGHEASSLS | LEKAPHNVKQ | DFLGFMNTDS | THEVPQLKHE | 
    400:
    ISESRIVNSF | EDDSQISSPS | NPNGNFNVVI | KEEPLDDYDY | ELGECPEGIT | 
    450:
    VKQEETDEET | DVYSNSDDDP | ILEKQLKRHN | KVDNLEADHP | SYKWLPNSPG | 
    500:
    VAKAKMFKLD | AGKMPVVYLE | PCAVTKSTVK | ISELPDNMLS | TSRKDKSMLA | 
    550:
    ELEYLPAYIE | NSDGTDFCLS | KDSENSLRKH | SPDLRIVQKY | TLLKEPNWKY | 
    600:
    PDILDNSSTE | RIHDSSKGST | AESFSGKEDL | GKKRTTMLKM | AIPSKTVTAS | 
    650:
    HSASPNTPGK | RGRPRKLRLS | KAGRPPKNTG | KSLTAAKNIP | VGPGSTFPDV | 
    700:
    KPDLEDVDGV | LFVSFESKEA | LDIHAVDGTT | EEPSSLQTTT | TNDSGCRTRI | 
    750:
    SQLEKELIED | LKSLRHKQVI | HPALQEVGLK | LNSVDPTVSI | DLKYLGVQLP | 
    800:
    LAPATSFPLW | NVTGTNPASP | DAGFPFVSRT | GKTNDFTKIK | GWRGKFQNAS | 
    850:
    ASRNEGGNSE | ASLKNRSAFC | SDKLDEYLEN | EGKLMETNIG | FSSNAPTSPV | 
    900:
    VYQLPTKSTS | YVRTLDSVLK | KQSTISPSTS | HSVKPQSVTT | ASRKTKAQNK | 
    950:
    QTTLSGRTKS | SYKSILPYPV | SPKQKNSHVS | QGDKITKNSL | SSTSDNQVTN | 
    1000:
    LVVPSVDENA | FPKQISLRQA | QQQHLQQQGT | RPPGLSKSQV | KLMDLEDCAL | 
    1050:
    WEGKPRTYIT | EERADVSLTT | LLTAQASLKT | KPIHTIIRKR | APPCNNDFCR | 
    1100:
    LGCVCSSLAL | EKRQPAHCRR | PDCMFGCTCL | KRKVVLVKGG | SKTKHFHKKA | 
    1150:
    ANRDPLFYDT | LGEEGREGGG | VREDEEQLKE | KKKRKKLEYT | VCEAEPEQPV | 
    1200:
    RHYPLWVKVE | GEVDPEPVYI | PTPSVIEPIK | PLVLPQPDLS | STTKGKLTPG | 
    1250:
    IKPARTYTPK | PNPVIREEDK | DPVYLYFESM | MTCARVRVYE | RKKEEQRQLS | 
    1300:
    PPLSPSSSFQ | QQSSCYSSPE | NRVTKELDSE | QTLKQLICDL | EDDSDKSQEK | 
    1350:
    SWKSSCNEGE | SSSTSYVHQR | SPGGPTKLIE | IISDCNWEED | RNKILSILSQ | 
    1400:
    HINSNMPQSL | KVGSFIIELA | SQRKCRGEKT | PPVYSSRVKI | SMPSSQDQDD | 
    1450:
    MAEKSGSETP | DGPLSPGKMD | DISPVQTDAL | DSVRERLHGG | KGLPFYAGLS | 
    1500:
    PSGKLVAYKR | KPSSTTSGLI | QVASNAKVAA | SRKPRTLLPS | TSNSKMASSG | 
    1550:
    PATNRSGKNL | KAFVPAKRPI | AARPSPGGVF | TQFVMSKVGA | LQQKIPGVRT | 
    1600:
    PQPLTGPQKF | SIRPSPVMVV | TPVVSSEQVQ | VCSTVAAAVT | TSPQVFLENV | 
    1650:
    TAVPSLTANS | DMGAKEATYS | SSASTAGVVE | ISETNNTTLV | TSTQSTATVN | 
    1700:
    LTKTTGITTS | PVASVSFAKP | LVASPTITLP | VASTASTSIV | MVTTAASSSV | 
    1750:
    VTTPTSSLSS | VPIILSGING | SPPVSQRPEN | APQIPVTTPQ | ISSNNVKRTG | 
    1800:
    PRLLHPNGQI | VQLLPLHQIR | GSNAQPSLQP | VVFRNPGSMV | GIRLPAPCKS | 
    1850:
    SETPSSSASS | SAFSVMSPVI | QAVGSSPTVN | VISQAPSLLS | SGSSFVSQAG | 
    1900:
    TLTLRISPPE | TQNLASKTGS | ESKITPSTGG | QPVGTASLIP | LQSGSFALLQ | 
    1950:
    LPGQKPIPSS | VLQHVASLQI | KKESQSTDQK | DETNSIKREE | ETKKALPSKD | 
    2000:
    KALDSEANIM | KQNSGIIASE | NTSNNSLDDG | GDLLDEETLR | EDARPYEYSY | 
    2050:
    STGSHTDEDK | DGDEDSGNKN | QNSPKEKQTV | PEVRAGSKNI | DIMALQSIRS | 
    2100:
    IRPQKCVKVK | VEPQEGSDNP | ENPDDFLVLS | KDSKFELSGN | QVKEQQSNSQ | 
    2150:
    AEAKKDCEDS | LGKDSLRERW | RKHLKGPLTQ | KYIGISQNFN | KEANVQFFTE | 
    2200:
    MKPCQENSEQ | DISELLGKSG | TIESGGVLKT | EDGSWSGISS | SAAFSIIPRR | 
    2250:
    ATKGRRGSRH | FQGHLLLPRE | QMKPKQQTKD | GRSSAADFTV | LDLEDEDEED | 
    2300:
    EKTDDSLDEI | VDVVSGYQSE | EVDVEKNNYV | DYLEDDEQVD | VETIEELSEE | 
    2350:
    INFPYKKTTA | THTQSFKQQC | HSHISADEKA | SEKSRKVSLI | SSKLKDDCWG | 
    2400:
    DKPHKETEAF | AYYRRTHTAN | ERRRRGEMRD | LFEKLKITLG | LLHSSKVSKS | 
    2450:
    LILNRAFSEI | QGLTDQADKL | IGQKNLLSRK | RSILIRKVSS | LSGKTEEVVL | 
    2500:
    KKLEYIYAKQ | QALEAQKRKK | KLGSDEFCVS | PRIGTQLEGS | SASSVDLGQM | 
    2550:
    LMNNRRGKPL | ILSRKRDQAT | ENASPSDTPH | SSANLVMTPQ | GQLLTLKGPL | 
    2600:
    FSGPVVAVSP | ALLEGGLKPQ | VASSTMSQSE | NDDLFMMPRI | VNVTSLAAEE | 
    2650:
    DLGGMSGNKY | RHEVPDGKPL | DHLRDIAGSE | ASSLKDTERI | SSRGNHRDSR | 
    2700:
    KALGPTQVLL | ANKDSGFPHV | ADVSTMQAAQ | EFIPKNMSGD | VRGHRYKWKE | 
    2750:
    CELRGERLKS | KESQFHKLKM | KDLKDSSIEM | ELRKVASAIE | EAALHPSELL | 
    2800:
    TNMEDEDDTD | ETLTSLLNEI | AFLNQQLNDD | SGLAELSGSM | DTEFSGDAQR | 
    2850:
    AFISKLAPGN | RSAFQVGHLG | AGVKELPDVQ | EESESISPLL | LHLEDDDFSE | 
    2900:
    NEKQLGDTAS | EPDVLKIVID | PEIKDSLVSH | RKSSDGGQST | SGLPAEPESV | 
    2950:
    SSPPILHMKT | GPENSNTDTL | WRPMPKLAPL | GLKVANPPSD | ADGQSLKVMP | 
    3000:
    ALAPIAAKVG | SIGHKMNLAG | IDQEGRGSKV | MPTLAPVVPK | LGNSGAPSSS | 
    3003:
    SGK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MAX gene-associated protein
    ELISA Kit for Mouse MAX gene-associated protein
    CLIA Kit for Mouse MAX gene-associated protein
    CLIA Kit for Mouse MAX gene-associated protein
    Polyclonal Antibody for Mouse MAX gene-associated protein
    Polyclonal Antibody for Mouse MAX gene-associated protein
    Monoclonal Antibody for Mouse MAX gene-associated protein
    Monoclonal Antibody for Mouse MAX gene-associated protein
    Protein for Mouse MAX gene-associated protein
    Protein for Mouse MAX gene-associated protein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif."
      Hurlin P.J. , Steingrimsson E. , Copeland N.G. , Jenkins N.A. , Eisenman R.N.
      EMBO J.18:7019-7028(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1129 (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1129 (ISOFORM 3)
      strain: C57BL/6J.
      tissue: Colon.
      tissue: Corpora quadrigemina.
      tissue: Embryo.
      tissue: Olfactory bulb.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Seino S. , Nishimura M. , Kaisho T. , Hoshino K. , Kitamura H. , Nagase T. , Ohara O. , Koga H.
      DNA Res.11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-2465 (ISOFORM 2)
      tissue: Thymus.
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