Gene name:
MIB1 (DIP1;KIAA1323;ZZANK2) ;
Protein name:
E3 ubiquitin-protein ligase MIB1 ;
Alternative:
Mind bomb homolog 1 ;DAPK-interacting protein 1 (DIP-1) ;Zinc finger ZZ type with ankyrin repeat domain protein 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Subcellular Location:
Cytoplasm
Cell membrane
Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear.
Protein Attributes:
50:
MSNSRNNRVM | VEGVGARVVR | GPDWKWGKQD | GGEGHVGTVR | SFESPEEVVV |
100:
VWDNGTAANY | RCSGAYDLRI | LDSAPTGIKH | DGTMCDTCRQ | QPIIGIRWKC |
150:
AECTNYDLCT | VCYHGDKHHL | RHRFYRITTP | GSERVLLESR | RKSKKITARG |
200:
IFAGARVVRG | VDWQWEDQDG | GNGRRGKVTE | IQDWSASSPH | SAAYVLWDNG |
250:
AKNLYRVGFE | GMSDLKCVQD | AKGGSFYRDH | CPVLGEQNGN | RNPGGLQIGD |
300:
LVNIDLDLEI | VQSLQHGHGG | WTDGMFETLT | TTGTVCGIDE | DHDIVVQYPS |
350:
GNRWTFNPAV | LTKANIVRSG | DAAQGAEGGT | SQFQVGDLVQ | VCYDLERIKL |
400:
LQRGHGEWAE | AMLPTLGKVG | RVQQIYSDSD | LKVEVCGTSW | TYNPAAVSKV |
450:
ASAGSAISNA | SGERLSQLLK | KLFETQESGD | LNEELVKAAA | NGDVAKVEDL |
500:
LKRPDVDVNG | QCAGHTAMQA | ASQNGHVDIL | KLLLKQNVDV | EAEDKDGDRA |
550:
VHHAAFGDEG | AVIEVLHRGS | ADLNARNKRR | QTPLHIAVNK | GHLQVVKTLL |
600:
DFGCHPSLQD | SEGDTPLHDA | ISKKRDDILA | VLLEAGADVT | ITNNNGFNAL |
650:
HHAALRGNPS | AMRVLLSKLP | RPWIVDEKKD | DGYTALHLAA | LNNHVEVAEL |
700:
LVHQGNANLD | IQNVNQQTAL | HLAVERQHTQ | IVRLLVRAGA | KLDIQDKDGD |
750:
TPLHEALRHH | TLSQLRQLQD | MQDVGKVDAA | WEPSKNTLIM | GLGTQGAEKK |
800:
SAASIACFLA | ANGADLSIRN | KKGQSPLDLC | PDPNLCKALA | KCHKEKVSGQ |
850:
VGSRSPSMIS | NDSETLEECM | VCSDMKRDTL | FGPCGHIATC | SLCSPRVKKC |
900:
LICKEQVQSR | TKIEECVVCS | DKKAAVLFQP | CGHMCACENC | ANLMKKCVQC |
950:
RAVVERRVPF | IMCCGGKSSE | DATDDISSGN | IPVLQKDKDN | TNVNADVQKL |
1000:
QQQLQDIKEQ | TMCPVCLDRL | KNMIFLCGHG | TCQLCGDRMS | ECPICRKAIE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human E3 ubiquitin-protein ligase MIB1
ELISA Kit for Human E3 ubiquitin-protein ligase MIB1
CLIA Kit for Human E3 ubiquitin-protein ligase MIB1
CLIA Kit for Human E3 ubiquitin-protein ligase MIB1
Polyclonal Antibody for Human E3 ubiquitin-protein ligase MIB1
Polyclonal Antibody for Human E3 ubiquitin-protein ligase MIB1
Monoclonal Antibody for Human E3 ubiquitin-protein ligase MIB1
Monoclonal Antibody for Human E3 ubiquitin-protein ligase MIB1
Protein for Human E3 ubiquitin-protein ligase MIB1
Protein for Human E3 ubiquitin-protein ligase MIB1
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 627-1006
tissue :
Placenta .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POSSIBLE SUBCELLULAR LOCATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION OF TBK1
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LVNC7 PHE-943