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Index > Protein center > MIB1(Gene name) > Human
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  • MIB1 (Gene name),
  • E3 ubiquitin-protein ligase MIB1 (Protein name ),  MIB1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    MIB1(DIP1;KIAA1323;ZZANK2);
    Protein name:
    E3 ubiquitin-protein ligase MIB1;
    Alternative:
    Mind bomb homolog 1;DAPK-interacting protein 1(DIP-1);Zinc finger ZZ type with ankyrin repeat domain protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
    Subcellular Location:
    Cytoplasm Cell membrane Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear.
    Protein Attributes:
    Sequence length:
    1006
    Sequence:
    50:
    MSNSRNNRVM | VEGVGARVVR | GPDWKWGKQD | GGEGHVGTVR | SFESPEEVVV | 
    100:
    VWDNGTAANY | RCSGAYDLRI | LDSAPTGIKH | DGTMCDTCRQ | QPIIGIRWKC | 
    150:
    AECTNYDLCT | VCYHGDKHHL | RHRFYRITTP | GSERVLLESR | RKSKKITARG | 
    200:
    IFAGARVVRG | VDWQWEDQDG | GNGRRGKVTE | IQDWSASSPH | SAAYVLWDNG | 
    250:
    AKNLYRVGFE | GMSDLKCVQD | AKGGSFYRDH | CPVLGEQNGN | RNPGGLQIGD | 
    300:
    LVNIDLDLEI | VQSLQHGHGG | WTDGMFETLT | TTGTVCGIDE | DHDIVVQYPS | 
    350:
    GNRWTFNPAV | LTKANIVRSG | DAAQGAEGGT | SQFQVGDLVQ | VCYDLERIKL | 
    400:
    LQRGHGEWAE | AMLPTLGKVG | RVQQIYSDSD | LKVEVCGTSW | TYNPAAVSKV | 
    450:
    ASAGSAISNA | SGERLSQLLK | KLFETQESGD | LNEELVKAAA | NGDVAKVEDL | 
    500:
    LKRPDVDVNG | QCAGHTAMQA | ASQNGHVDIL | KLLLKQNVDV | EAEDKDGDRA | 
    550:
    VHHAAFGDEG | AVIEVLHRGS | ADLNARNKRR | QTPLHIAVNK | GHLQVVKTLL | 
    600:
    DFGCHPSLQD | SEGDTPLHDA | ISKKRDDILA | VLLEAGADVT | ITNNNGFNAL | 
    650:
    HHAALRGNPS | AMRVLLSKLP | RPWIVDEKKD | DGYTALHLAA | LNNHVEVAEL | 
    700:
    LVHQGNANLD | IQNVNQQTAL | HLAVERQHTQ | IVRLLVRAGA | KLDIQDKDGD | 
    750:
    TPLHEALRHH | TLSQLRQLQD | MQDVGKVDAA | WEPSKNTLIM | GLGTQGAEKK | 
    800:
    SAASIACFLA | ANGADLSIRN | KKGQSPLDLC | PDPNLCKALA | KCHKEKVSGQ | 
    850:
    VGSRSPSMIS | NDSETLEECM | VCSDMKRDTL | FGPCGHIATC | SLCSPRVKKC | 
    900:
    LICKEQVQSR | TKIEECVVCS | DKKAAVLFQP | CGHMCACENC | ANLMKKCVQC | 
    950:
    RAVVERRVPF | IMCCGGKSSE | DATDDISSGN | IPVLQKDKDN | TNVNADVQKL | 
    1000:
    QQQLQDIKEQ | TMCPVCLDRL | KNMIFLCGHG | TCQLCGDRMS | ECPICRKAIE | 
    1006:
    RRILLY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    KEGG:
    UniGene:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase MIB1
    ELISA Kit for Human E3 ubiquitin-protein ligase MIB1
    CLIA Kit for Human E3 ubiquitin-protein ligase MIB1
    CLIA Kit for Human E3 ubiquitin-protein ligase MIB1
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MIB1
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MIB1
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MIB1
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MIB1
    Protein for Human E3 ubiquitin-protein ligase MIB1
    Protein for Human E3 ubiquitin-protein ligase MIB1

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta."
      Itoh M. , Kim C.-H. , Palardy G. , Oda T. , Jiang Y.-J. , Maust D. , Yeo S.-Y. , Lorick K. , Wright G.J. , Ariza-McNaughton L. , Weissman A.M. , Lewis J. , Chandrasekharappa S.C. , Chitnis A.B.
      Dev. Cell4:67-82(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      Yoo K.-W. , Chitnis A. , Kim C.-H.
      Submitted (2002-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-1006
      tissue: Amygdala.
      tissue: Endometrial tumor.
    6. 6.
      "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 611-1006;TISSUE SPECIFICITY
      tissue: Brain.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 627-1006
      tissue: Placenta.
    8. 8.
      "Death-associated protein kinase expression in human temporal lobe epilepsy."
      Henshall D.C. , Schindler C.K. , So N.K. , Lan J.-Q. , Meller R. , Simon R.P.
      Ann. Neurol.55:485-494(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE SUBCELLULAR LOCATION
    9. 9.
      "Mapping a dynamic innate immunity protein interaction network regulating type I interferon production."
      Li S. , Wang L. , Berman M. , Kong Y.Y. , Dorf M.E.
      Immunity35:426-440(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION OF TBK1
    10. 10.
      "A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis."
      Villumsen B.H. , Danielsen J.R. , Povlsen L. , Sylvestersen K.B. , Merdes A. , Beli P. , Yang Y.G. , Choudhary C. , Nielsen M.L. , Mailand N. , Bekker-Jensen S.
      EMBO J.32:3029-3040(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF CEP131 AND PCM1;FUNCTION IN CILIOGENESIS;UBIQUITINATION;INTERACTION WITH CEP131 AND PCM1;SUBCELLULAR LOCATION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-174
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LVNC7 PHE-943
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