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Index > Protein center > Mib1(Gene name) > Mouse
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  • Mib1 (Gene name),
  • E3 ubiquitin-protein ligase MIB1 (Protein name ),  MIB1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Mib1(Dip1;Kiaa1323;Mib);
    Protein name:
    E3 ubiquitin-protein ligase MIB1;
    Alternative:
    Mind bomb homolog 1;DAPK-interacting protein 1(DIP-1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity). Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
    Subcellular Location:
    Cytoplasm Cell membrane Localizes to the plasma membrane.
    Protein Attributes:
    Sequence length:
    1006
    Sequence:
    50:
    MSNSRNNRVM | VEGVGARVVR | GPDWKWGKQD | GGEGHVGTVR | SFESPEEVVV | 
    100:
    VWDNGTAANY | RCSGAYDLRI | LDSAPTGIKH | DGTMCDTCRQ | QPIIGIRWKC | 
    150:
    AECTNYDLCT | VCYHGDKHHL | RHRFYRITTP | GSERVLLESR | RKSKKITARG | 
    200:
    IFAGARVVRG | VDWQWEDQDG | GNGRRGKVTE | IQDWSASSPH | SAAYVLWDNG | 
    250:
    AKNLYRVGFE | GMSDLKCVQD | AKGGSFYRDH | CPVLGEQNGN | RNPGGLQIGD | 
    300:
    LVNIDLDLEI | VQSLQHGHGG | WTDGMFETLT | TTGTVCGIDE | DHDIVVQYPS | 
    350:
    GNRWTFNPAV | LTKANIVRSG | DAAQGAEGGT | SQFQVGDLVQ | VCYDLERIKL | 
    400:
    LQRGHGEWAE | AMLPTLGKVG | RVQQIYSDSD | LKVEVCGTSW | TYNPAAVSKV | 
    450:
    APAGSAISNA | SGERLSQLLK | KLFETQESGD | LNEELVKAAA | NGDVAKVEDL | 
    500:
    LKRPDVDVNG | QCAGHTAMQA | ASQNGHVDIL | KLLLKQNVDV | EAEDKDGDRA | 
    550:
    VHHAAFGDEG | AVIEVLHRGS | ADLNARNKRR | QTPLHIAVNK | GHLQVVKTLL | 
    600:
    DFGCHPSLQD | SEGDTPLHDA | ISKKRDDILA | VLLEAGADVT | ITNNNGFNAL | 
    650:
    HHAALRGNPS | AMRVLLSKLP | RPWIVDEKKD | DGYTALHLAA | LNNHVEVAEL | 
    700:
    LVHQGNANLD | IQNVNQQTAL | HLAVERQHTQ | IVRLLVRAGA | KLDIQDKDGD | 
    750:
    TPLHEALRHH | TLSQLRQLQD | MQDVGKVDAA | WEPSKNTLIM | GLGTQGAEKK | 
    800:
    SAASIACFLA | ANGADLSIRN | KKGQSPLDLC | PDPSLCKALA | KCHKEKVSGQ | 
    850:
    VGSRSPSMIS | NDSETLEECM | VCSDMKRDTL | FGPCGHIATC | SLCSPRVKKC | 
    900:
    LICKEQVQSR | TKIEECVVCS | DKKAAVLFQP | CGHMCACENC | ASLMKKCVQC | 
    950:
    RAVVERRVPF | ITCCGGKSSE | DPSDEISSGN | IPVLQKDKDN | TNVNADVQKL | 
    1000:
    QQQLQDIKEQ | TMCPVCLDRL | KNMIFLCGHG | TCQLCGDRMS | ECPICRKAIE | 
    1006:
    RRILLY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase MIB1
    ELISA Kit for Mouse E3 ubiquitin-protein ligase MIB1
    CLIA Kit for Mouse E3 ubiquitin-protein ligase MIB1
    CLIA Kit for Mouse E3 ubiquitin-protein ligase MIB1
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase MIB1
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase MIB1
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase MIB1
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase MIB1
    Protein for Mouse E3 ubiquitin-protein ligase MIB1
    Protein for Mouse E3 ubiquitin-protein ligase MIB1

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK."
      Jin Y. , Blue E.K. , Dixon S. , Shao Z. , Gallagher P.J.
      J. Biol. Chem.277:46980-46986(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;UBIQUITINATION
      tissue: Urinary bladder.
    2. 2.
      "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta."
      Itoh M. , Kim C.-H. , Palardy G. , Oda T. , Jiang Y.-J. , Maust D. , Yeo S.-Y. , Lorick K. , Wright G.J. , Ariza-McNaughton L. , Weissman A.M. , Lewis J. , Chandrasekharappa S.C. , Chitnis A.B.
      Dev. Cell4:67-82(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C3H.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;UBIQUITINATION
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 349-1006
      strain: C57BL/6J.
      tissue: Corpora quadrigemina.
      tissue: Head.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 547-1006
      strain: 129.
      strain: FVB/N.
      tissue: Embryo.
      tissue: Mammary tumor.
    6. 6.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 864-1006
      tissue: Embryonic tail.
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