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Index > Protein center > MIB2(Gene name) > Human
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  • MIB2 (Gene name),
  • E3 ubiquitin-protein ligase MIB2 (Protein name ),  MIB2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MIB2(SKD;ZZANK1);
    Protein name:
    E3 ubiquitin-protein ligase MIB2;
    Alternative:
    Novel zinc finger protein(Novelzin);Mind bomb homolog 2;Skeletrophin;Putative NF-kappa-B-activating protein 002N;Zinc finger ZZ type with ankyrin repeat domain protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with actin monomer.
    Function:
    E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
    Subcellular Location:
    Cytoplasm Endosome Colocalizes with endosomal compartments.
    Protein Attributes:
    Sequence length:
    1013
    Sequence:
    50:
    MGWKPSEARG | QSQSFQASGL | QPRSLKAARR | ATGRPDRSRA | ARPTMDPSAH | 
    100:
    RSRAAPPNMD | PDPQAGVQVG | MRVVRGVDWK | WGQQDGGEGG | VGTVVELGRH | 
    150:
    GSPSTPDRTV | VVQWDQGTRT | NYRAGYQGAH | DLLLYDNAQI | GVRHPNIICD | 
    200:
    CCKKHGLRGM | RWKCRVCLDY | DLCTQCYMHN | KHELAHAFDR | YETAHSRPVT | 
    250:
    LSPRQGLPRI | PLRGIFQGAK | VVRGPDWEWG | SQDGGEGKPG | RVVDIRGWDV | 
    300:
    ETGRSVASVT | WADGTTNVYR | VGHKGKVDLK | CVGEAAGGFY | YKDHLPRLGK | 
    350:
    PAELQRRVSA | DSQPFQHGDK | VKCLLDTDVL | REMQEGHGGW | NPRMAEFIGQ | 
    400:
    TGTVHRITDR | GDVRVQFNHE | TRWTFHPGAL | TKHHSFWVGD | VVRVIGDLDT | 
    450:
    VKRLQAGHGE | WTDDMAPALG | RVGKVVKVFG | DGNLRVAVAG | QRWTFSPSCL | 
    500:
    VAYRPEEDAN | LDVAERAREN | KSSLSVALDK | LRAQKSDPEH | PGRLVVEVAL | 
    550:
    GNAARALDLL | RRRPEQVDTK | NQGRTALQVA | AYLGQVELIR | LLLQARAGVD | 
    600:
    LPDDEGNTAL | HYAALGNQPE | ATRVLLSAGC | RADAINSTQS | TALHVAVQRG | 
    650:
    FLEVVRALCE | RGCDVNLPDA | HSDTPLHSAI | SAGTGASGIV | EVLTEVPNID | 
    700:
    VTATNSQGFT | LLHHASLKGH | ALAVRKILAR | ARQLVDAKKE | DGFTALHLAA | 
    750:
    LNNHREVAQI | LIREGRCDVN | VRNRKLQSPL | HLAVQQAHVG | LVPLLVDAGC | 
    800:
    SVNAEDEEGD | TALHVALQRH | QLLPLVADGA | GGDPGPLQLL | SRLQASGLPG | 
    850:
    SAELTVGAAV | ACFLALEGAD | VSYTNHRGRS | PLDLAAEGRV | LKALQGCAQR | 
    900:
    FRERQAGGGA | APGPRQTLGT | PNTVTNLHVG | AAPGPEAAEC | LVCSELALLV | 
    950:
    LFSPCQHRTV | CEECARRMKK | CIRCQVVVSK | KLRPDGSEVA | SAAPAPGPPR | 
    1000:
    QLVEELQSRY | RQMEERITCP | ICIDSHIRLV | FQCGHGACAP | CGSALSACPI | 
    1013:
    CRQPIRDRIQ | IFV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase MIB2
    ELISA Kit for Human E3 ubiquitin-protein ligase MIB2
    ELISA Kit for Human E3 ubiquitin-protein ligase MIB2
    ELISA Kit for Human E3 ubiquitin-protein ligase MIB2
    CLIA Kit for Human E3 ubiquitin-protein ligase MIB2
    CLIA Kit for Human E3 ubiquitin-protein ligase MIB2
    CLIA Kit for Human E3 ubiquitin-protein ligase MIB2
    CLIA Kit for Human E3 ubiquitin-protein ligase MIB2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MIB2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MIB2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MIB2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MIB2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MIB2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MIB2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MIB2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MIB2
    Protein for Human E3 ubiquitin-protein ligase MIB2
    Protein for Human E3 ubiquitin-protein ligase MIB2
    Protein for Human E3 ubiquitin-protein ligase MIB2
    Protein for Human E3 ubiquitin-protein ligase MIB2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma."
      Takeuchi T. , Heng H.H.Q. , Ye C.J. , Liang S.-B. , Iwata J. , Sonobe H. , Ohtsuki Y.
      Am. J. Pathol.163:1395-1404(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION;INTERACTION WITH ACTIN;VARIANT THR-45
    2. 2.
      "A novel zinc finger protein."
      Takeuchi T.
      Submitted (2002-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);VARIANT THR-45
    3. 3.
      "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A. , Suzuki Y. , Honda G. , Muramatsu S. , Matsuzaki O. , Nagano Y. , Doi T. , Shimotohno K. , Harada T. , Nishida E. , Hayashi H. , Sugano S.
      Oncogene22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT LEU-15
      tissue: Lung fibroblast.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7; 8; 9; 10 AND 11);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-1013 (ISOFORM 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-1013 (ISOFORMS 1/2/6/7);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 327-1013 (ISOFORM 4);VARIANTS LEU-15 AND THR-45
      tissue: Brain.
      tissue: Heart.
      tissue: Spleen.
      tissue: Teratocarcinoma.
      tissue: Testis.
      tissue: Tongue.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
      tissue: Lymph.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-1013 (ISOFORMS 1/2)
      tissue: Testis.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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