Spen ELISA Kit for Mouse(Mus musculus) | EIAab.comSpen ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Spen(Gene name) > Mouse

Spen (Gene name),

Msx2-interacting protein (Protein name ), MINT_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Spen(Kiaa0929;Mint;Sharp);

Protein name:

Msx2-interacting protein;

Alternative:

SPEN homolog;SMART/HDAC1-associated repressor protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and MTA1L1. Interacts with the nuclear receptors RAR and PPARD. Interacts with RAR in absence of ligand. Binds to the steroid receptor RNA coactivator SRA (By similarity). Interacts with MSX2. Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and NOTCH1. Binds to HIPK3.

Function:

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways, such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.

Subcellular Location:

Nucleus Associates with chromatin.

Protein Attributes:

Sequence length:

3644

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QPAYVLQIFP | PCEFSESHLS | RLAPDLLASI | SNISPHLMIV | IASV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q62504

KEGG:

mmu:56381

UniGene:

Mm.299906

SMR:

Q62504

Pfam:

PF00076

Uniprot:

Q62504

FOR

ELISA Kit for Mouse Msx2-interacting protein

CLIA Kit for Mouse Msx2-interacting protein

Polyclonal Antibody for Mouse Msx2-interacting protein

Monoclonal Antibody for Mouse Msx2-interacting protein

Protein for Mouse Msx2-interacting protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-112
strain: C57BL/6J.
tissue: Egg.
2.

"The RRM domain of MINT, a novel msx2 binding protein, recognizes and regulates the rat osteocalcin promoter."
Newberry E.P. , Latifi T. , Towler D.A.
Biochemistry38:10678-10690(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-3644 (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DNA-BINDING;INTERACTION WITH MSX2
tissue: Testis.
3.

"MINT/spen negatively regulates Notch signaling by inhibiting RBP-J/Su(H) activity."
Sakamoto T. , Gotou T. , Isagawa Y. , Mimura H. , Kimura K. , Kawaichi M.
Submitted (2001-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-3644 (ISOFORM 2);VARIANTS THR-348; PHE-762; PHE-773 AND LEU-933
strain: ICR.
tissue: Brain.
4.

"Cloning of the genes encoding two murine and human cochlear unconventional type I myosins."
Crozet F. , El-Amraoui A. , Blanchard S. , Lenoir M. , Ripoll C. , Vago P. , Hamel C. , Fizames C. , Levi-Acobas F. , Depetris D. , Mattei M.-G. , Weil D. , Pujol R. , Petit C.
Genomics40:332-341(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-578;VARIANT THR-348
tissue: Cochlea.
5.

"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2600-3644 (ISOFORM 3)
tissue: Brain.
6.

Okazaki N. , Kikuno R. , Nagase T. , Ohara O. , Koga H.
Submitted (2003-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
7.

"SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway."
Oswald F. , Kostezka U. , Astrahantseff K. , Bourteele S. , Dillinger K. , Zechner U. , Ludwig L. , Wilda M. , Hameister H. , Knoechel W. , Liptay S. , Schmid R.M.
EMBO J.21:5417-5426(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
8.

"Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway."
Kuroda K. , Han H. , Tani S. , Tanigaki K. , Tun T. , Furukawa T. , Taniguchi Y. , Kurooka H. , Hamada Y. , Toyokuni S. , Honjo T.
Immunity18:301-312(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
9.

"MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element."
Sierra O.L. , Cheng S.L. , Loewy A.P. , Charlton-Kachigian N. , Towler D.A.
J. Biol. Chem.279:32913-32923(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
11.

"Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3."
Sierra O.L. , Towler D.A.
Mol. Endocrinol.24:1478-1497(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HIPK3

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