Mitogen-activated protein kinase 1 (Protein name
), MK01_BOVIN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
MAPK1(ERK2;PRKM1);
Protein name:
Mitogen-activated protein kinase 1(MAP kinase 1;MAPK 1);
Alternative:
Extracellular signal-regulated kinase 2(ERK-2);ERT1;Mitogen-activated protein kinase 2(MAP kinase 2;MAPK 2);
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts with ARHGEF2, NISCH, MORG1 and HSF4 (By similarity). Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with ARRB2 (By similarity). Interacts with ADAM15 (By similarity). Interacts with NEK2.
Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.
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Precision
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Recovery
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Linearity
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References
1.
"Cloning and sequencing of ERK2 from a bovine adrenal medulla cDNA library." Ely C.M.
,
Cox M.E.
,
Her J.
,
Parsons S.J.
Submitted (1992-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]