MAPK8 ELISA Kit for Human(Homo sapiens) | EIAab.comMAPK8 ELISA Kit for Human(Homo sapiens)

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MAPK8 (Gene name),

Mitogen-activated protein kinase 8 (Protein name ), MK08_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MAPK8(JNK1;PRKM8;SAPK1;SAPK1C);

Protein name:

Mitogen-activated protein kinase 8(MAP kinase 8;MAPK 8);

Alternative:

Stress-activated protein kinase 1(SAPK1c);JNK-46;c-Jun N-terminal kinase 1;Stress-activated protein kinase JNK1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and RGNEF (By similarity). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity). Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling.

Function:

JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

427

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

427:

SMSTDPTLAS | DTDSSLEAAA | GPLGCCR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P45983

String:

P45983

KEGG:

hsa:5599

MIM:

601158

UniGene:

Hs.138211

Pfam:

PF00069

STRING:

9606.ENSP00000353483

Uniprot:

P45983

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ELISA Kit for Human MAP kinase 8

Cat.:

E9092m

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96T

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ELISA Kit for Human MAP kinase 8

Cat.:

E9092r

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96T

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ELISA Kit for Human MAP kinase 8

Cat.:

E9092h

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96T

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CLIA Kit for Human MAP kinase 8

Cat.:

U9092h

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human MAP kinase 8

Cat.:

U9092r

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human MAP kinase 8

Cat.:

U9092m

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96T

Polyclonal Antibody for Human MAP kinase 8

Cat.:

P9092Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MAP kinase 8

Cat.:

P9092Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MAP kinase 8

Monoclonal Antibody for Human MAP kinase 8

Protein for Human MAP kinase 8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain."
Derijard B. , Hibi M. , Wu I.-H. , Barrett T. , Su B. , Deng T. , Karin M. , Davis R.J.
Cell76:1025-1037(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fetal brain.
2.

"Selective interaction of JNK protein kinase isoforms with transcription factors."
Gupta S. , Barrett T. , Whitmarsh A.J. , Cavanagh J. , Sluss H.K. , Derijard B. , Davis R.J.
EMBO J.15:2760-2770(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
tissue: Brain.
3.

Lin L. , Nong W. , Zhou G. , Ke R. , Shen C. , Zhong G. , Zheng Z. , Liang M. , Tang Z. , Huang B. , Li H. , Yang S.
Submitted (2005-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
4.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
8.

"Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms."
Derijard B. , Raingeaud J. , Barrett T. , Wu I.-H. , Han J. , Ulevitch R.J. , Davis R.J.
Science267:682-685(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
9.

"Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7."
Fleming Y. , Armstrong C.G. , Morrice N. , Paterson A. , Goedert M. , Cohen P.
Biochem. J.352:145-154(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-183 AND TYR-185;REGULATION BY MAP2K4 AND MAP2K7;COFACTOR
10.

"The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death."
Kurokawa M. , Mitani K. , Yamagata T. , Takahashi T. , Izutsu K. , Ogawa S. , Moriguchi T. , Nishida E. , Yazaki Y. , Hirai H.
EMBO J.19:2958-2968(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MECOM
11.

"JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis."
Chang N.-S. , Doherty J. , Ensign A.
J. Biol. Chem.278:9195-9202(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WWOX AND TP53
12.

"Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein."
Jagadish N. , Rana R. , Selvi R. , Mishra D. , Garg M. , Yadav S. , Herr J.C. , Okumura K. , Hasegawa A. , Koyama K. , Suri A.
Biochem. J.389:73-82(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPAG9
13.

"Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26."
Hu Y. , Mivechi N.F.
Mol. Cell. Biol.26:3282-3294(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HSF4
14.

"Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation."
Yao K. , Cho Y.-Y. , Bergen H.R. III , Madden B.J. , Choi B.Y. , Ma W.-Y. , Bode A.M. , Dong Z.
Cancer Res.67:8725-8735(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFATC4
15.

"Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing."
Zihni C. , Mitsopoulos C. , Tavares I.A. , Baum B. , Ridley A.J. , Morris J.D.
J. Biol. Chem.282:6484-6493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY TAOK2
16.

"Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1."
Zhang L. , Yang S.H. , Sharrocks A.D.
Mol. Cell. Biol.27:2861-2869(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ELK1
17.

"Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."
Murata T. , Shinozuka Y. , Obata Y. , Yokoyama K.K.
Anal. Biochem.376:115-121(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF JDP2
18.

"JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy."
Wei Y. , Pattingre S. , Sinha S. , Bassik M. , Levine B.
Mol. Cell30:678-688(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF BCL2
19.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377 (ISOFORMS 1 AND 3);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"Crystal structure of SCCA1 and insight about the interaction with JNK1."
Zheng B. , Matoba Y. , Kumagai T. , Katagiri C. , Hibino T. , Sugiyama M.
Biochem. Biophys. Res. Commun.380:143-147(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SERPINB3;ENZYME REGULATION
22.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377 (ISOFORMS 1 AND 3);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"JNK1 phosphorylates SIRT1 and promotes its enzymatic activity."
Nasrin N. , Kaushik V.K. , Fortier E. , Wall D. , Pearson K.J. , de Cabo R. , Bordone L.
PLoS ONE4:E8414-E8414(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SIRT1
24.

"JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis."
Tomlinson V. , Gudmundsdottir K. , Luong P. , Leung K.Y. , Knebel A. , Basu S.
Cell Death Dis.1:E29-E29(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF YAP1
25.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"A critical step for JNK activation: isomerization by the prolyl isomerase Pin1."
Park J.E. , Lee J.A. , Park S.G. , Lee D.H. , Kim S.J. , Kim H.J. , Uchida C. , Uchida T. , Park B.C. , Cho S.
Cell Death Differ.19:153-161(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIN1
27.

"Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells."
Deng H. , Zhang J. , Yoon T. , Song D. , Li D. , Lin A.
Int. J. Biochem. Cell Biol.43:409-415(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF BAD
28.

"Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis."
Wang J. , Tang R. , Lv M. , Wang Q. , Zhang X. , Guo Y. , Chang H. , Qiao C. , Xiao H. , Li X. , Li Y. , Shen B. , Zhang J.
Mol. Biol. Cell22:117-127(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
29.

"JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress."
Miotto B. , Struhl K.
Mol. Cell44:62-71(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDT1
30.

"Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125."
Heo Y.S. , Kim S.K. , Seo C.I. , Kim Y.K. , Sung B.J. , Lee H.S. , Lee J.I. , Park S.Y. , Kim J.H. , Hwang K.Y. , Hyun Y.L. , Jeon Y.H. , Ro S. , Cho J.M. , Lee T.G. , Yang C.H.
EMBO J.23:2185-2195(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-363
31.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-171 AND ARG-177

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