Mkrn1 ELISA Kit for Mouse(Mus musculus) | EIAab.comMkrn1 ELISA Kit for Mouse(Mus musculus)

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Mkrn1 (Gene name),

E3 ubiquitin-protein ligase makorin-1 (Protein name ), MKRN1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mkrn1;

Protein name:

E3 ubiquitin-protein ligase makorin-1;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with p53/TP53 and CDKN1A. Interacts with TERT, modulating telomer length homeostasis.

Function:

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase (By similarity). Has negative and positive effects on RNA polymerase II-dependent transcription.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

481

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

481:

LAAGGDDELT | DSEDEWDLFH | DELEDFYDLD | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000031985

String:

Q9QXP6

SMR:

Q9QXP6

UniGene:

Mm.270484

Pfam:

PF00097

Uniprot:

Q9QXP6

FOR

ELISA Kit for Mouse E3 ubiquitin-protein ligase makorin-1

CLIA Kit for Mouse E3 ubiquitin-protein ligase makorin-1

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase makorin-1

Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase makorin-1

Protein for Mouse E3 ubiquitin-protein ligase makorin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system."
Gray T.A. , Hernandez L. , Carey A.H. , Schaldach M.A. , Smithwick M.J. , Rus K. , Marshall Graves J.A. , Stewart C.L. , Nicholls R.D.
Genomics66:76-86(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
2.

"Identification of a new target molecule for a cascade therapy of polycystic kidney."
Yoshida N. , Yano Y. , Yoshiki A. , Ueno M. , Deguchi N. , Hirotsune S.
Hum. Cell16:65-72(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
3.

"An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene."
Hirotsune S. , Yoshida N. , Chen A. , Garrett L. , Sugiyama F. , Takahashi S. , Yagami K. , Wynshaw-Boris A. , Yoshiki A.
Nature423:91-96(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY A PSEUDOGENE;TISSUE SPECIFICITY
4.

"Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain."
Lee S. , Walker C.L. , Wevrick R.
Gene Expr. Patterns3:599-609(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans."
Gray T.A. , Wilson A. , Fortin P.J. , Nicholls R.D.
Proc. Natl. Acad. Sci. U.S.A.103:12039-12044(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 2);DISRUPTION PHENOTYPE
6.

"Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription."
Omwancha J. , Zhou X.-F. , Chen S.-Y. , Baslan T. , Fisher C.J. , Zheng Z. , Cai C. , Shemshedini L.
Endocrine29:363-373(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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