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Index > Protein center > MYL12B(Gene name) > Human
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  • MYL12B (Gene name),
  • Myosin regulatory light chain 12B (Protein name ),  ML12B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MYL12B(MRLC2;MYLC2B);
    Protein name:
    Myosin regulatory light chain 12B;
    Alternative:
    Myosin regulatory light chain 2-B, smooth muscle isoform;MLC-2A(MLC-2);Myosin regulatory light chain MRLC2;Myosin regulatory light chain 20 kDa(MLC20);SHUJUN-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Myosin is an hexamer of 2 heavy chains and 4 light chains.
    Function:
    Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    172
    Sequence:
    50:
    MSSKKAKTKT | TKKRPQRATS | NVFAMFDQSQ | IQEFKEAFNM | IDQNRDGFID | 
    100:
    KEDLHDMLAS | LGKNPTDAYL | DAMMNEAPGP | INFTMFLTMF | GEKLNGTDPE | 
    150:
    DVIRNAFACF | DEEATGTIQE | DYLRELLTTM | GDRFTDEEVD | ELYREAPIDK | 
    172:
    KGNFNYIEFT | RILKHGAKDK | DD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    Pfam:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Myosin regulatory light chain 12B
    ELISA Kit for Human Myosin regulatory light chain 12B
    ELISA Kit for Human Myosin regulatory light chain 12B
    ELISA Kit for Human Myosin regulatory light chain 12B
    CLIA Kit for Human Myosin regulatory light chain 12B
    CLIA Kit for Human Myosin regulatory light chain 12B
    CLIA Kit for Human Myosin regulatory light chain 12B
    CLIA Kit for Human Myosin regulatory light chain 12B
    Polyclonal Antibody for Human Myosin regulatory light chain 12B
    Polyclonal Antibody for Human Myosin regulatory light chain 12B
    Polyclonal Antibody for Human Myosin regulatory light chain 12B
    Polyclonal Antibody for Human Myosin regulatory light chain 12B
    Monoclonal Antibody for Human Myosin regulatory light chain 12B
    Monoclonal Antibody for Human Myosin regulatory light chain 12B
    Monoclonal Antibody for Human Myosin regulatory light chain 12B
    Monoclonal Antibody for Human Myosin regulatory light chain 12B
    Protein for Human Myosin regulatory light chain 12B
    Protein for Human Myosin regulatory light chain 12B
    Protein for Human Myosin regulatory light chain 12B
    Protein for Human Myosin regulatory light chain 12B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells."
      Iwasaki T. , Murata-Hori M. , Ishitobi S. , Hosoya H.
      Cell Struct. Funct.26:677-683(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PHOSPHORYLATION AT THR-19 AND SER-20;MUTAGENESIS OF 19-THR-SER-20
    2. 2.
      "Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells."
      Watanabe M. , Kohri M. , Takaishi M. , Horie R. , Higashihara M.
      J. Smooth Muscle Res.37:25-38(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
    3. 3.
      "Molecular cloning of a novel human myosin regulatory light chain."
      Fujiwara T. , Kawai A. , Shimizu F. , Shinomiya K. , Hirano H. , Okuno S. , Ozaki K. , Katagiri T. , Takeda S. , Kuga Y. , Shimada Y. , Nagata M. , Takaichi A. , Watanabe T. , Horie M. , Nakamura Y. , Takahashi E. , Hirai Y.
      Submitted (1995-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    4. 4.
      "Human myosin regulatory light chain cDNA homologous to the rat myosin regulatory light chain B (MLC-B)."
      Brodie S.G. , Rubin S.E. , Montoya G.D. , Garry P.J. , Williams T.M.
      Submitted (1995-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Construction of cDNA expression library from nasopharyngeal carcinoma tissue and screening of antigenic genes."
      Shu J. , Li G. , He X.
      Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Nasopharyngeal carcinoma.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    9. 9.
      "Activation of actin-activated MgATPase activity of myosin II by phosphorylation with MAPK-activated protein kinase-1b (RSK-2)."
      Suizu F. , Ueda K. , Iwasaki T. , Murata-Hori M. , Hosoya H.
      J. Biochem.128:435-440(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge."
      Fumoto K. , Uchimura T. , Iwasaki T. , Ueda K. , Hosoya H.
      Biochem. J.370:551-556(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-19 AND SER-20;MUTAGENESIS OF 19-THR-SER-20
    11. 11.
      "Myosin motors and not actin comets are mediators of the actin-based Golgi-to-endoplasmic reticulum protein transport."
      Duran J.M. , Valderrama F. , Castel S. , Magdalena J. , Tomas M. , Hosoya H. , Renau-Piqueras J. , Malhotra V. , Egea G.
      Mol. Biol. Cell14:445-459(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 19-THR-SER-20
    12. 12.
      "Epigallocatechin-3-O-gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67 kDa laminin receptor."
      Umeda D. , Tachibana H. , Yamada K.
      Biochem. Biophys. Res. Commun.333:628-635(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-19 AND SER-20
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ZIPK/DAPK3
    14. 14.
      "Smooth muscle type isoform of 20 kDa myosin light chain is expressed in monocyte/macrophage cell lineage."
      Higashihara M. , Watanabe M. , Usuda S. , Miyazaki K.
      J. Smooth Muscle Res.44:29-40(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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