MLF1 ELISA Kit for Bovine(Bos taurus) | EIAab.comMLF1 ELISA Kit for Bovine(Bos taurus)

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Index > Protein center > MLF1(Gene name) > Bovine

MLF1 (Gene name),

Myeloid leukemia factor 1 (Protein name ), MLF1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MLF1;

Protein name:

Myeloid leukemia factor 1;

Alternative:

Myelodysplasia-myeloid leukemia factor 1;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Interacts with MLF1IP. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53.

Function:

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Subcellular Location:

Cytoplasm Nucleus In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus.

Protein Attributes:

Sequence length:

270

Sequence:

50:

100:

150:

200:

250:

270:

SNVFVDKLNI | KGSPVKINKK |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF10248

STRING:

9913.ENSBTAP00000005403

UniGene:

Bt.21766

String:

Q32KY3

KEGG:

bta:533379

Uniprot:

Q32KY3

FOR

ELISA Kit for Bovine Myeloid leukemia factor 1

CLIA Kit for Bovine Myeloid leukemia factor 1

Polyclonal Antibody for Bovine Myeloid leukemia factor 1

Monoclonal Antibody for Bovine Myeloid leukemia factor 1

Protein for Bovine Myeloid leukemia factor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2005-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Crossbred X Angus.
tissue: Liver.

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