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Index > Protein center > Mmel1(Gene name) > Rat
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  • Mmel1 (Gene name),
  • Membrane metallo-endopeptidase-like 1 (Protein name ),  MMEL1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mmel1(Mell1;Nep2);
    Protein name:
    Membrane metallo-endopeptidase-like 1;
    Alternative:
    Neprilysin II(NEPII);NEP2(m);Neprilysin-2(NEP2;NL2);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificiy with MME and cleaves peptides at the same amide bond.
    Subcellular Location:
    Membrane Single-pass type II membrane protein Secreted A secreted form produced by proteollytic cleavage also exists.
    Protein Attributes:
    Sequence length:
    774
    Sequence:
    50:
    MGKSESSVGM | MERADNCGRR | RLGFVECGLL | VLLTLLLMGA | IVTLGVFYSI | 
    100:
    GKQLPLLNSL | LHVSRHERTV | VKRVLRDSSQ | KSDICTTPSC | VIAAARILQN | 
    150:
    MDQSKKPCDN | FYQYACGGWL | RHHVIPETNS | RYSVFDILRD | ELEVILKGVL | 
    200:
    EDSSVQHRPA | VEKAKTLYRS | CMNQSVIEKR | DSEPLLNVLD | MIGGWPVAMD | 
    250:
    KWNETMGPKW | ELERQLAVLN | SQFNRRVLID | LFIWNDDQNS | SRHVIYIDQP | 
    300:
    TLGMPSREYY | FKEDSHRVRE | AYLQFMTSVA | TMLRRDLNLP | GETDLVQEEM | 
    350:
    AQVLHLETHL | ANATVPQEKR | HDVTALYHRM | GLEELQERFG | LKGFNWTLFI | 
    400:
    QNVLSSVQVE | LLPNEEVVVY | GIPYLENLEE | IIDVFPAQTL | QNYLVWRLVL | 
    450:
    DRIGSLSQRF | KEARVDYRKA | LYGTTMEEVR | WRECVSYVNS | NMESAVGSLY | 
    500:
    IKRAFSKDSK | SIVSELIEKI | RSVFVDNLDE | LNWMDEESKK | KAQEKALNIR | 
    550:
    EQIGYPDYIL | EDNNRHLDEE | YSSLTFSEDL | YFENGLQNLK | NNAQRSLKKL | 
    600:
    REKVDQNLWI | IGAAVVNAFY | SPNRNLIVFP | AGILQPPFFS | KDQPQALNFG | 
    650:
    GIGMVIGHEI | THGFDDNGRN | FDKNGNMLDW | WSNFSARHFR | QQSQCMIYQY | 
    700:
    SNFSWELADN | QNVNGFSTLG | ENIADNGGVR | QAYKAYLQWL | AEGGRDQRLP | 
    750:
    GLNLTYAQLF | FINYAQVWCG | SYRPEFAIQS | IKTDVHSPLN | AQVLGSLQNL | 
    774:
    PGFSEAFHCP | RGSPMHPMNR | CRIW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Membrane metallo-endopeptidase-like 1
    Cat.:
    E2033h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Membrane metallo-endopeptidase-like 1
    Cat.:
    E2033r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Membrane metallo-endopeptidase-like 1
    Cat.:
    E2033m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Membrane metallo-endopeptidase-like 1
    Cat.:
    U2033h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Membrane metallo-endopeptidase-like 1
    Cat.:
    U2033m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Membrane metallo-endopeptidase-like 1
    Cat.:
    U2033r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Membrane metallo-endopeptidase-like 1
    Cat.:
    P2033Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Membrane metallo-endopeptidase-like 1
    Cat.:
    P2033Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Membrane metallo-endopeptidase-like 1
    Cat.:
    P2033Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Membrane metallo-endopeptidase-like 1
    Monoclonal Antibody for Rat Membrane metallo-endopeptidase-like 1
    Monoclonal Antibody for Rat Membrane metallo-endopeptidase-like 1
    Protein for Rat Membrane metallo-endopeptidase-like 1
    Protein for Rat Membrane metallo-endopeptidase-like 1
    Protein for Rat Membrane metallo-endopeptidase-like 1

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    Linearity
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    References
    1. 1.
      "Neprilysin II: a putative novel metalloprotease and its isoforms in CNS and testis."
      Ouimet T. , Facchinetti P. , Rose C. , Bonhomme M.-C. , Gros C. , Schwartz J.-C.
      Biochem. Biophys. Res. Commun.271:565-570(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    4. 4.
      "Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1."
      Facchinetti P. , Rose C. , Schwartz J.C. , Ouimet T.
      Neuroscience118:627-639(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    5. 5.
      "A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2."
      Voisin S. , Rognan D. , Gros C. , Ouimet T.
      J. Biol. Chem.279:46172-46181(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF ARG-131; SER-133; ASN-567 AND LEU-739
    6. 6.
      "Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin."
      Rose C. , Voisin S. , Gros C. , Schwartz J.-C. , Ouimet T.
      Biochem. J.363:697-705(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;BIOPHYSICOCHEMICAL PROPERTIES
    7. 7.
      "The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity."
      Voisin S. , Ouimet T.
      Biochem. Biophys. Res. Commun.335:356-360(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF PRO-751; PRO-764 AND TRP-774
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