MOBKL1B ELISA Kit for Human(Homo sapiens) | EIAab.comMOBKL1B ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MOBKL1B(Gene name) > Human

MOBKL1B (Gene name),

Mps one binder kinase activator-like 1B (Protein name ), MOL1B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

MOBKL1B(C2orf6;MOB4B;MOBK1B);

Protein name:

Mps one binder kinase activator-like 1B;

Alternative:

Mob1 homolog 1B;Mob1 alpha(Mob1A);Protein Mob4B;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.

Function:

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

216

Sequence:

50:

100:

150:

200:

216:

LAPLQELIEK | LGSKDR