Protein name:
Multiple PDZ domain protein ;
Alternative:
Multi-PDZ domain protein 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 (By similarity). Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with the adenovirus type 9 E4-ORF1 protein.
Function:
Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Apical cell membrane
Peripheral membrane protein
Cytoplasmic side
Cell junction
synapse
postsynaptic cell membrane
postsynaptic density
Cell projection
dendrite
Cell junction
synapse
Cell junction
tight junction
Cell junction
synapse
Cell junction
synapse
synaptosome
Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.
Protein Attributes:
50:
MLEAIDKNRA | LHAAERLQTK | LRERGDVANE | DKLSLLKSVL | QSPLFSQILS |
100:
LQTSVQQLKD | QVNIATSATS | NIEYAHVPHL | SPAVIPTLQN | ESFLLSPNNG |
150:
NLEALTGPGI | PHINGKPACD | EFDQLIKNMA | QGRHVEVFEL | LKPPSGGLGF |
200:
SVVGLRSENR | GELGIFVQEI | QEGSVAHRDG | RLKETDQILA | INGQALDQTI |
250:
THQQAISILQ | KAKDTVQLVI | ARGSLPQLVS | PIVSRSPSAA | STISAHSNPV |
300:
HWQHMETIEL | VNDGSGLGFG | IIGGKATGVI | VKTILPGGVA | DQHGRLCSGD |
350:
HILKIGDTDL | AGMSSEQVAQ | VLRQCGNRVK | LMIARGAIEE | RTAPTALGIT |
400:
LSSSPTSTPE | LRVDASTQKG | EESETFDVEL | TKNVQGLGIT | IAGYIGDKKL |
450:
EPSGIFVKSI | TKSSAVEHDG | RIQIGDQIIA | VDGTNLQGFT | NQQAVEVLRH |
500:
TGQTVLLTLM | RRGMKQEAEL | MSREDVTKDA | DLSPVNASII | KENYEKDEDF |
550:
LSSTRNTNIL | PTEEEGYPLL | SAEIEEIEDA | QKQEAALLTK | WQRIMGINYE |
600:
IVVAHVSKFS | ENSGLGISLE | ATVGHHFIRS | VLPEGPVGHS | GKLFSGDELL |
650:
EVNGITLLGE | NHQDVVNILK | ELPIEVTMVC | CRRTVPPTTQ | SELDSLDLCD |
700:
IELTEKPHVD | LGEFIGSSET | EDPVLAMTDA | GQSTEEVQAP | LAMWEAGIQH |
750:
IELEKGSKGL | GFSILDYQDP | IDPASTVIII | RSLVPGGIAE | KDGRLLPGDR |
800:
LMFVNDVNLE | NSSLEEAVEA | LKGAPSGTVR | IGVAKPLPLS | PEEGYVSAKE |
850:
DSFLYPPHSC | EEAGLADKPL | FRADLALVGT | NDADLVDEST | FESPYSPEND |
900:
SIYSTQASIL | SLHGSSCGDG | LNYGSSLPSS | PPKDVIENSC | DPVLDLHMSL |
950:
EELYTQNLLQ | RQDENTPSVD | ISMGPASGFT | INDYTPANAI | EQQYECENTI |
1000:
VWTESHLPSE | VISSAELPSV | LPDSAGKGSE | YLLEQSSLAC | NAECVMLQNV |
1050:
SKESFERTIN | IAKGNSSLGM | TVSANKDGLG | MIVRSIIHGG | AISRDGRIAI |
1100:
GDCILSINEE | STISVTNAQA | RAMLRRHSLI | GPDIKITYVP | AEHLEEFKIS |
1150:
LGQQSGRVMA | LDIFSSYTGR | DIPELPEREE | GEGEESELQN | TAYSNWNQPR |
1200:
RVELWREPSK | SLGISIVGGR | GMGSRLSNGE | VMRGIFIKHV | LEDSPAGKNG |
1250:
TLKPGDRIVE | VDGMDLRDAS | HEQAVEAIRK | AGNPVVFMVQ | SIINRPRKSP |
1300:
LPSLLHNLYP | KYNFSSTNPF | ADSLQINADK | APSQSESEPE | KAPLCSVPPP |
1350:
PPSAFAEMGS | DHTQSSASKI | SQDVDKEDEF | GYSWKNIRER | YGTLTGELHM |
1400:
IELEKGHSGL | GLSLAGNKDR | SRMSVFIVGI | DPNGAAGKDG | RLQIADELLE |
1450:
INGQILYGRS | HQNASSIIKC | APSKVKIIFI | RNKDAVNQMA | VCPGNAVEPL |
1500:
PSNSENLQNK | ETEPTVTTSD | AAVDLSSFKN | VQHLELPKDQ | GGLGIAISEE |
1550:
DTLSGVIIKS | LTEHGVAATD | GRLKVGDQIL | AVDDEIVVGY | PIEKFISLLK |
1600:
TAKMTVKLTI | HAENPDSQAV | PSAAGAASGE | KKNSSQSLMV | PQSGSPEPES |
1650:
IRNTSRSSTP | AIFASDPATC | PIIPGCETTI | EISKGRTGLG | LSIVGGSDTL |
1700:
LGAIIIHEVY | EEGAACKDGR | LWAGDQILEV | NGIDLRKATH | DEAINVLRQT |
1750:
PQRVRLTLYR | DEAPYKEEEV | CDTLTIELQK | KPGKGLGLSI | VGKRNDTGVF |
1800:
VSDIVKGGIA | DADGRLMQGD | QILMVNGEDV | RNATQEAVAA | LLKCSLGTVT |
1850:
LEVGRIKAGP | FHSERRPSQS | SQVSEGSLSS | FTFPLSGSST | SESLESSSKK |
1900:
NALASEIQGL | RTVEMKKGPT | DSLGISIAGG | VGSPLGDVPI | FIAMMHPTGV |
1950:
AAQTQKLRVG | DRIVTICGTS | TEGMTHTQAV | NLLKNASGSI | EMQVVAGGDV |
2000:
SVVTGHQQEP | ASSSLSFTGL | TSSSIFQDDL | GPPQCKSITL | ERGPDGLGFS |
2050:
IVGGYGSPHG | DLPIYVKTVF | AKGAASEDGR | LKRGDQIIAV | NGQSLEGVTH |
2070:
EEAVAILKRT | KGTVTLMVLS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Human Multiple PDZ domain protein
ELISA Kit for Human Multiple PDZ domain protein
ELISA Kit for Human Multiple PDZ domain protein
CLIA Kit for Human Multiple PDZ domain protein
CLIA Kit for Human Multiple PDZ domain protein
CLIA Kit for Human Multiple PDZ domain protein
Polyclonal Antibody for Human Multiple PDZ domain protein
Polyclonal Antibody for Human Multiple PDZ domain protein
Polyclonal Antibody for Human Multiple PDZ domain protein
Monoclonal Antibody for Human Multiple PDZ domain protein
Monoclonal Antibody for Human Multiple PDZ domain protein
Monoclonal Antibody for Human Multiple PDZ domain protein
Protein for Human Multiple PDZ domain protein
Protein for Human Multiple PDZ domain protein
Protein for Human Multiple PDZ domain protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 573-2070 (ISOFORM 1)
tissue :
Amygdala .
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Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
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Europe PMC ]
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Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1535-2070 (ISOFORM 1)
tissue :
Brain .
8.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1618-2070 (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH HTR2C;SUBCELLULAR LOCATION
tissue :
Brain .
9.
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Cited for : INTERACTION WITH ADENOVIRUS TYPE 9 E4-ORF1 PROTEIN
10.
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Cited for : INTERACTION WITH HTR2A; HTR2B AND HTR2C;DOMAIN;FUNCTION
11.
"Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo."
Kimber W.A.
,
Trinkle-Mulcahy L.
,
Cheung P.C.F.
,
Deak M.
,
Marsden L.J.
,
Kieloch A.
,
Watt S.
,
Javier R.T.
,
Gray A.
,
Downes C.P.
,
Lucocq J.M.
,
Alessi D.R.
Biochem. J.361:525-536(2002)
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PubMed ]
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Europe PMC ]
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Abstract ]
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Cited for : INTERACTION WITH PLEKHA1 AND PLEKHA2;DOMAIN
12.
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Cited for : INTERACTION WITH CXADR;SUBCELLULAR LOCATION
13.
"Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure."
van de Pavert S.A.
,
Kantardzhieva A.
,
Malysheva A.
,
Meuleman J.
,
Versteeg I.
,
Levelt C.
,
Klooster J.
,
Geiger S.
,
Seeliger M.W.
,
Rashbass P.
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Le Bivic A.
,
Wijnholds J.
J. Cell Sci.117:4169-4177(2004)
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PubMed ]
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Europe PMC ]
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Abstract ]
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Cited for : INTERACTION WITH CRB1;SUBCELLULAR LOCATION
14.
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Cited for : INTERACTION WITH SYNGAP1; CAMK2A AND CAMK2B;MUTAGENESIS OF 147-GLY--PHE-150;DOMAIN;FUNCTION
15.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
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Cited for : INVOLVEMENT IN HYC2
20.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 117-227;X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 373-463;X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 1148-1243;X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1625-1716;X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1722-1806;X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1859-1951;X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 1983-2070