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Index > Protein center > MPDZ(Gene name) > Human
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  • MPDZ (Gene name),
  • Multiple PDZ domain protein (Protein name ),  MPDZ_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MPDZ(MUPP1);
    Protein name:
    Multiple PDZ domain protein;
    Alternative:
    Multi-PDZ domain protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 (By similarity). Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with the adenovirus type 9 E4-ORF1 protein.
    Function:
    Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Cytoplasmic side Apical cell membrane Peripheral membrane protein Cytoplasmic side Cell junction synapse postsynaptic cell membrane postsynaptic density Cell projection dendrite Cell junction synapse Cell junction tight junction Cell junction synapse Cell junction synapse synaptosome Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.
    Protein Attributes:
    Sequence length:
    2070
    Sequence:
    50:
    MLEAIDKNRA | LHAAERLQTK | LRERGDVANE | DKLSLLKSVL | QSPLFSQILS | 
    100:
    LQTSVQQLKD | QVNIATSATS | NIEYAHVPHL | SPAVIPTLQN | ESFLLSPNNG | 
    150:
    NLEALTGPGI | PHINGKPACD | EFDQLIKNMA | QGRHVEVFEL | LKPPSGGLGF | 
    200:
    SVVGLRSENR | GELGIFVQEI | QEGSVAHRDG | RLKETDQILA | INGQALDQTI | 
    250:
    THQQAISILQ | KAKDTVQLVI | ARGSLPQLVS | PIVSRSPSAA | STISAHSNPV | 
    300:
    HWQHMETIEL | VNDGSGLGFG | IIGGKATGVI | VKTILPGGVA | DQHGRLCSGD | 
    350:
    HILKIGDTDL | AGMSSEQVAQ | VLRQCGNRVK | LMIARGAIEE | RTAPTALGIT | 
    400:
    LSSSPTSTPE | LRVDASTQKG | EESETFDVEL | TKNVQGLGIT | IAGYIGDKKL | 
    450:
    EPSGIFVKSI | TKSSAVEHDG | RIQIGDQIIA | VDGTNLQGFT | NQQAVEVLRH | 
    500:
    TGQTVLLTLM | RRGMKQEAEL | MSREDVTKDA | DLSPVNASII | KENYEKDEDF | 
    550:
    LSSTRNTNIL | PTEEEGYPLL | SAEIEEIEDA | QKQEAALLTK | WQRIMGINYE | 
    600:
    IVVAHVSKFS | ENSGLGISLE | ATVGHHFIRS | VLPEGPVGHS | GKLFSGDELL | 
    650:
    EVNGITLLGE | NHQDVVNILK | ELPIEVTMVC | CRRTVPPTTQ | SELDSLDLCD | 
    700:
    IELTEKPHVD | LGEFIGSSET | EDPVLAMTDA | GQSTEEVQAP | LAMWEAGIQH | 
    750:
    IELEKGSKGL | GFSILDYQDP | IDPASTVIII | RSLVPGGIAE | KDGRLLPGDR | 
    800:
    LMFVNDVNLE | NSSLEEAVEA | LKGAPSGTVR | IGVAKPLPLS | PEEGYVSAKE | 
    850:
    DSFLYPPHSC | EEAGLADKPL | FRADLALVGT | NDADLVDEST | FESPYSPEND | 
    900:
    SIYSTQASIL | SLHGSSCGDG | LNYGSSLPSS | PPKDVIENSC | DPVLDLHMSL | 
    950:
    EELYTQNLLQ | RQDENTPSVD | ISMGPASGFT | INDYTPANAI | EQQYECENTI | 
    1000:
    VWTESHLPSE | VISSAELPSV | LPDSAGKGSE | YLLEQSSLAC | NAECVMLQNV | 
    1050:
    SKESFERTIN | IAKGNSSLGM | TVSANKDGLG | MIVRSIIHGG | AISRDGRIAI | 
    1100:
    GDCILSINEE | STISVTNAQA | RAMLRRHSLI | GPDIKITYVP | AEHLEEFKIS | 
    1150:
    LGQQSGRVMA | LDIFSSYTGR | DIPELPEREE | GEGEESELQN | TAYSNWNQPR | 
    1200:
    RVELWREPSK | SLGISIVGGR | GMGSRLSNGE | VMRGIFIKHV | LEDSPAGKNG | 
    1250:
    TLKPGDRIVE | VDGMDLRDAS | HEQAVEAIRK | AGNPVVFMVQ | SIINRPRKSP | 
    1300:
    LPSLLHNLYP | KYNFSSTNPF | ADSLQINADK | APSQSESEPE | KAPLCSVPPP | 
    1350:
    PPSAFAEMGS | DHTQSSASKI | SQDVDKEDEF | GYSWKNIRER | YGTLTGELHM | 
    1400:
    IELEKGHSGL | GLSLAGNKDR | SRMSVFIVGI | DPNGAAGKDG | RLQIADELLE | 
    1450:
    INGQILYGRS | HQNASSIIKC | APSKVKIIFI | RNKDAVNQMA | VCPGNAVEPL | 
    1500:
    PSNSENLQNK | ETEPTVTTSD | AAVDLSSFKN | VQHLELPKDQ | GGLGIAISEE | 
    1550:
    DTLSGVIIKS | LTEHGVAATD | GRLKVGDQIL | AVDDEIVVGY | PIEKFISLLK | 
    1600:
    TAKMTVKLTI | HAENPDSQAV | PSAAGAASGE | KKNSSQSLMV | PQSGSPEPES | 
    1650:
    IRNTSRSSTP | AIFASDPATC | PIIPGCETTI | EISKGRTGLG | LSIVGGSDTL | 
    1700:
    LGAIIIHEVY | EEGAACKDGR | LWAGDQILEV | NGIDLRKATH | DEAINVLRQT | 
    1750:
    PQRVRLTLYR | DEAPYKEEEV | CDTLTIELQK | KPGKGLGLSI | VGKRNDTGVF | 
    1800:
    VSDIVKGGIA | DADGRLMQGD | QILMVNGEDV | RNATQEAVAA | LLKCSLGTVT | 
    1850:
    LEVGRIKAGP | FHSERRPSQS | SQVSEGSLSS | FTFPLSGSST | SESLESSSKK | 
    1900:
    NALASEIQGL | RTVEMKKGPT | DSLGISIAGG | VGSPLGDVPI | FIAMMHPTGV | 
    1950:
    AAQTQKLRVG | DRIVTICGTS | TEGMTHTQAV | NLLKNASGSI | EMQVVAGGDV | 
    2000:
    SVVTGHQQEP | ASSSLSFTGL | TSSSIFQDDL | GPPQCKSITL | ERGPDGLGFS | 
    2050:
    IVGGYGSPHG | DLPIYVKTVF | AKGAASEDGR | LKRGDQIIAV | NGQSLEGVTH | 
    2070:
    EEAVAILKRT | KGTVTLMVLS | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    MIM:
    KEGG:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Multiple PDZ domain protein
    ELISA Kit for Human Multiple PDZ domain protein
    ELISA Kit for Human Multiple PDZ domain protein
    CLIA Kit for Human Multiple PDZ domain protein
    CLIA Kit for Human Multiple PDZ domain protein
    CLIA Kit for Human Multiple PDZ domain protein
    Polyclonal Antibody for Human Multiple PDZ domain protein
    Polyclonal Antibody for Human Multiple PDZ domain protein
    Polyclonal Antibody for Human Multiple PDZ domain protein
    Monoclonal Antibody for Human Multiple PDZ domain protein
    Monoclonal Antibody for Human Multiple PDZ domain protein
    Monoclonal Antibody for Human Multiple PDZ domain protein
    Protein for Human Multiple PDZ domain protein
    Protein for Human Multiple PDZ domain protein
    Protein for Human Multiple PDZ domain protein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human homolog of MUPP1 protein."
      Eng L. , Krapivinsky G. , Clapham D.E.
      Submitted (1998-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
      Nakajima D. , Saito K. , Yamakawa H. , Kikuno R.F. , Nakayama M. , Ohara R. , Okazaki N. , Koga H. , Nagase T. , Ohara O.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    3. 3.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 573-2070 (ISOFORM 1)
      tissue: Amygdala.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1535-2070 (ISOFORM 1)
      tissue: Brain.
    8. 8.
      "Cloning and characterization of MUPP1, a novel PDZ domain protein."
      Ullmer C. , Schmuck K. , Figge A. , Luebbert H.
      FEBS Lett.424:63-68(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1618-2070 (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH HTR2C;SUBCELLULAR LOCATION
      tissue: Brain.
    9. 9.
      "Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins."
      Lee S.S. , Glaunsinger B. , Mantovani F. , Banks L. , Javier R.T.
      J. Virol.74:9680-9693(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADENOVIRUS TYPE 9 E4-ORF1 PROTEIN
    10. 10.
      "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1."
      Becamel C. , Figge A. , Poliak S. , Dumuis A. , Peles E. , Bockaert J. , Luebbert H. , Ullmer C.
      J. Biol. Chem.276:12974-12982(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTR2A; HTR2B AND HTR2C;DOMAIN;FUNCTION
    11. 11.
      "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo."
      Kimber W.A. , Trinkle-Mulcahy L. , Cheung P.C.F. , Deak M. , Marsden L.J. , Kieloch A. , Watt S. , Javier R.T. , Gray A. , Downes C.P. , Lucocq J.M. , Alessi D.R.
      Biochem. J.361:525-536(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLEKHA1 AND PLEKHA2;DOMAIN
    12. 12.
      "The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction."
      Coyne C.B. , Voelker T. , Pichla S.L. , Bergelson J.M.
      J. Biol. Chem.279:48079-48084(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CXADR;SUBCELLULAR LOCATION
    13. 13.
      "Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure."
      van de Pavert S.A. , Kantardzhieva A. , Malysheva A. , Meuleman J. , Versteeg I. , Levelt C. , Klooster J. , Geiger S. , Seeliger M.W. , Rashbass P. , Le Bivic A. , Wijnholds J.
      J. Cell Sci.117:4169-4177(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRB1;SUBCELLULAR LOCATION
    14. 14.
      "SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation."
      Krapivinsky G. , Medina I. , Krapivinsky L. , Gapon S. , Clapham D.E.
      Neuron43:563-574(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYNGAP1; CAMK2A AND CAMK2B;MUTAGENESIS OF 147-GLY--PHE-150;DOMAIN;FUNCTION
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HYC2
    20. 20.
      "Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions."
      Elkins J.M. , Papagrigoriou E. , Berridge G. , Yang X. , Phillips C. , Gileadi C. , Savitsky P. , Doyle D.A.
      Protein Sci.16:683-694(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 117-227;X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 373-463;X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 1148-1243;X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1625-1716;X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1722-1806;X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1859-1951;X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 1983-2070
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