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Index > Protein center > MPP7(Gene name) > Human
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  • MPP7 (Gene name),
  • MAGUK p55 subfamily member 7 (Protein name ),  MPP7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MPP7;
    Protein name:
    MAGUK p55 subfamily member 7;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B and LIN7C. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with DLG1 via its N-terminal L27 domain. Interacts with MPP5 and INADL/PATJ.
    Function:
    Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.
    Subcellular Location:
    Membrane Peripheral membrane protein Cell junction tight junction Cell junction adherens junction
    Protein Attributes:
    Sequence length:
    576
    Sequence:
    50:
    MPALSTGSGS | DTGLYELLAA | LPAQLQPHVD | SQEDLTFLWD | MFGEKSLHSL | 
    100:
    VKIHEKLHYY | EKQSPVPILH | GAAALADDLA | EELQNKPLNS | EIRELLKLLS | 
    150:
    KPNVKALLSV | HDTVAQKNYD | PVLPPMPEDI | DDEEDSVKII | RLVKNREPLG | 
    200:
    ATIKKDEQTG | AIIVARIMRG | GAADRSGLIH | VGDELREVNG | IPVEDKRPEE | 
    250:
    IIQILAQSQG | AITFKIIPGS | KEETPSKEGK | MFIKALFDYN | PNEDKAIPCK | 
    300:
    EAGLSFKKGD | ILQIMSQDDA | TWWQAKHEAD | ANPRAGLIPS | KHFQERRLAL | 
    350:
    RRPEILVQPL | KVSNRKSSGF | RKSFRLSRKD | KKTNKSMYEC | KKSDQYDTAD | 
    400:
    VPTYEEVTPY | RRQTNEKYRL | VVLVGPVGVG | LNELKRKLLI | SDTQHYGVTV | 
    450:
    PHTTRARRSQ | ESDGVEYIFI | SKHLFETDVQ | NNKFIEYGEY | KNNYYGTSID | 
    500:
    SVRSVLAKNK | VCLLDVQPHT | VKHLRTLEFK | PYVIFIKPPS | IERLRETRKN | 
    550:
    AKIISSRDDQ | GAAKPFTEED | FQEMIKSAQI | MESQYGHLFD | KIIINDDLTV | 
    576:
    AFNELKTTFD | KLETETHWVP | VSWLHS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human MAGUK p55 subfamily member 7
    ELISA Kit for Human MAGUK p55 subfamily member 7
    ELISA Kit for Human MAGUK p55 subfamily member 7
    ELISA Kit for Human MAGUK p55 subfamily member 7
    CLIA Kit for Human MAGUK p55 subfamily member 7
    CLIA Kit for Human MAGUK p55 subfamily member 7
    CLIA Kit for Human MAGUK p55 subfamily member 7
    CLIA Kit for Human MAGUK p55 subfamily member 7
    Polyclonal Antibody for Human MAGUK p55 subfamily member 7
    Polyclonal Antibody for Human MAGUK p55 subfamily member 7
    Polyclonal Antibody for Human MAGUK p55 subfamily member 7
    Polyclonal Antibody for Human MAGUK p55 subfamily member 7
    Monoclonal Antibody for Human MAGUK p55 subfamily member 7
    Monoclonal Antibody for Human MAGUK p55 subfamily member 7
    Monoclonal Antibody for Human MAGUK p55 subfamily member 7
    Monoclonal Antibody for Human MAGUK p55 subfamily member 7
    Protein for Human MAGUK p55 subfamily member 7
    Protein for Human MAGUK p55 subfamily member 7
    Protein for Human MAGUK p55 subfamily member 7
    Protein for Human MAGUK p55 subfamily member 7

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ARG-322
      tissue: Hippocampus.
      tissue: Mammary gland.
    2. 2.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-322
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-322
      tissue: Testis.
    5. 5.
      "Identification and characterization of human MPP7 gene and mouse Mpp7 gene in silico."
      Katoh M. , Katoh M.
      Int. J. Mol. Med.13:333-338(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
    6. 6.
      "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells."
      Wells C.D. , Fawcett J.P. , Traweger A. , Yamanaka Y. , Goudreault M. , Elder K. , Kulkarni S. , Gish G. , Virag C. , Lim C. , Colwill K. , Starostine A. , Metalnikov P. , Pawson T.
      Cell125:535-548(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INADL AND MPP5
    7. 7.
      "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions."
      Bohl J. , Brimer N. , Lyons C. , Vande Pol S.B.
      J. Biol. Chem.282:9392-9400(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION;INTERACTION WITH DLG1; LIN7A; LIN7B AND LIN7C
    8. 8.
      "Markedly increased urinary preprohaptoglobin and haptoglobin in passive Heymann nephritis: a differential proteomics approach."
      Ngai H.-H. , Sit W.-H. , Jiang P.-P. , Thongboonkerd V. , Wan J.-M.
      J. Proteome Res.6:3313-3320(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;INDUCTION
    9. 9.
      "The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation."
      Stucke V.M. , Timmerman E. , Vandekerckhove J. , Gevaert K. , Hall A.
      Mol. Biol. Cell18:1744-1755(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH DLG1 AND MPP5;MUTAGENESIS OF LEU-38 AND LEU-95
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Structural basis for tandem L27 domain-mediated polymerization."
      Yang X. , Xie X. , Chen L. , Zhou H. , Wang Z. , Zhao W. , Tian R. , Zhang R. , Tian C. , Long J. , Shen Y.
      FASEB J.24:4806-4815(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 7-120 IN COMPLEX WITH DLG1 AND LIN7C;SUBUNIT
    13. 13.
      "Crystal structure of the PDZ domain of mpp7."
      Structural genomics consortium (SGC)
      Submitted (2010-08) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 135-225
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