Protein name:
Serine/threonine-protein kinase MRCK gamma ;
Alternative:
DMPK-like gamma ;CDC42-binding protein kinase gamma ;Myotonic dystrophy protein kinase-like alpha ;Myotonic dystrophy kinase-related CDC42-binding kinase gamma (MRCK gamma;Myotonic dystrophy protein kinase-like gamma) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42.
Function:
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.
Subcellular Location:
Cytoplasm
Concentrates at the leading edge of cells.
Protein Attributes:
50:
MEQRLRALEQ | LVRGEAGGSP | GLDGLLDLLL | GVHQELSSAP | LRRERNVAQF |
100:
LSWASPFVTK | VKELRLQRDD | FEILKVIGRG | AFGEVAVVRQ | RGSGQIFAMK |
150:
MLHKWEMLKR | AETACFREER | DVLVKGDSRW | VTALHYAFQD | EEYLYLVMDY |
200:
YAGGDLLTLL | SRFEDRLPPE | LAQFYLAEMV | LAIHSLHQLG | YVHRDVKPDN |
250:
ILLDMNGHIR | LADFGSCLRL | NNNGMVDSSV | AVGTPDYISP | EILQAMEEGK |
300:
GHYGPQCDWW | SLGVCAYELL | FGETPFYAES | LVETYGKIMN | HEDHLQFPAD |
350:
VTDVPASAQD | LIRQLLCRQE | ERLGRGGLDD | FRKHPFFEGV | DWERLATSTA |
400:
PYIPELRGPM | DTSNFDVDDD | TLNRPETLPP | SSHGAFSGHH | LPFVGFTYTS |
450:
GSPFDVQSSE | LMAAPEGTPH | CVEQVKVELS | HKCQEPLHGP | LQPQELVRLQ |
500:
KEVQVLQEKL | AETLRDSKAS | LSQTDGLHAR | SPAPNIQLQQ | EKDRLQQELT |
550:
EAQAALRVQD | AELCQAQNRQ | EEFLQRLWEA | QEREAAAASQ | IQALNSQLEE |
600:
AWVVRRELEG | QVTTLSQEVT | RLQGQCKQES | SQAKTVHAAP | ETNGIGSPEG |
650:
QSQEAQLRKE | VAALREQLEH | ACSQGISVGK | EEVLCRLQEE | NQRLSREQER |
700:
LAGELELELQ | SKQRLEGERR | ETESNWEAQI | ADILSWVNDE | KVSRGYLQAL |
750:
ATKMAEELES | LRNVGTQTLP | TRPLDHQWKA | RRLQKMEASA | RLELQSALEA |
800:
EIRAKQSLQE | QLTQVQEAQR | QAERRLQEAE | KQSQALQQEV | AELREELQAR |
850:
GPGDARPSTS | LIPLLSFWNT | EKDSAKDPGN | SGEGPRSGAE | AELRPEGRRS |
900:
LRMGSVFPRV | PAATTTPAEG | PPAKPGSHTL | RPRSFPSPTK | CLRCTSLMLG |
950:
LGRQGLGCDT | CGYFCHSACA | SQAPPCPVPP | ELLRTALGVH | PETGTGTAYE |
1000:
GFLSVPRPSG | VRRGWQRVYA | ALSDSRLLLF | DAPDPRGSLA | SGVLLQALDL |
1050:
RDPQFSATPV | LAPDVIHAQS | KDLPRIFRVT | ASQLTVPPTT | CTVLLLAENE |
1100:
GERERWLQVL | GELQRLLLDA | RPRPRPVYTL | KEAYDNGLPL | LPHALCAAVI |
1150:
DQERLALGTE | EGLFVIHLHS | NDIFQVGDCR | RVQRLAVSSA | AGLLAVLCGR |
1200:
GPSVRLFALD | ELESAEVAGA | KIPESRGCQA | LVAGRILQAR | TPVLCVAVKR |
1250:
QVLCYQLGPG | PGPWQRRIRE | LQAPAPVQSL | GLLGDRLCVG | AAGTFALYPL |
1300:
LNEAAPLALG | TGLVAEELPA | SRGGLGEALG | AVELSLSELL | LLFATAGVYV |
1350:
DSAGRKSRSH | ELLWPAAPTG | WGYTAPYLTV | FSENALDVFD | VRRAEWVQTV |
1400:
PLKKVRPLNP | EGSLFLYGTE | KVRLTYLRNP | LAEKDEFDIP | DLTDNSRRQL |
1450:
FRTKSKRRFF | FRVSDELRQQ | QRREMLKDPF | VRSKFISPPT | NFNHLVHVGP |
1500:
TEGRPNTRDG | TRAQEQKSRG | ARSSGPQRPH | SFSEAFRRPV | STGSDGLPGE |
1550:
TDPLVKRKPW | TSLSSESVSC | PQGSLSPAAS | LIQVSERPRS | LPPDPESESS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Serine/threonine-protein kinase MRCK gamma
ELISA Kit for Mouse Serine/threonine-protein kinase MRCK gamma
CLIA Kit for Mouse Serine/threonine-protein kinase MRCK gamma
CLIA Kit for Mouse Serine/threonine-protein kinase MRCK gamma
Polyclonal Antibody for Mouse Serine/threonine-protein kinase MRCK gamma
Polyclonal Antibody for Mouse Serine/threonine-protein kinase MRCK gamma
Monoclonal Antibody for Mouse Serine/threonine-protein kinase MRCK gamma
Monoclonal Antibody for Mouse Serine/threonine-protein kinase MRCK gamma
Protein for Mouse Serine/threonine-protein kinase MRCK gamma
Protein for Mouse Serine/threonine-protein kinase MRCK gamma
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
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Cherry J.L.
,
DiCuccio M.
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Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 699-1551
strain :
FVB/N .
tissue :
Mammary gland .