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Index > Protein center > Abcc1(Gene name) > Rat
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  • Abcc1 (Gene name),
  • Multidrug resistance-associated protein 1 (Protein name ),  MRP1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Abcc1(Mrp1);
    Protein name:
    Multidrug resistance-associated protein 1;
    Alternative:
    Leukotriene C(4) transporter(LTC4 transporter);ATP-binding cassette sub-family C member 1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1532
    Sequence:
    50:
    MALSSFCSSD | GSDPLWDWNV | TWHTSNPDFT | KCFQNTVLTW | VPCFYLWSCF | 
    100:
    PLYFLYLSRH | DRGYIQMTHL | NKAKTALGFF | LWIICWADLF | YSFWERSQGM | 
    150:
    LLAPVLLVSP | TLLGITMLLA | TFLIQFERRK | GVQSSGIMLT | FWLVALLCAL | 
    200:
    AILRSKIISA | LKKDAQVDMF | RDSAFYLYFT | LVFIQLVLSC | FSDSSPLFSE | 
    250:
    TVRDPNPCPE | SSASFLSRIT | FWWITGMMVQ | GYRQPLKSSD | LWSLNKEDTS | 
    300:
    EEVVPVLVNN | WKKECVKSRK | QPVRIVYAPP | KDPTKPKGSS | QLDVNEEVEA | 
    350:
    LIVKSSHKDR | DPSLFKVLYK | TFGPYFLMSF | LYKALHDLMM | FAGPEILELI | 
    400:
    INFVNDREAP | DWQGYLYTAL | LFVSACLQTL | ALHQYFHICF | VTGMRIKTAV | 
    450:
    VGAVYRKALV | ITNSARKSST | VGEIVNLMSV | DAQRFMDLAT | YINMIWSAPL | 
    500:
    QVTLALYFLW | LNLGPSVLAG | VAVMILMVPF | NAVMAMKTKT | YQVAHMKSKD | 
    550:
    NRIKLMNEIL | NGIKVLKLYA | WELAFQDKVM | NIRQEELKVL | KKSAYLAAVG | 
    600:
    TFTWVCTPFL | VALSTFAVFV | TVDEKNILDA | KKAFVSLALF | NILRFPLNIL | 
    650:
    PMVISSIVQA | SVSLKRLRIF | LSHEELEPDS | IERWSIKDGG | GMNSITVKNA | 
    700:
    TFTWARDEPP | TLNGITFAIP | DGALVAVVGQ | VGCGKSSLLS | ALLAEMDKVE | 
    750:
    GHVTLKGSVA | YVPQQAWIQN | DSLRENILFG | RPLQEHCYKA | VMEACALLPD | 
    800:
    LEILPSGDLT | EIGEKGVNLS | GGQKQRVSLA | RAVYCNSDIY | LLDDPLSAVD | 
    850:
    AHVGKHIFEK | VVGPMGLLKN | KTRILVTHGI | SYLPQVDVII | VMSGGKISEM | 
    900:
    GSYQELLDRD | GAFAEFVRTY | ANTEQDLASE | DDSKNGVSGL | GKESKPVENG | 
    950:
    ILVTDAVGKP | LQRHLSNSSS | HSVVTNQQHS | STAELQKSGV | KEETWKLMEA | 
    1000:
    DKAQTGQVKL | SVYWNYMKAI | GLCISFLSIF | LFLCNHVSAL | ASNYWLSLWT | 
    1050:
    DDRPAVNGTQ | ENRNFRLSVY | GALGILQGVA | VFGYSMAVSI | GGIFASRRLH | 
    1100:
    LDLLQNVLRS | PMSFFERTPS | GNLVNRFSKE | LDTVDSMIPQ | VIKMFMGSLF | 
    1150:
    SVIGAVIIIL | LATPIAAVII | PPLGLVYFFV | QRFYVASSRQ | LKRLESVSRS | 
    1200:
    PVYSHFNETL | LGVSVIRAFE | EQERFIRQSD | LKVDENQKAY | YPSIVANRWL | 
    1250:
    AVRLECVGNC | IVLFAALFAV | ISRHSLSAGL | VGLSVSYSLQ | ITAYLNWLVR | 
    1300:
    MSSEMETNIV | AVERLKEYSE | TEKEASWQIQ | ETAPPSTWPH | SGRVEFRDYC | 
    1350:
    LRYREDLDLV | LKHINVTIEG | GEKVGIVGRT | GAGKSSLTLG | LFRINESAEG | 
    1400:
    EIIIDGINIA | KIGLHNLRFK | ITIIPQDPVL | FSGSLRMNLD | PFSQYSDEEV | 
    1450:
    WMALELAHLK | GFVSALPDKL | NHECAEGGEN | LSVGQRQLVC | LARALLRKTK | 
    1500:
    ILVLDEATAA | VDLETDDLIQ | STIRTQFEDS | TVLTIAHRLN | TIMDYTRVIV | 
    1532:
    LDKGEIRECG | APSELLQQRG | VFYSMAKDAG | LV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Multidrug resistance-associated protein 1
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    ELISA Kit for Rat Multidrug resistance-associated protein 1
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    ELISA Kit for Rat Multidrug resistance-associated protein 1
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    ELISA Kit for Rat Multidrug resistance-associated protein 1
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    ELISA Kit for Rat Multidrug resistance-associated protein 1
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    ELISA Kit for Rat Multidrug resistance-associated protein 1
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    CLIA Kit for Rat Multidrug resistance-associated protein 1
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    CLIA Kit for Rat Multidrug resistance-associated protein 1
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    96T
    CLIA Kit for Rat Multidrug resistance-associated protein 1
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    U1068c
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    96T
    CLIA Kit for Rat Multidrug resistance-associated protein 1
    Cat.:
    U1068b
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    MSDS:
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    96T
    CLIA Kit for Rat Multidrug resistance-associated protein 1
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    96T
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    CLIA Kit for Rat Multidrug resistance-associated protein 1
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    U1068h
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    Polyclonal Antibody for Rat Multidrug resistance-associated protein 1
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    P1068Rb-h
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    40ug/0.2ml
    Polyclonal Antibody for Rat Multidrug resistance-associated protein 1
    Polyclonal Antibody for Rat Multidrug resistance-associated protein 1
    Polyclonal Antibody for Rat Multidrug resistance-associated protein 1
    Polyclonal Antibody for Rat Multidrug resistance-associated protein 1
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    P1068Rb-m
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    Polyclonal Antibody for Rat Multidrug resistance-associated protein 1
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    P1068Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Multidrug resistance-associated protein 1
    Monoclonal Antibody for Rat Multidrug resistance-associated protein 1
    Monoclonal Antibody for Rat Multidrug resistance-associated protein 1
    Monoclonal Antibody for Rat Multidrug resistance-associated protein 1
    Monoclonal Antibody for Rat Multidrug resistance-associated protein 1
    Monoclonal Antibody for Rat Multidrug resistance-associated protein 1
    Protein for Rat Multidrug resistance-associated protein 1
    Protein for Rat Multidrug resistance-associated protein 1
    Protein for Rat Multidrug resistance-associated protein 1
    Protein for Rat Multidrug resistance-associated protein 1
    Protein for Rat Multidrug resistance-associated protein 1
    Protein for Rat Multidrug resistance-associated protein 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of the rat multidrug resistance-associated protein 1."
      Yang Z. , Li C.S.W. , Shen D.D. , Ho R.J.Y.
      AAPS PharmSci4:E15-E15(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: Sprague-Dawley.
      tissue: Brain.
    2. 2.
      "Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1)."
      Nunoya K. , Grant C.E. , Zhang D.-W. , Cole S.P.C. , Deeley R.G.
      Drug Metab. Dispos.31:1016-1026(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;MUTAGENESIS OF LEU-983; GLN-1090; SER-1101; VAL-1106 AND ALA-1243
      strain: Sprague-Dawley.
      tissue: Skeletal muscle.
    3. 3.
      Yabuuchi H. , Takayanagi S. , Ishikawa T.
      Submitted (2002-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: Sprague-Dawley.
      tissue: Spleen.
    4. 4.
      Takayanagi S. , Ishikawa T.
      Submitted (2002-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: Sprague-Dawley.
      tissue: Spleen.
    5. 5.
      "The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress."
      Hirrlinger J. , Koenig J. , Keppler D. , Lindenau J. , Schulz J.B. , Dringen R.
      J. Neurochem.76:627-636(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 711-1532 (ISOFORM 1)
    6. 6.
      "cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats."
      Buechler M. , Koenig J. , Brom M. , Kartenbeck J. , Spring H. , Horie T. , Keppler D.
      J. Biol. Chem.271:15091-15098(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1426-1532 (ISOFORMS 1/2)
    7. 7.
      "Multidrug resistance protein 1-mediated transport of saquinavir by microglia."
      Dallas S. , Ronaldson P.T. , Bendayan M. , Bendayan R.
      NeuroReport15:1183-1186(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
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