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Index > Protein center > GPR50(Gene name) > Human
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  • GPR50 (Gene name),
  • Melatonin-related receptor (Protein name ),  MTR1L_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GPR50;
    Protein name:
    Melatonin-related receptor;
    Alternative:
    H9;G protein-coupled receptor 50;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer, and heterodimer with MTNR1A and MTNR1B.
    Function:
    Does not bind melatonin.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    617
    Sequence:
    50:
    MGPTLAVPTP | YGCIGCKLPQ | PEYPPALIIF | MFCAMVITIV | VDLIGNSMVI | 
    100:
    LAVTKNKKLR | NSGNIFVVSL | SVADMLVAIY | PYPLMLHAMS | IGGWDLSQLQ | 
    150:
    CQMVGFITGL | SVVGSIFNIV | AIAINRYCYI | CHSLQYERIF | SVRNTCIYLV | 
    200:
    ITWIMTVLAV | LPNMYIGTIE | YDPRTYTCIF | NYLNNPVFTV | TIVCIHFVLP | 
    250:
    LLIVGFCYVR | IWTKVLAARD | PAGQNPDNQL | AEVRNFLTMF | VIFLLFAVCW | 
    300:
    CPINVLTVLV | AVSPKEMAGK | IPNWLYLAAY | FIAYFNSCLN | AVIYGLLNEN | 
    350:
    FRREYWTIFH | AMRHPIIFFS | GLISDIREMQ | EARTLARARA | HARDQAREQD | 
    400:
    RAHACPAVEE | TPMNVRNVPL | PGDAAAGHPD | RASGHPKPHS | RSSSAYRKSA | 
    450:
    STHHKSVFSH | SKAASGHLKP | VSGHSKPASG | HPKSATVYPK | PASVHFKADS | 
    500:
    VHFKGDSVHF | KPDSVHFKPA | SSNPKPITGH | HVSAGSHSKS | AFSAATSHPK | 
    550:
    PTTGHIKPAT | SHAEPTTADY | PKPATTSHPK | PTAADNPELS | ASHCPEIPAI | 
    600:
    AHPVSDDSDL | PESASSPAAG | PTKPAASQLE | SDTIADLPDP | TVVTTSTNDY | 
    617:
    HDVVVIDVED | DPDEMAV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    MIM:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Melatonin-related receptor
    ELISA Kit for Human Melatonin-related receptor
    ELISA Kit for Human Melatonin-related receptor
    CLIA Kit for Human Melatonin-related receptor
    CLIA Kit for Human Melatonin-related receptor
    CLIA Kit for Human Melatonin-related receptor
    Polyclonal Antibody for Human Melatonin-related receptor
    Polyclonal Antibody for Human Melatonin-related receptor
    Polyclonal Antibody for Human Melatonin-related receptor
    Monoclonal Antibody for Human Melatonin-related receptor
    Monoclonal Antibody for Human Melatonin-related receptor
    Monoclonal Antibody for Human Melatonin-related receptor
    Protein for Human Melatonin-related receptor
    Protein for Human Melatonin-related receptor
    Protein for Human Melatonin-related receptor

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    Linearity
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    References
    1. 1.
      "Cloning of a melatonin-related receptor from human pituitary."
      Reppert S.M. , Weaver D.R. , Ebisawa T. , Mahle C.D. , Kolakowski L.F. Jr.
      FEBS Lett.386:219-224(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS 502-THR--HIS-505 DEL; ALA-532 AND VAL-606
      tissue: Pituitary.
    2. 2.
      Kaighin V.A. , Martin A.L. , Aronstam R.S.
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS 502-THR--HIS-505 DEL AND ALA-532
      tissue: Pituitary.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS 502-THR--HIS-505 DEL; ALA-532 AND VAL-606
    4. 4.
      "The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization."
      Levoye A. , Dam J. , Ayoub M.A. , Guillaume J.L. , Couturier C. , Delagrange P. , Jockers R.
      EMBO J.25:3012-3023(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    5. 5.
      "Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels."
      Bhattacharyya S. , Luan J. , Challis B. , Keogh J. , Montague C. , Brennand J. , Morten J. , Lowenbeim S. , Jenkins S. , Farooqi I.S. , Wareham N.J. , O'Rahilly S.
      J. Lipid Res.47:761-766(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS 502THR--HIS505 DEL; ALA-528 AND ILE-606
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