Muc4 ELISA Kit for Mouse(Mus musculus) | EIAab.comMuc4 ELISA Kit for Mouse(Mus musculus)

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Muc4 (Gene name),

Mucin-4 (Protein name ), MUC4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Muc4;

Protein name:

Mucin-4(MUC-4);

Alternative:

Pancreatic adenocarcinoma mucin;Ascites sialoglycoprotein(ASGP);Testis mucin;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3.

Function:

May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 "Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

Subcellular Location:

Membrane Single-pass membrane protein Secreted Secreted by proteolytic processing.

Protein Attributes:

Sequence length:

3443

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GAFYGILFGT | LGALLLLGIL | AFMIFHFCGC | SMNKFSYPLD | SEL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8JZM8

UniGene:

Mm.214599

Pfam:

PF03782

SMR:

Q8JZM8

Uniprot:

Q8JZM8

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ELISA Kit for Mouse MUC-4

Cat.:

E1034r

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96T

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ELISA Kit for Mouse MUC-4

Cat.:

E1034m

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96T

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ELISA Kit for Mouse MUC-4

Cat.:

E1034h

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96T

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CLIA Kit for Mouse MUC-4

Cat.:

U1034h

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Packing:

96T

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CLIA Kit for Mouse MUC-4

Cat.:

U1034m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MUC-4

Cat.:

U1034r

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse MUC-4

Cat.:

P1034Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MUC-4

Cat.:

P1034Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MUC-4

Cat.:

P1034Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse MUC-4

Protein for Mouse MUC-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4."
Desseyn J.-L. , Clavereau I. , Laine A.
Eur. J. Biochem.269:3150-3159(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];TISSUE SPECIFICITY
strain: 129/SvJ.
2.

"Identification and structure of a mouse homolog to the human MUC4 gene."
Bartman A.E. , Shekels L.L. , Anway R.E. , Gipson I.K. , Moccia R. , Ho S.B.
Submitted (1999-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-231
strain: CD-1.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3076-3443
strain: FVB/N.
tissue: Colon.
4.

"Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways."
Lee C.G. , Homer R.J. , Cohn L. , Link H. , Jung S. , Craft J.E. , Graham B.S. , Johnson T.R. , Elias J.A.
J. Biol. Chem.277:35466-35474(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3181-3351
5.

"Cloning and expression analysis of mouse ascites sialoglycoprotein-2 (ASGP-2)/Mucin 4 (Muc4)."
DeSouza M.M. , Carson D.D. , Harris M.N. , Julian J.
Submitted (1999-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3343-3443
strain: CF-1.
tissue: Uterine horn luminal epithelium.

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