MUS81 ELISA Kit for Human(Homo sapiens) | EIAab.comMUS81 ELISA Kit for Human(Homo sapiens) | EIAab.com

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MUS81 (Gene name),

Crossover junction endonuclease MUS81 (Protein name ), MUS81_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

MUS81;

Protein name:

Crossover junction endonuclease MUS81;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

May self-associate. Interacts with EME1, EME2 and CHEK2. Interacts with BLM, and this interaction may stimulate the endonuclease activity of MUS81. Interacts with SLX4/BTBD12; this interaction is direct and links the MUS81-EME1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair. Interacts with DCLRE1B/Apollo.

Function:

Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.

Subcellular Location:

Nucleus nucleolus Recruited to foci of DNA damage in S-phase cells.

Protein Attributes:

Sequence length:

551

Sequence:

50:

MAAPVRLGRK | RPLPACPNPL | FVRWLTEWRD | EATRSRRRTR | FVFQKALRSL |

100:

RRYPLPLRSG | KEAKILQHFG | DGLCRMLDER | LQRHRTSGGD | HAPDSPSGEN |

150:

SPAPQGRLAE | VQDSSMPVPA | QPKAGGSGSY | WPARHSGARV | ILLVLYREHL |

200:

NPNGHHFLTK | EELLQRCAQK | SPRVAPGSAR | PWPALRSLLH | RNLVLRTHQP |

250:

ARYSLTPEGL | ELAQKLAESE | GLSLLNVGIG | PKEPPGEETA | VPGAASAELA |

300:

SEAGVQQQPL | ELRPGEYRVL | LCVDIGETRG | GGHRPELLRE | LQRLHVTHTV |

350:

RKLHVGDFVW | VAQETNPRDP | ANPGELVLDH | IVERKRLDDL | CSSIIDGRFR |

400:

EQKFRLKRCG | LERRVYLVEE | HGSVHNLSLP | ESTLLQAVTN | TQVIDGFFVK |

450:

RTADIKESAA | YLALLTRGLQ | RLYQGHTLRS | RPWGTPGNPE | SGAMTSPNPL |

500:

CSLLTFSDFN | AGAIKNKAQS | VREVFARQLM | QVRGVSGEKA | AALVDRYSTP |

550:

ASLLAAYDAC | ATPKEQETLL | STIKCGRLQR | NLGPALSRTL | SQLYCSYGPL |

551:

T

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

KEGG:

STRING:

9606.ENSP00000307853

UniGene:

Pfam:

MIM:

String:

Uniprot:

FOR

ELISA Kit for Human Crossover junction endonuclease MUS81

ELISA Kit for Human Crossover junction endonuclease MUS81

ELISA Kit for Human Crossover junction endonuclease MUS81

CLIA Kit for Human Crossover junction endonuclease MUS81

CLIA Kit for Human Crossover junction endonuclease MUS81

CLIA Kit for Human Crossover junction endonuclease MUS81

Polyclonal Antibody for Human Crossover junction endonuclease MUS81

Polyclonal Antibody for Human Crossover junction endonuclease MUS81

Polyclonal Antibody for Human Crossover junction endonuclease MUS81

Monoclonal Antibody for Human Crossover junction endonuclease MUS81

Monoclonal Antibody for Human Crossover junction endonuclease MUS81

Monoclonal Antibody for Human Crossover junction endonuclease MUS81

Protein for Human Crossover junction endonuclease MUS81

Protein for Human Crossover junction endonuclease MUS81

Protein for Human Crossover junction endonuclease MUS81

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Human Mus81-associated endonuclease cleaves Holliday junctions in vitro."
Chen X.-B. , Melchionna R. , Denis C.-M. , Gaillard P.-H.L. , Blasina A. , Van de Weyer I. , Boddy M.N. , Russell P. , Vialard J. , McGowan C.H.
Mol. Cell8:1117-1127(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS HIS-37 AND PRO-180;FUNCTION;COFACTOR;INTERACTION WITH CHEK2;SUBCELLULAR LOCATION;INDUCTION;MUTAGENESIS OF 306-GLY-ASP-307; 333-GLU-ARG-334 AND 338-ASP-ASP-339
tissue: Cerebellum.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS HIS-37 AND PRO-180
tissue: Brain.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-551;VARIANTS HIS-37 AND PRO-180
4.

"Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities."
Constantinou A. , Chen X.-B. , McGowan C.H. , West S.C.
EMBO J.21:5577-5585(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Identification and characterization of human MUS81-MMS4 structure-specific endonuclease."
Oegruenc M. , Sancar A.
J. Biol. Chem.278:21715-21720(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EME1
6.

"Identification and characterization of the human mus81-eme1 endonuclease."
Ciccia A. , Constantinou A. , West S.C.
J. Biol. Chem.278:25172-25178(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EME1
7.

"Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells."
Gao H. , Chen X.-B. , McGowan C.H.
Mol. Biol. Cell14:4826-4834(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
8.

"RNA interference inhibition of Mus81 reduces mitotic recombination in human cells."
Blais V. , Gao H. , Elwell C.A. , Boddy M.N. , Gaillard P.-H.L. , Russell P. , McGowan C.H.
Mol. Biol. Cell15:552-562(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SELF-ASSOCIATION;INTERACTION WITH EME1;SUBCELLULAR LOCATION;MUTAGENESIS OF 338-ASP-ASP-339
9.

"BLM helicase facilitates Mus81 endonuclease activity in human cells."
Zhang R. , Sengupta S. , Yang Q. , Linke S.P. , Yanaihara N. , Bradsher J. , Blais V. , McGowan C.H. , Harris C.C.
Cancer Res.65:2526-2531(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BLM;SUBCELLULAR LOCATION
10.

"Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM."
Ciccia A. , Ling C. , Coulthard R. , Yan Z. , Xue Y. , Meetei A.R. , Laghmani el H. , Joenje H. , McDonald N. , de Winter J.P. , Wang W. , West S.C.
Mol. Cell25:331-343(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EME1 AND EME2
11.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links."
Bae J.B. , Mukhopadhyay S.S. , Liu L. , Zhang N. , Tan J. , Akhter S. , Liu X. , Shen X. , Li L. , Legerski R.J.
Oncogene27:5045-5056(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCLRE1B
13.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair."
Munoz I.M. , Hain K. , Declais A.-C. , Gardiner M. , Toh G.W. , Sanchez-Pulido L. , Heuckmann J.M. , Toth R. , Macartney T. , Eppink B. , Kanaar R. , Ponting C.P. , Lilley D.M.J. , Rouse J.
Mol. Cell35:116-127(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SLX4
15.

"Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair."
Svendsen J.M. , Smogorzewska A. , Sowa M.E. , O'Connell B.C. , Gygi S.P. , Elledge S.J. , Harper J.W.
Cell138:63-77(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SLX4
16.

"Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases."
Fekairi S. , Scaglione S. , Chahwan C. , Taylor E.R. , Tissier A. , Coulon S. , Dong M.-Q. , Ruse C. , Yates J.R. III , Russell P. , Fuchs R.P. , McGowan C.H. , Gaillard P.-H.L.
Cell138:78-89(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLX4
17.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.

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