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Index > Protein center > Mylip(Gene name) > Rat
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  • Mylip (Gene name),
  • E3 ubiquitin-protein ligase MYLIP (Protein name ),  MYLIP_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mylip;
    Protein name:
    E3 ubiquitin-protein ligase MYLIP;
    Alternative:
    Myosin regulatory light chain interacting protein(MIR);Inducible degrader of the LDL-receptor(Idol);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with myosin regulatory light chain (MRLC) and TMEM4.
    Function:
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    445
    Sequence:
    50:
    MLCYVTRPDA | VLMEVEVEAK | ANGEDCLNQV | CRRLGIIEVD | YFGLQFTGSK | 
    100:
    GESLWLNLRN | RISQQMDGLA | PYRLKLRVKF | FVEPHLILQE | QTRHIFFLHI | 
    150:
    KESLLAGHLQ | CSPEQAVELS | ALLAQTKFGD | YNQNTAQYSY | EDLCEKELSS | 
    200:
    STLNSIVGKH | KELEGISQAS | AEYQVLQIVS | AMENYGIEWH | AVRDSEGQKL | 
    250:
    LIGVGPEGIS | ICKEDFSPIN | RIAYPVVQMA | TQSGKNVYLT | VTKESGNSIV | 
    300:
    LLFKMISTRA | ASGLYRAITE | THAFYRCDTV | TSAVMMQYSR | DLKGHLASLF | 
    350:
    LNENINLGKK | YVFDIKRTSK | EVYDHARRAL | YNAGVVDLVS | RNDQSPPSSP | 
    400:
    LKSSDSSMSC | SSCEGLSCQQ | TRVLQEKLRK | LKEAMLCMVC | CEEEINSTFC | 
    445:
    PCGHTVCCES | CAAQLQSCPV | CRSRVEHVQH | VYLPTHTSLL | NLTVI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat E3 ubiquitin-protein ligase MYLIP
    ELISA Kit for Rat E3 ubiquitin-protein ligase MYLIP
    ELISA Kit for Rat E3 ubiquitin-protein ligase MYLIP
    CLIA Kit for Rat E3 ubiquitin-protein ligase MYLIP
    CLIA Kit for Rat E3 ubiquitin-protein ligase MYLIP
    CLIA Kit for Rat E3 ubiquitin-protein ligase MYLIP
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
    Protein for Rat E3 ubiquitin-protein ligase MYLIP
    Protein for Rat E3 ubiquitin-protein ligase MYLIP
    Protein for Rat E3 ubiquitin-protein ligase MYLIP

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    Precision
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    Linearity
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth."
      Olsson P.-A. , Korhonen L. , Mercer E.A. , Lindholm D.
      J. Biol. Chem.274:36288-36292(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    3. 3.
      "Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6."
      Olsson P.A. , Bornhauser B.C. , Korhonen L. , Lindholm D.
      Biochem. Biophys. Res. Commun.279:879-883(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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