Protein name:
E3 ubiquitin-protein ligase MYLIP ;
Alternative:
Myosin regulatory light chain interacting protein (MIR) ;Inducible degrader of the LDL-receptor (Idol) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with myosin regulatory light chain (MRLC) and TMEM4.
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MLCYVTRPDA | VLMEVEVEAK | ANGEDCLNQV | CRRLGIIEVD | YFGLQFTGSK |
100:
GESLWLNLRN | RISQQMDGLA | PYRLKLRVKF | FVEPHLILQE | QTRHIFFLHI |
150:
KESLLAGHLQ | CSPEQAVELS | ALLAQTKFGD | YNQNTAQYSY | EDLCEKELSS |
200:
STLNSIVGKH | KELEGISQAS | AEYQVLQIVS | AMENYGIEWH | AVRDSEGQKL |
250:
LIGVGPEGIS | ICKEDFSPIN | RIAYPVVQMA | TQSGKNVYLT | VTKESGNSIV |
300:
LLFKMISTRA | ASGLYRAITE | THAFYRCDTV | TSAVMMQYSR | DLKGHLASLF |
350:
LNENINLGKK | YVFDIKRTSK | EVYDHARRAL | YNAGVVDLVS | RNDQSPPSSP |
400:
LKSSDSSMSC | SSCEGLSCQQ | TRVLQEKLRK | LKEAMLCMVC | CEEEINSTFC |
445:
PCGHTVCCES | CAAQLQSCPV | CRSRVEHVQH | VYLPTHTSLL | NLTVI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Rat E3 ubiquitin-protein ligase MYLIP
ELISA Kit for Rat E3 ubiquitin-protein ligase MYLIP
ELISA Kit for Rat E3 ubiquitin-protein ligase MYLIP
CLIA Kit for Rat E3 ubiquitin-protein ligase MYLIP
CLIA Kit for Rat E3 ubiquitin-protein ligase MYLIP
CLIA Kit for Rat E3 ubiquitin-protein ligase MYLIP
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase MYLIP
Protein for Rat E3 ubiquitin-protein ligase MYLIP
Protein for Rat E3 ubiquitin-protein ligase MYLIP
Protein for Rat E3 ubiquitin-protein ligase MYLIP
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY