Protein name:
Myosin-Ic ;
Alternative:
Myosin I beta (MMI-beta;MMIb) ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts with RPS6 and actin. Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and calmodulin. Interacts with POLR1A and POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts (via its IQ motifs) with calmodulin.
Function:
Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.
Subcellular Location:
Isoform 3
Nucleus
nucleolus
Nucleus
nucleoplasm
Nucleus
nuclear pore complex
In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level. Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli.
Protein Attributes:
50:
MALQVELIPT | GEIIRVVHPH | RPCKLALGSD | GVRVTMESAL | TARDRVGVQD |
100:
FVLLENFTSE | AAFIENLRRR | FRENLIYTYI | GPVLVSVNPY | RDLQIYSRQH |
150:
MERYRGVSFY | EVPPHLFAVA | DTVYRALRTE | RRDQAVMISG | ESGAGKTEAT |
200:
KRLLQFYAET | CPAPERGGAV | RDRLLQSNPV | LEAFGNAKTL | RNDNSSRFGK |
250:
YMDVQFDFKG | APVGGHILSY | LLEKSRVVHQ | NHGERNFHIF | YQLLEGGEEE |
300:
TLRRLGLERN | PQSYLYLVKG | QCAKVSSIND | KSDWKVVRKA | LTVIDFTEDE |
350:
VEDLLSIVAS | VLHLGNTHFA | ADEESNAQVT | TENQLKYLTR | LLGVEGSTLR |
400:
EALTHRKIIA | KGEELLSPLN | LEQAAYARDA | LAKAVYSRTF | TWLVAKINRS |
450:
LASKDAESPS | WRSTTVLGLL | DIYGFEVFQH | NSFEQFCINY | CNEKLQQLFI |
500:
ELTLKSEQEE | YEAEGIAWEP | VQYFNNKIIC | DLVEEKFKGI | ISILDEECLR |
550:
PGEATDLTFL | EKLEDTIKQH | PHFLTHKLAD | QRTRKSLDRG | EFRLLHYAGE |
600:
VTYNVTGFLD | KNNDLLFRNL | KETMCSSENP | ILGQCFDRSE | LSDKKRPETV |
650:
ATQFKMSLLE | LVEILKSKEP | AYVRCIKPND | SKQPGRFDEV | LIRHQVKYLG |
700:
LMENLRVRRA | GFAYRRKYEA | FLQRYKSLCP | ETWPTWTGRP | QDGVTVLVRH |
750:
LGYKPEEYKM | GRTKIFIRFP | KTLFATEDAL | EIRRQSLATK | IQATWRGFHC |
800:
RQKFLRVKRS | AICIQSWWRG | TLGRRKAAKR | KWAAQTIRRL | IQGFILRHAP |
850:
RCPENAFFVD | HVRTSFLLNL | RRQLPRNILD | TSWPTPPPAL | REASELLREL |
900:
CRKNMVWKYC | RSISPEWKQQ | LQQKAVASEI | FKGKKDNYPQ | SVPRLFISTR |
950:
LGADEINPRV | LQALGSEPIQ | YAVPVVKYDR | KGYKPRSRQL | LLTPNAVVIV |
1000:
EDAKVKQRIE | YTNLTGISVS | SLSDSLFVLH | VQREDNKQKG | DVVLQSDHVI |
1050:
ETLTKTALSA | DRVNNININQ | GSITFAGGPG | RDGIIDFTPG | SELLITKAKN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
Chicken
Rat
ELISA Kit for Bovine Myosin-Ic
ELISA Kit for Bovine Myosin-Ic
ELISA Kit for Bovine Myosin-Ic
ELISA Kit for Bovine Myosin-Ic
ELISA Kit for Bovine Myosin-Ic
CLIA Kit for Bovine Myosin-Ic
CLIA Kit for Bovine Myosin-Ic
CLIA Kit for Bovine Myosin-Ic
CLIA Kit for Bovine Myosin-Ic
CLIA Kit for Bovine Myosin-Ic
Polyclonal Antibody for Bovine Myosin-Ic
Polyclonal Antibody for Bovine Myosin-Ic
Polyclonal Antibody for Bovine Myosin-Ic
Polyclonal Antibody for Bovine Myosin-Ic
Polyclonal Antibody for Bovine Myosin-Ic
Monoclonal Antibody for Bovine Myosin-Ic
Monoclonal Antibody for Bovine Myosin-Ic
Monoclonal Antibody for Bovine Myosin-Ic
Monoclonal Antibody for Bovine Myosin-Ic
Monoclonal Antibody for Bovine Myosin-Ic
Protein for Bovine Myosin-Ic
Protein for Bovine Myosin-Ic
Protein for Bovine Myosin-Ic
Protein for Bovine Myosin-Ic
Protein for Bovine Myosin-Ic
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH CALM;TISSUE SPECIFICITY
tissue :
Adrenal gland .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
Hereford .
tissue :
Fetal skin .
3.
"NEIBank analysis of cow lens."
Wistow G.
Submitted (2006-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-164 (ISOFORM 3)
tissue :
Lens .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 26-1063 (ISOFORM 1/2);INTERACTION WITH CALM
tissue :
Brain .