Protein name:
Myosin-Ic ;
Alternative:
Myosin I beta (MMI-beta;MMIb) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via its IQ motifs) with calmodulin. Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and calmodulin. Interacts with POLR1A and POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Interacts with RPS6 and actin.
Function:
Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.
Subcellular Location:
Isoform 3
Nucleus
nucleoplasm
Nucleus
nucleolus
Nucleus
nuclear pore complex
Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level.
Protein Attributes:
50:
MALQVELVPT | GEIIRVVHPH | RPCKLALGSD | GVRVTMESAL | TARDRVGVQD |
100:
FVLLENFTSE | AAFIENLRRR | FRENLIYTYI | GPVLVSVNPY | RDLQIYSRQH |
150:
MERYRGVSFY | EVPPHLFAVA | DTVYRALRTE | RRDQAVMISG | ESGAGKTEAT |
200:
KRLLQFYAET | CPAPERGGAV | RDRLLQSNPV | LEAFGNAKTL | RNDNSSRFGK |
250:
YMDVQFDFKG | APVGGHILSY | LLEKSRVVHQ | NHGERNFHIF | YQLLEGGEEE |
300:
TLRRLGLERN | PQSYLYLVKG | QCAKVSSIND | KSDWKVVRKA | LTVIDFTEDE |
350:
VEDLLSIVAS | VLHLGNIHFA | ANEESNAQVT | TENQLKYLTR | LLSVEGSTLR |
400:
EALTHRKIIA | KGEELLSPLN | LEQAAYARDA | LAKAVYSRTF | TWLVGKINRS |
450:
LASKDVESPS | WRSTTVLGLL | DIYGFEVFQH | NSFEQFCINY | CNEKLQQLFI |
500:
ELTLKSEQEE | YEAEGIAWEP | VQYFNNKIIC | DLVEEKFKGI | ISILDEECLR |
550:
PGEATDLTFL | EKLEDTVKHH | PHFLTHKLAD | QRTRKSLGRG | EFRLLHYAGE |
600:
VTYSVTGFLD | KNNDLLFRNL | KETMCSSKNP | IMSQCFDRSE | LSDKKRPETV |
650:
ATQFKMSLLQ | LVEILQSKEP | AYVRCIKPND | AKQPGRFDEV | LIRHQVKYLG |
700:
LLENLRVRRA | GFAYRRKYEA | FLQRYKSLCP | ETWPTWAGRP | QDGVAVLVRH |
750:
LGYKPEEYKM | GRTKIFIRFP | KTLFATEDAL | EVRRQSLATK | IQAAWRGFHW |
800:
RQKFLRVKRS | AICIQSWWRG | TLGRRKAAKR | KWAAQTIRRL | IRGFVLRHAP |
850:
RCPENAFFLD | HVRTSFLLNL | RRQLPQNVLD | TSWPTPPPAL | REASELLREL |
900:
CIKNMVWKYC | RSISPEWKQQ | LQQKAVASEI | FKGKKDNYPQ | SVPRLFISTR |
950:
LGTDEISPRV | LQALGSEPIQ | YAVPVVKYDR | KGYKPRSRQL | LLTPNAVVIV |
1000:
EDAKVKQRID | YANLTGISVS | SLSDSLFVLH | VQRADNKQKG | DVVLQSDHVI |
1050:
ETLTKTALSA | NRVNSININQ | GSITFAGGPG | RDGTIDFTPG | SELLITKAKN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
Chicken
Rat
ELISA Kit for Human Myosin-Ic
ELISA Kit for Human Myosin-Ic
ELISA Kit for Human Myosin-Ic
ELISA Kit for Human Myosin-Ic
ELISA Kit for Human Myosin-Ic
CLIA Kit for Human Myosin-Ic
CLIA Kit for Human Myosin-Ic
CLIA Kit for Human Myosin-Ic
CLIA Kit for Human Myosin-Ic
CLIA Kit for Human Myosin-Ic
Polyclonal Antibody for Human Myosin-Ic
Polyclonal Antibody for Human Myosin-Ic
Polyclonal Antibody for Human Myosin-Ic
Polyclonal Antibody for Human Myosin-Ic
Polyclonal Antibody for Human Myosin-Ic
Monoclonal Antibody for Human Myosin-Ic
Monoclonal Antibody for Human Myosin-Ic
Monoclonal Antibody for Human Myosin-Ic
Monoclonal Antibody for Human Myosin-Ic
Monoclonal Antibody for Human Myosin-Ic
Protein for Human Myosin-Ic
Protein for Human Myosin-Ic
Protein for Human Myosin-Ic
Protein for Human Myosin-Ic
Protein for Human Myosin-Ic
R&D Technical Data
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Precision
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Recovery
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Linearity
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS ILE-795 AND ARG-826
tissue :
Kidney .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ILE-795 AND ARG-826
tissue :
Trachea .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ILE-795 AND ARG-826
4.
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Nature440:1045-1049(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS ILE-795 AND ARG-826
tissue :
Eye .
tissue :
Liver .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-206 (ISOFORM 3)
tissue :
Teratocarcinoma .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 36-43; 92-98; 104-125; 133-146; 172-188; 198-209; 255-269; 341-350; 357-396; 400-412; 562-568; 606-624; 633-643; 648-656; 666-674; 715-734; 814-822; 827-841; 875-884; 886-894; 901-930; 937-956 AND 988-1047;ACETYLATION AT MET-1 (ISOFORM 2);METHYLATION AT LYS-383;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Cervix carcinoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RPS6 AND ACTIN;SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE B-WICH COMPLEX
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
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Cited for : ALTERNATIVE SPLICING (ISOFORM 1);SUBCELLULAR LOCATION (ISOFORM 1)
15.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.74 ANGSTROMS) OF 36-760 (ISOFORM 2) IN COMPLEX WITH ADP ORTHOVANADATE AND CALM;INTERACTION WITH CALM AND YWHAB;FUNCTION;ACTIN-BINDING;FUNCTION IN ACTIN-DEPENDENT ATP HYDROLYSIS;MUTAGENESIS OF SER-736