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Index > Protein center > MYO1C(Gene name) > Human
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  • MYO1C (Gene name),
  • Myosin-Ic (Protein name ),  MYO1C_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MYO1C;
    Protein name:
    Myosin-Ic;
    Alternative:
    Myosin I beta(MMI-beta;MMIb);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via its IQ motifs) with calmodulin. Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and calmodulin. Interacts with POLR1A and POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Interacts with RPS6 and actin.
    Function:
    Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.
    Subcellular Location:
    Isoform 3 Nucleus nucleoplasm Nucleus nucleolus Nucleus nuclear pore complex Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level.
    Protein Attributes:
    Sequence length:
    1063
    Sequence:
    50:
    MALQVELVPT | GEIIRVVHPH | RPCKLALGSD | GVRVTMESAL | TARDRVGVQD | 
    100:
    FVLLENFTSE | AAFIENLRRR | FRENLIYTYI | GPVLVSVNPY | RDLQIYSRQH | 
    150:
    MERYRGVSFY | EVPPHLFAVA | DTVYRALRTE | RRDQAVMISG | ESGAGKTEAT | 
    200:
    KRLLQFYAET | CPAPERGGAV | RDRLLQSNPV | LEAFGNAKTL | RNDNSSRFGK | 
    250:
    YMDVQFDFKG | APVGGHILSY | LLEKSRVVHQ | NHGERNFHIF | YQLLEGGEEE | 
    300:
    TLRRLGLERN | PQSYLYLVKG | QCAKVSSIND | KSDWKVVRKA | LTVIDFTEDE | 
    350:
    VEDLLSIVAS | VLHLGNIHFA | ANEESNAQVT | TENQLKYLTR | LLSVEGSTLR | 
    400:
    EALTHRKIIA | KGEELLSPLN | LEQAAYARDA | LAKAVYSRTF | TWLVGKINRS | 
    450:
    LASKDVESPS | WRSTTVLGLL | DIYGFEVFQH | NSFEQFCINY | CNEKLQQLFI | 
    500:
    ELTLKSEQEE | YEAEGIAWEP | VQYFNNKIIC | DLVEEKFKGI | ISILDEECLR | 
    550:
    PGEATDLTFL | EKLEDTVKHH | PHFLTHKLAD | QRTRKSLGRG | EFRLLHYAGE | 
    600:
    VTYSVTGFLD | KNNDLLFRNL | KETMCSSKNP | IMSQCFDRSE | LSDKKRPETV | 
    650:
    ATQFKMSLLQ | LVEILQSKEP | AYVRCIKPND | AKQPGRFDEV | LIRHQVKYLG | 
    700:
    LLENLRVRRA | GFAYRRKYEA | FLQRYKSLCP | ETWPTWAGRP | QDGVAVLVRH | 
    750:
    LGYKPEEYKM | GRTKIFIRFP | KTLFATEDAL | EVRRQSLATK | IQAAWRGFHW | 
    800:
    RQKFLRVKRS | AICIQSWWRG | TLGRRKAAKR | KWAAQTIRRL | IRGFVLRHAP | 
    850:
    RCPENAFFLD | HVRTSFLLNL | RRQLPQNVLD | TSWPTPPPAL | REASELLREL | 
    900:
    CIKNMVWKYC | RSISPEWKQQ | LQQKAVASEI | FKGKKDNYPQ | SVPRLFISTR | 
    950:
    LGTDEISPRV | LQALGSEPIQ | YAVPVVKYDR | KGYKPRSRQL | LLTPNAVVIV | 
    1000:
    EDAKVKQRID | YANLTGISVS | SLSDSLFVLH | VQRADNKQKG | DVVLQSDHVI | 
    1050:
    ETLTKTALSA | NRVNSININQ | GSITFAGGPG | RDGTIDFTPG | SELLITKAKN | 
    1063:
    GHLAVVAPRL | NSR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Myosin-Ic
    ELISA Kit for Human Myosin-Ic
    ELISA Kit for Human Myosin-Ic
    ELISA Kit for Human Myosin-Ic
    ELISA Kit for Human Myosin-Ic
    CLIA Kit for Human Myosin-Ic
    CLIA Kit for Human Myosin-Ic
    CLIA Kit for Human Myosin-Ic
    CLIA Kit for Human Myosin-Ic
    CLIA Kit for Human Myosin-Ic
    Polyclonal Antibody for Human Myosin-Ic
    Polyclonal Antibody for Human Myosin-Ic
    Polyclonal Antibody for Human Myosin-Ic
    Polyclonal Antibody for Human Myosin-Ic
    Polyclonal Antibody for Human Myosin-Ic
    Monoclonal Antibody for Human Myosin-Ic
    Monoclonal Antibody for Human Myosin-Ic
    Monoclonal Antibody for Human Myosin-Ic
    Monoclonal Antibody for Human Myosin-Ic
    Monoclonal Antibody for Human Myosin-Ic
    Protein for Human Myosin-Ic
    Protein for Human Myosin-Ic
    Protein for Human Myosin-Ic
    Protein for Human Myosin-Ic
    Protein for Human Myosin-Ic

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    References
    1. 1.
      "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins."
      Crozet F. , El-Amraoui A. , Blanchard S. , Lenoir M. , Ripoll C. , Vago P. , Hamel C. , Fizames C. , Levi-Acobas F. , Depetris D. , Mattei M.-G. , Weil D. , Pujol R. , Petit C.
      Genomics40:332-341(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS ILE-795 AND ARG-826
      tissue: Kidney.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ILE-795 AND ARG-826
      tissue: Trachea.
    3. 3.
      "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
      Nakajima D. , Saito K. , Yamakawa H. , Kikuno R.F. , Nakayama M. , Ohara R. , Okazaki N. , Koga H. , Nagase T. , Ohara O.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ILE-795 AND ARG-826
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS ILE-795 AND ARG-826
      tissue: Eye.
      tissue: Liver.
    5. 6.
      Strausberg R.L.
      Submitted (2002-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-206 (ISOFORM 3)
      tissue: Teratocarcinoma.
    6. 7.
      Bienvenut W.V. , Calvo F.
      Submitted (2008-02) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 36-43; 92-98; 104-125; 133-146; 172-188; 198-209; 255-269; 341-350; 357-396; 400-412; 562-568; 606-624; 633-643; 648-656; 666-674; 715-734; 814-822; 827-841; 875-884; 886-894; 901-930; 937-956 AND 988-1047;ACETYLATION AT MET-1 (ISOFORM 2);METHYLATION AT LYS-383;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Cervix carcinoma.
    7. 8.
      "Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell."
      Kysela K. , Philimonenko A.A. , Philimonenko V.V. , Janacek J. , Kahle M. , Hozak P.
      Histochem. Cell Biol.124:347-358(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    8. 9.
      "Small ribosomal subunits associate with nuclear myosin and actin in transit to the nuclear pores."
      Cisterna B. , Necchi D. , Prosperi E. , Biggiogera M.
      FASEB J.20:1901-1903(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RPS6 AND ACTIN;SUBCELLULAR LOCATION
    9. 10.
      "The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription."
      Cavellan E. , Asp P. , Percipalle P. , Oestlund Farrants A.-K.
      J. Biol. Chem.281:16264-16271(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE B-WICH COMPLEX
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 14.
      "Identification and characterization of a novel myosin Ic isoform that localizes to the nucleus."
      Ihnatovych I. , Migocka-Patrzalek M. , Dukh M. , Hofmann W.A.
      Cytoskeleton69:555-565(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 1);SUBCELLULAR LOCATION (ISOFORM 1)
    14. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 16.
      "Crystal structure of human myosin 1c - the motor in GLUT4 exocytosis: implications for Ca(2+)-regulation and 14-3-3 binding."
      Stefan Munnich M.H. , Manstein D.J.
      J. Mol. Biol.426:2070-2081(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.74 ANGSTROMS) OF 36-760 (ISOFORM 2) IN COMPLEX WITH ADP ORTHOVANADATE AND CALM;INTERACTION WITH CALM AND YWHAB;FUNCTION;ACTIN-BINDING;FUNCTION IN ACTIN-DEPENDENT ATP HYDROLYSIS;MUTAGENESIS OF SER-736
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