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Index > Protein center > MYO5B(Gene name) > Human
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  • MYO5B (Gene name),
  • Myosin-Vb (Protein name ),  MYO5B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MYO5B(KIAA1119);
    Protein name:
    Myosin-Vb;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with RAB11FIP2, RAB11A, and RAB8A. Found in a complex with CFTR and RAB11A. Interacts with NPC1L1.
    Function:
    May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1848
    Sequence:
    50:
    MSVGELYSQC | TRVWIPDPDE | VWRSAELTKD | YKEGDKSLQL | RLEDETILEY | 
    100:
    PIDVQRNQLP | FLRNPDILVG | ENDLTALSYL | HEPAVLHNLK | VRFLESNHIY | 
    150:
    TYCGIVLVAI | NPYEQLPIYG | QDVIYTYSGQ | NMGDMDPHIF | AVAEEAYKQM | 
    200:
    ARDEKNQSII | VSGESGAGKT | VSAKYAMRYF | ATVGGSASET | NIEEKVLASS | 
    250:
    PIMEAIGNAK | TTRNDNSSRF | GKYIQIGFDK | RYHIIGANMR | TYLLEKSRVV | 
    300:
    FQADDERNYH | IFYQLCAAAG | LPEFKELALT | SAEDFFYTSQ | GGDTSIEGVD | 
    350:
    DAEDFEKTRQ | AFTLLGVKES | HQMSIFKIIA | SILHLGSVAI | QAERDGDSCS | 
    400:
    ISPQDVYLSN | FCRLLGVEHS | QMEHWLCHRK | LVTTSETYVK | TMSLQQVINA | 
    450:
    RNALAKHIYA | QLFGWIVEHI | NKALHTSLKQ | HSFIGVLDIY | GFETFEVNSF | 
    500:
    EQFCINYANE | KLQQQFNSHV | FKLEQEEYMK | EQIPWTLIDF | YDNQPCIDLI | 
    550:
    EAKLGILDLL | DEECKVPKGT | DQNWAQKLYD | RHSSSQHFQK | PRMSNTAFII | 
    600:
    VHFADKVEYL | SDGFLEKNRD | TVYEEQINIL | KASKFPLVAD | LFHDDKDPVP | 
    650:
    ATTPGKGSSS | KISVRSARPP | MKVSNKEHKK | TVGHQFRTSL | HLLMETLNAT | 
    700:
    TPHYVRCIKP | NDEKLPFHFD | PKRAVQQLRA | CGVLETIRIS | AAGYPSRWAY | 
    750:
    HDFFNRYRVL | VKKRELANTD | KKAICRSVLE | NLIKDPDKFQ | FGRTKIFFRA | 
    800:
    GQVAYLEKLR | ADKFRTATIM | IQKTVRGWLQ | KVKYHRLKGA | TLTLQRYCRG | 
    850:
    HLARRLAEHL | RRIRAAVVLQ | KHYRMQRARQ | AYQRVRRAAV | VIQAFTRAMF | 
    900:
    VRRTYRQVLM | EHKATTIQKH | VRGWMARRHF | QRLRDAAIVI | QCAFRMLKAR | 
    950:
    RELKALRIEA | RSAEHLKRLN | VGMENKVVQL | QRKIDEQNKE | FKTLSEQLSV | 
    1000:
    TTSTYTMEVE | RLKKELVHYQ | QSPGEDTSLR | LQEEVESLRT | ELQRAHSERK | 
    1050:
    ILEDAHSREK | DELRKRVADL | EQENALLKDE | KEQLNNQILC | QSKDEFAQNS | 
    1100:
    VKENLMKKEL | EEERSRYQNL | VKEYSQLEQR | YDNLRDEMTI | IKQTPGHRRN | 
    1150:
    PSNQSSLESD | SNYPSISTSE | IGDTEDALQQ | VEEIGLEKAA | MDMTVFLKLQ | 
    1200:
    KRVRELEQER | KKLQVQLEKR | EQQDSKKVQA | EPPQTDIDLD | PNADLAYNSL | 
    1250:
    KRQELESENK | KLKNDLNELR | KAVADQATQN | NSSHGSPDSY | SLLLNQLKLA | 
    1300:
    HEELEVRKEE | VLILRTQIVS | ADQRRLAGRN | AEPNINARSS | WPNSEKHVDQ | 
    1350:
    EDAIEAYHGV | CQTNSKTEDW | GYLNEDGELG | LAYQGLKQVA | RLLEAQLQAQ | 
    1400:
    SLEHEEEVEH | LKAQLEALKE | EMDKQQQTFC | QTLLLSPEAQ | VEFGVQQEIS | 
    1450:
    RLTNENLDLK | ELVEKLEKNE | RKLKKQLKIY | MKKAQDLEAA | QALAQSERKR | 
    1500:
    HELNRQVTVQ | RKEKDFQGML | EYHKEDEALL | IRNLVTDLKP | QMLSGTVPCL | 
    1550:
    PAYILYMCIR | HADYTNDDLK | VHSLLTSTIN | GIKKVLKKHN | DDFEMTSFWL | 
    1600:
    SNTCRLLHCL | KQYSGDEGFM | TQNTAKQNEH | CLKNFDLTEY | RQVLSDLSIQ | 
    1650:
    IYQQLIKIAE | GVLQPMIVSA | MLENESIQGL | SGVKPTGYRK | RSSSMADGDN | 
    1700:
    SYCLEAIIRQ | MNAFHTVMCD | QGLDPEIILQ | VFKQLFYMIN | AVTLNNLLLR | 
    1750:
    KDVCSWSTGM | QLRYNISQLE | EWLRGRNLHQ | SGAVQTMEPL | IQAAQLLQLK | 
    1800:
    KKTQEDAEAI | CSLCTSLSTQ | QIVKILNLYT | PLNEFEERVT | VAFIRTIQAQ | 
    1848:
    LQERNDPQQL | LLDAKHMFPV | LFPFNPSSLT | MDSIHIPACL | NLEFLNEV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    UniGene:
    String:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Myosin-Vb
    ELISA Kit for Human Myosin-Vb
    ELISA Kit for Human Myosin-Vb
    CLIA Kit for Human Myosin-Vb
    CLIA Kit for Human Myosin-Vb
    CLIA Kit for Human Myosin-Vb
    Polyclonal Antibody for Human Myosin-Vb
    Polyclonal Antibody for Human Myosin-Vb
    Polyclonal Antibody for Human Myosin-Vb
    Monoclonal Antibody for Human Myosin-Vb
    Monoclonal Antibody for Human Myosin-Vb
    Monoclonal Antibody for Human Myosin-Vb
    Protein for Human Myosin-Vb
    Protein for Human Myosin-Vb
    Protein for Human Myosin-Vb

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M. , Nagase T. , Ishikawa K. , Kikuno R. , Nomura N. , Ohara O.
      DNA Res.6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ALA-126 AND LEU-1055 INS
      tissue: Brain.
    2. 2.
      Ohara O. , Nagase T. , Yamakawa H. , Kikuno R.
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO N-TERMINUS AND 918
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Colon.
    4. 4.
      "Multiplex amplification and cloning of 5'-ends of cDNA by ligase-free recombination: preparation of full-length cDNA clones encoding motor proteins."
      Yamakawa H. , Kikuno R.F. , Nagase T. , Ohara O.
      Submitted (2007-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ALA-126 AND LEU-1055 INS
      tissue: Brain.
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Colon.
    6. 7.
      "Identification and characterization of a family of Rab11-interacting proteins."
      Hales C.M. , Griner R. , Hobdy-Henderson K.C. , Dorn M.C. , Hardy D. , Kumar R. , Navarre J. , Chan E.K.L. , Lapierre L.A. , Goldenring J.R.
      J. Biol. Chem.276:39067-39075(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB11FIP2
    7. 8.
      "CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling."
      Yan Q. , Sun W. , Kujala P. , Lotfi Y. , Vida T.A. , Bean A.J.
      Mol. Biol. Cell16:2470-2482(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CART COMPLEX
    8. 9.
      "Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells."
      Swiatecka-Urban A. , Talebian L. , Kanno E. , Moreau-Marquis S. , Coutermarsh B. , Hansen K. , Karlson K.H. , Barnaby R. , Cheney R.E. , Langford G.M. , Fukuda M. , Stanton B.A.
      J. Biol. Chem.282:23725-23736(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAB11A;IDENTIFICATION IN A COMPLEX WITH RAB11A AND CFTR
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 11.
      "Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface."
      Chu B.-B. , Ge L. , Xie C. , Zhao Y. , Miao H.-H. , Wang J. , Li B.-L. , Song B.-L.
      J. Biol. Chem.284:22481-22490(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NPC1L1
    11. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1446;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANTS DIAR2 ARG-316; SER-456; ARG-514 AND LEU-660;VARIANT VAL-1688
    13. 14.
      "Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization."
      Roland J.T. , Bryant D.M. , Datta A. , Itzen A. , Mostov K.E. , Goldenring J.R.
      Proc. Natl. Acad. Sci. U.S.A.108:2789-2794(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAB11A AND RAB8A;MUTAGENESIS OF GLN-1300; TYR-1307; TYR-1714 AND GLN-1748
    14. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 16.
      "Navajo microvillous inclusion disease is due to a mutation in MYO5B."
      Erickson R.P. , Larson-Thome K. , Valenzuela R.K. , Whitaker S.E. , Shub M.D.
      Am. J. Med. Genet. A146A:3117-3119(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DIAR2 LEU-660
    16. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DIAR2 GLY-108; HIS-219 AND CYS-656
    17. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DIAR2 GLU-143; ARG-168; HIS-401; ARG-435 AND ARG-1556
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