Gene name:
MYO5B (KIAA1119) ;
Protein name:
Myosin-Vb ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with RAB11FIP2, RAB11A, and RAB8A. Found in a complex with CFTR and RAB11A. Interacts with NPC1L1.
Function:
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
Subcellular Location:
N/A
Protein Attributes:
50:
MSVGELYSQC | TRVWIPDPDE | VWRSAELTKD | YKEGDKSLQL | RLEDETILEY |
100:
PIDVQRNQLP | FLRNPDILVG | ENDLTALSYL | HEPAVLHNLK | VRFLESNHIY |
150:
TYCGIVLVAI | NPYEQLPIYG | QDVIYTYSGQ | NMGDMDPHIF | AVAEEAYKQM |
200:
ARDEKNQSII | VSGESGAGKT | VSAKYAMRYF | ATVGGSASET | NIEEKVLASS |
250:
PIMEAIGNAK | TTRNDNSSRF | GKYIQIGFDK | RYHIIGANMR | TYLLEKSRVV |
300:
FQADDERNYH | IFYQLCAAAG | LPEFKELALT | SAEDFFYTSQ | GGDTSIEGVD |
350:
DAEDFEKTRQ | AFTLLGVKES | HQMSIFKIIA | SILHLGSVAI | QAERDGDSCS |
400:
ISPQDVYLSN | FCRLLGVEHS | QMEHWLCHRK | LVTTSETYVK | TMSLQQVINA |
450:
RNALAKHIYA | QLFGWIVEHI | NKALHTSLKQ | HSFIGVLDIY | GFETFEVNSF |
500:
EQFCINYANE | KLQQQFNSHV | FKLEQEEYMK | EQIPWTLIDF | YDNQPCIDLI |
550:
EAKLGILDLL | DEECKVPKGT | DQNWAQKLYD | RHSSSQHFQK | PRMSNTAFII |
600:
VHFADKVEYL | SDGFLEKNRD | TVYEEQINIL | KASKFPLVAD | LFHDDKDPVP |
650:
ATTPGKGSSS | KISVRSARPP | MKVSNKEHKK | TVGHQFRTSL | HLLMETLNAT |
700:
TPHYVRCIKP | NDEKLPFHFD | PKRAVQQLRA | CGVLETIRIS | AAGYPSRWAY |
750:
HDFFNRYRVL | VKKRELANTD | KKAICRSVLE | NLIKDPDKFQ | FGRTKIFFRA |
800:
GQVAYLEKLR | ADKFRTATIM | IQKTVRGWLQ | KVKYHRLKGA | TLTLQRYCRG |
850:
HLARRLAEHL | RRIRAAVVLQ | KHYRMQRARQ | AYQRVRRAAV | VIQAFTRAMF |
900:
VRRTYRQVLM | EHKATTIQKH | VRGWMARRHF | QRLRDAAIVI | QCAFRMLKAR |
950:
RELKALRIEA | RSAEHLKRLN | VGMENKVVQL | QRKIDEQNKE | FKTLSEQLSV |
1000:
TTSTYTMEVE | RLKKELVHYQ | QSPGEDTSLR | LQEEVESLRT | ELQRAHSERK |
1050:
ILEDAHSREK | DELRKRVADL | EQENALLKDE | KEQLNNQILC | QSKDEFAQNS |
1100:
VKENLMKKEL | EEERSRYQNL | VKEYSQLEQR | YDNLRDEMTI | IKQTPGHRRN |
1150:
PSNQSSLESD | SNYPSISTSE | IGDTEDALQQ | VEEIGLEKAA | MDMTVFLKLQ |
1200:
KRVRELEQER | KKLQVQLEKR | EQQDSKKVQA | EPPQTDIDLD | PNADLAYNSL |
1250:
KRQELESENK | KLKNDLNELR | KAVADQATQN | NSSHGSPDSY | SLLLNQLKLA |
1300:
HEELEVRKEE | VLILRTQIVS | ADQRRLAGRN | AEPNINARSS | WPNSEKHVDQ |
1350:
EDAIEAYHGV | CQTNSKTEDW | GYLNEDGELG | LAYQGLKQVA | RLLEAQLQAQ |
1400:
SLEHEEEVEH | LKAQLEALKE | EMDKQQQTFC | QTLLLSPEAQ | VEFGVQQEIS |
1450:
RLTNENLDLK | ELVEKLEKNE | RKLKKQLKIY | MKKAQDLEAA | QALAQSERKR |
1500:
HELNRQVTVQ | RKEKDFQGML | EYHKEDEALL | IRNLVTDLKP | QMLSGTVPCL |
1550:
PAYILYMCIR | HADYTNDDLK | VHSLLTSTIN | GIKKVLKKHN | DDFEMTSFWL |
1600:
SNTCRLLHCL | KQYSGDEGFM | TQNTAKQNEH | CLKNFDLTEY | RQVLSDLSIQ |
1650:
IYQQLIKIAE | GVLQPMIVSA | MLENESIQGL | SGVKPTGYRK | RSSSMADGDN |
1700:
SYCLEAIIRQ | MNAFHTVMCD | QGLDPEIILQ | VFKQLFYMIN | AVTLNNLLLR |
1750:
KDVCSWSTGM | QLRYNISQLE | EWLRGRNLHQ | SGAVQTMEPL | IQAAQLLQLK |
1800:
KKTQEDAEAI | CSLCTSLSTQ | QIVKILNLYT | PLNEFEERVT | VAFIRTIQAQ |
1848:
LQERNDPQQL | LLDAKHMFPV | LFPFNPSSLT | MDSIHIPACL | NLEFLNEV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human Myosin-Vb
ELISA Kit for Human Myosin-Vb
ELISA Kit for Human Myosin-Vb
CLIA Kit for Human Myosin-Vb
CLIA Kit for Human Myosin-Vb
CLIA Kit for Human Myosin-Vb
Polyclonal Antibody for Human Myosin-Vb
Polyclonal Antibody for Human Myosin-Vb
Polyclonal Antibody for Human Myosin-Vb
Monoclonal Antibody for Human Myosin-Vb
Monoclonal Antibody for Human Myosin-Vb
Monoclonal Antibody for Human Myosin-Vb
Protein for Human Myosin-Vb
Protein for Human Myosin-Vb
Protein for Human Myosin-Vb
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO N-TERMINUS AND 918
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Colon .
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Submitted (2007-01) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ALA-126 AND LEU-1055 INS
tissue :
Brain .
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"DNA sequence and analysis of human chromosome 18."
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Colon .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RAB11FIP2
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE CART COMPLEX
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH RAB11A;IDENTIFICATION IN A COMPLEX WITH RAB11A AND CFTR
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NPC1L1
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1446;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
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PubMed ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;VARIANTS DIAR2 ARG-316; SER-456; ARG-514 AND LEU-660;VARIANT VAL-1688
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH RAB11A AND RAB8A;MUTAGENESIS OF GLN-1300; TYR-1307; TYR-1714 AND GLN-1748
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PubMed ]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT DIAR2 LEU-660
17.
"MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity."
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Ebner H.L.
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,
Janecke A.R.
more...
Nat. Genet.40:1163-1165(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS DIAR2 GLY-108; HIS-219 AND CYS-656
18.
"Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model."
Ruemmele F.M.
,
Muller T.
,
Schiefermeier N.
,
Ebner H.L.
,
Lechner S.
,
Pfaller K.
,
Thoni C.E.
,
Goulet O.
,
Lacaille F.
,
Schmitz J.
,
Colomb V.
,
Sauvat F.
,
Revillon Y.
,
Canioni D.
,
Brousse N.
,
de Saint-Basile G.
,
Lefebvre J.
,
Heinz-Erian P.
,
Enninger A.
,
Utermann G.
,
Hess M.W.
,
Janecke A.R.
,
Huber L.A.
more...
Hum. Mutat.31:544-551(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS DIAR2 GLU-143; ARG-168; HIS-401; ARG-435 AND ARG-1556