Gene name:
MYO6 (KIAA0389) ;
Protein name:
Myosin-VI ;
Alternative:
Unconventional myosin-6 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal. This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium. Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity). Interacts with DAB2. In vitro, the C-terminal globular tail binds a C-terminal region of DAB2. Interacts with CFTR. Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells. Interacts with OPTN.
Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.
Subcellular Location:
Isoform 4
Cytoplasmic vesicle
clathrin-coated vesicle membrane
Cell projection
ruffle membrane
Protein Attributes:
50:
MEDGKPVWAP | HPTDGFQMGN | IVDIGPDSLT | IEPLNQKGKT | FLALINQVFP |
100:
AEEDSKKDVE | DNCSLMYLNE | ATLLHNIKVR | YSKDRIYTYV | ANILIAVNPY |
150:
FDIPKIYSSE | AIKSYQGKSL | GTRPPHVFAI | ADKAFRDMKV | LKMSQSIIVS |
200:
GESGAGKTEN | TKFVLRYLTE | SYGTGQDIDD | RIVEANPLLE | AFGNAKTVRN |
250:
NNSSRFGKFV | EIHFNEKSSV | VGGFVSHYLL | EKSRICVQGK | EERNYHIFYR |
300:
LCAGASEDIR | EKLHLSSPDN | FRYLNRGCTR | YFANKETDKQ | ILQNRKSPEY |
350:
LKAGSMKDPL | LDDHGDFIRM | CTAMKKIGLD | DEEKLDLFRV | VAGVLHLGNI |
400:
DFEEAGSTSG | GCNLKNKSAQ | SLEYCAELLG | LDQDDLRVSL | TTRVMLTTAG |
450:
GTKGTVIKVP | LKVEQANNAR | DALAKTVYSH | LFDHVVNRVN | QCFPFETSSY |
500:
FIGVLDIAGF | EYFEHNSFEQ | FCINYCNEKL | QQFFNERILK | EEQELYQKEG |
550:
LGVNEVHYVD | NQDCIDLIEA | KLVGILDILD | EENRLPQPSD | QHFTSAVHQK |
600:
HKDHFRLTIP | RKSKLAVHRN | IRDDEGFIIR | HFAGAVCYET | TQFVEKNNDA |
650:
LHMSLESLIC | ESRDKFIREL | FESSTNNNKD | TKQKAGKLSF | ISVGNKFKTQ |
700:
LNLLLDKLRS | TGASFIRCIK | PNLKMTSHHF | EGAQILSQLQ | CSGMVSVLDL |
750:
MQGGYPSRAS | FHELYNMYKK | YMPDKLARLD | PRLFCKALFK | ALGLNENDYK |
800:
FGLTKVFFRP | GKFAEFDQIM | KSDPDHLAEL | VKRVNHWLTC | SRWKKVQWCS |
850:
LSVIKLKNKI | KYRAEACIKM | QKTIRMWLCK | RRHKPRIDGL | VKVGTLKKRL |
900:
DKFNEVVSVL | KDGKPEMNKQ | IKNLEISIDT | LMAKIKSTMM | TQEQIQKEYD |
950:
ALVKSSEELL | SALQKKKQQE | EEAERLRRIQ | EEMEKERKRR | EEDEKRRRKE |
1000:
EEERRMKLEM | EAKRKQEEEE | RKKREDDEKR | IQAEVEAQLA | RQKEEESQQQ |
1050:
AVLEQERRDR | ELALRIAQSE | AELISDEAQA | DLALRRSLDS | YPVSKNDGTR |
1100:
PKMTPEQMAK | EMSEFLSRGP | AVLATKAAAG | TKKYDLSKWK | YAELRDTINT |
1150:
SCDIELLAAC | REEFHRRLKV | YHAWKSKNKK | RNTETEQRAP | KSVTDYDFAP |
1200:
FLNNSPQQNP | AAQIPARQRE | IEMNRQQRFF | RIPFIRPADQ | YKDPQSKKKG |
1250:
WWYAHFDGPW | IARQMELHPD | KPPILLVAGK | DDMEMCELNL | EETGLTRKRG |
1294:
AEILPRQFEE | IWERCGGIQY | LQNAIESRQA | RPTYATAMLQ | SLLK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Pig
Human
Mouse
ELISA Kit for Human Myosin-VI
ELISA Kit for Human Myosin-VI
ELISA Kit for Human Myosin-VI
ELISA Kit for Human Myosin-VI
CLIA Kit for Human Myosin-VI
CLIA Kit for Human Myosin-VI
CLIA Kit for Human Myosin-VI
CLIA Kit for Human Myosin-VI
Polyclonal Antibody for Human Myosin-VI
Polyclonal Antibody for Human Myosin-VI
Polyclonal Antibody for Human Myosin-VI
Polyclonal Antibody for Human Myosin-VI
Monoclonal Antibody for Human Myosin-VI
Monoclonal Antibody for Human Myosin-VI
Monoclonal Antibody for Human Myosin-VI
Monoclonal Antibody for Human Myosin-VI
Protein for Human Myosin-VI
Protein for Human Myosin-VI
Protein for Human Myosin-VI
Protein for Human Myosin-VI
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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tissue :
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 5)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1102-1294 (ISOFORM 6)
tissue :
Salivary gland .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN ENDOCYTOSIS;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CFTR
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT DFNA22 TYR-442
18.
"Mutations of MYO6 are associated with recessive deafness, DFNB37."
Ahmed Z.M.
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Morell R.J.
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Riazuddin S.
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Ahmad M.M.
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Am. J. Hum. Genet.72:1315-1322(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT DFNB37 VAL-216
19.
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Cited for : VARIANT DFNHCM ARG-246