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Index > Protein center > MYO6(Gene name) > Human
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  • MYO6 (Gene name),
  • Myosin-VI (Protein name ),  MYO6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MYO6(KIAA0389);
    Protein name:
    Myosin-VI;
    Alternative:
    Unconventional myosin-6;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal. This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium. Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity). Interacts with DAB2. In vitro, the C-terminal globular tail binds a C-terminal region of DAB2. Interacts with CFTR. Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells. Interacts with OPTN.
    Function:
    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.
    Subcellular Location:
    Isoform 4 Cytoplasmic vesicle clathrin-coated vesicle membrane Cell projection ruffle membrane
    Protein Attributes:
    Sequence length:
    1294
    Sequence:
    50:
    MEDGKPVWAP | HPTDGFQMGN | IVDIGPDSLT | IEPLNQKGKT | FLALINQVFP | 
    100:
    AEEDSKKDVE | DNCSLMYLNE | ATLLHNIKVR | YSKDRIYTYV | ANILIAVNPY | 
    150:
    FDIPKIYSSE | AIKSYQGKSL | GTRPPHVFAI | ADKAFRDMKV | LKMSQSIIVS | 
    200:
    GESGAGKTEN | TKFVLRYLTE | SYGTGQDIDD | RIVEANPLLE | AFGNAKTVRN | 
    250:
    NNSSRFGKFV | EIHFNEKSSV | VGGFVSHYLL | EKSRICVQGK | EERNYHIFYR | 
    300:
    LCAGASEDIR | EKLHLSSPDN | FRYLNRGCTR | YFANKETDKQ | ILQNRKSPEY | 
    350:
    LKAGSMKDPL | LDDHGDFIRM | CTAMKKIGLD | DEEKLDLFRV | VAGVLHLGNI | 
    400:
    DFEEAGSTSG | GCNLKNKSAQ | SLEYCAELLG | LDQDDLRVSL | TTRVMLTTAG | 
    450:
    GTKGTVIKVP | LKVEQANNAR | DALAKTVYSH | LFDHVVNRVN | QCFPFETSSY | 
    500:
    FIGVLDIAGF | EYFEHNSFEQ | FCINYCNEKL | QQFFNERILK | EEQELYQKEG | 
    550:
    LGVNEVHYVD | NQDCIDLIEA | KLVGILDILD | EENRLPQPSD | QHFTSAVHQK | 
    600:
    HKDHFRLTIP | RKSKLAVHRN | IRDDEGFIIR | HFAGAVCYET | TQFVEKNNDA | 
    650:
    LHMSLESLIC | ESRDKFIREL | FESSTNNNKD | TKQKAGKLSF | ISVGNKFKTQ | 
    700:
    LNLLLDKLRS | TGASFIRCIK | PNLKMTSHHF | EGAQILSQLQ | CSGMVSVLDL | 
    750:
    MQGGYPSRAS | FHELYNMYKK | YMPDKLARLD | PRLFCKALFK | ALGLNENDYK | 
    800:
    FGLTKVFFRP | GKFAEFDQIM | KSDPDHLAEL | VKRVNHWLTC | SRWKKVQWCS | 
    850:
    LSVIKLKNKI | KYRAEACIKM | QKTIRMWLCK | RRHKPRIDGL | VKVGTLKKRL | 
    900:
    DKFNEVVSVL | KDGKPEMNKQ | IKNLEISIDT | LMAKIKSTMM | TQEQIQKEYD | 
    950:
    ALVKSSEELL | SALQKKKQQE | EEAERLRRIQ | EEMEKERKRR | EEDEKRRRKE | 
    1000:
    EEERRMKLEM | EAKRKQEEEE | RKKREDDEKR | IQAEVEAQLA | RQKEEESQQQ | 
    1050:
    AVLEQERRDR | ELALRIAQSE | AELISDEAQA | DLALRRSLDS | YPVSKNDGTR | 
    1100:
    PKMTPEQMAK | EMSEFLSRGP | AVLATKAAAG | TKKYDLSKWK | YAELRDTINT | 
    1150:
    SCDIELLAAC | REEFHRRLKV | YHAWKSKNKK | RNTETEQRAP | KSVTDYDFAP | 
    1200:
    FLNNSPQQNP | AAQIPARQRE | IEMNRQQRFF | RIPFIRPADQ | YKDPQSKKKG | 
    1250:
    WWYAHFDGPW | IARQMELHPD | KPPILLVAGK | DDMEMCELNL | EETGLTRKRG | 
    1294:
    AEILPRQFEE | IWERCGGIQY | LQNAIESRQA | RPTYATAMLQ | SLLK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Myosin-VI
    ELISA Kit for Human Myosin-VI
    ELISA Kit for Human Myosin-VI
    ELISA Kit for Human Myosin-VI
    CLIA Kit for Human Myosin-VI
    CLIA Kit for Human Myosin-VI
    CLIA Kit for Human Myosin-VI
    CLIA Kit for Human Myosin-VI
    Polyclonal Antibody for Human Myosin-VI
    Polyclonal Antibody for Human Myosin-VI
    Polyclonal Antibody for Human Myosin-VI
    Polyclonal Antibody for Human Myosin-VI
    Monoclonal Antibody for Human Myosin-VI
    Monoclonal Antibody for Human Myosin-VI
    Monoclonal Antibody for Human Myosin-VI
    Monoclonal Antibody for Human Myosin-VI
    Protein for Human Myosin-VI
    Protein for Human Myosin-VI
    Protein for Human Myosin-VI
    Protein for Human Myosin-VI

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    References
    1. 1.
      "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice."
      Avraham K.B. , Hasson T. , Sobe T. , Balsara B. , Testa J.R. , Skvorak A.B. , Morton C.C. , Copeland N.G. , Jenkins N.A.
      Hum. Mol. Genet.6:1225-1231(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      Avraham K.B.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Genomic organization of the human myosin VI gene (MYO6), a candidate gene for neurosensory and storage disorders."
      Kuehn M.H. , Hageman G.S.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Nakajima D. , Ohira M. , Seki N. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 5)
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes."
      Kimura K. , Wakamatsu A. , Suzuki Y. , Ota T. , Nishikawa T. , Yamashita R. , Yamamoto J. , Sekine M. , Tsuritani K. , Wakaguri H. , Ishii S. , Sugiyama T. , Saito K. , Isono Y. , Irie R. , Kushida N. , Yoneyama T. , Otsuka R. , more...
      Genome Res.16:55-65(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1102-1294 (ISOFORM 6)
      tissue: Salivary gland.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis."
      Buss F. , Arden S.D. , Lindsay M. , Luzio J.P. , Kendrick-Jones J.
      EMBO J.20:3676-3684(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENDOCYTOSIS;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING
    11. 11.
      "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton."
      Morris S.M. , Arden S.D. , Roberts R.C. , Kendrick-Jones J. , Cooper J.A. , Luzio J.P. , Buss F.
      Traffic3:331-341(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
    12. 12.
      "Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator."
      Swiatecka-Urban A. , Boyd C. , Coutermarsh B. , Karlson K.H. , Barnaby R. , Aschenbrenner L. , Langford G.M. , Hasson T. , Stanton B.A.
      J. Biol. Chem.279:38025-38031(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CFTR
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    14. 14.
      "Nuclear myosin VI enhances RNA polymerase II-dependent transcription."
      Vreugde S. , Ferrai C. , Miluzio A. , Hauben E. , Marchisio P.C. , Crippa M.P. , Bussi M. , Biffo S.
      Mol. Cell23:749-755(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      "Myosin VI is a mediator of the p53-dependent cell survival pathway."
      Jung E.J. , Liu G. , Zhou W. , Chen X.
      Mol. Cell. Biol.26:2175-2186(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss."
      Melchionda S. , Ahituv N. , Bisceglia L. , Sobe T. , Glaser F. , Rabionet R. , Arbones M.L. , Notarangelo A. , Di Iorio E. , Carella M. , Zelante L. , Estivill X. , Avraham K.B. , Gasparini P.
      Am. J. Hum. Genet.69:635-640(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DFNA22 TYR-442
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DFNB37 VAL-216
    19. 19.
      "Novel association of hypertrophic cardiomyopathy, sensorineural deafness, and a mutation in unconventional myosin VI (MYO6)."
      Mohiddin S.A. , Ahmed Z.M. , Griffith A.J. , Tripodi D. , Friedman T.B. , Fananapazir L. , Morell R.J.
      J. Med. Genet.41:309-314(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DFNHCM ARG-246
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