MYO6 ELISA Kit for Pig(Sus scrofa) | EIAab.comMYO6 ELISA Kit for Pig(Sus scrofa)

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MYO6 (Gene name),

Myosin-VI (Protein name ), MYO6_PIG from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MYO6;

Protein name:

Myosin-VI;

Alternative:

Unconventional myosin-6;

Organism:

Pig (Sus scrofa).

General Annotation

Sub Unit:

Homodimer. Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal. This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium. Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells. Interacts with DAB2. In vitro, the C-terminal globular tail binds a C-terminal region of DAB2. Interacts with CFTR. Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells. Interacts with OPTN.

Function:

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.

Subcellular Location:

Golgi apparatus trans-Golgi network membrane Peripheral membrane protein Golgi apparatus Nucleus Cytoplasm perinuclear region Also present in endocyctic vesicles, and membrane ruffles. Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage. Recruited into membrane ruffles from cell surface by EGF-stimulation. Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane.

Protein Attributes:

Sequence length:

1254

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1250:

1254:

NLLK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Ssc.94

SMR:

Q29122

String:

Q29122

KEGG:

ssc:397085

Pfam:

PF00063

Uniprot:

Q29122

FOR

ELISA Kit for Pig Myosin-VI

CLIA Kit for Pig Myosin-VI

Polyclonal Antibody for Pig Myosin-VI

Monoclonal Antibody for Pig Myosin-VI

Protein for Pig Myosin-VI

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Porcine myosin-VI: characterization of a new mammalian unconventional myosin."
Hasson T. , Mooseker M.S.
J. Cell Biol.127:425-440(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INTERACTION WITH ACTN1;SUBCELLULAR LOCATION
tissue: Kidney.
2.

"Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types."
Bement W.M. , Hasson T. , Wirth J.A. , Cheney R.E. , Mooseker M.S.
Proc. Natl. Acad. Sci. U.S.A.91:6549-6553(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Kidney.
3.

Bement W.M. , Hasson T. , Wirth J.A. , Cheney R.E. , Mooseker M.S.
Proc. Natl. Acad. Sci. U.S.A.91:11767-11767(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"Calcium functionally uncouples the heads of myosin VI."
Morris C.A. , Wells A.L. , Yang Z. , Chen L.Q. , Baldacchino C.V. , Sweeney H.L.
J. Biol. Chem.278:23324-23330(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-406;CALCIUM-BINDING;MUTAGENESIS OF THR-406
5.

"The unique insert in myosin VI is a structural calcium-calmodulin binding site."
Bahloul A. , Chevreux G. , Wells A.L. , Martin D. , Nolt J. , Yang Z. , Chen L.-Q. , Potier N. , van Dorsselaer A. , Rosenfeld S. , Houdusse A. , Sweeney H.L.
Proc. Natl. Acad. Sci. U.S.A.101:4787-4792(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CALCIUM-CALMODULIN BINDING SITE
6.

"Myosin VI altered at threonine 406 stabilizes actin filaments in vivo."
Naccache S.N. , Hasson T.
Cell Motil. Cytoskeleton63:633-645(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF THR-406;POSSIBLE FUNCTION;SUBCELLULAR LOCATION
7.

"The structure of the myosin VI motor reveals the mechanism of directionality reversal."
Menetrey J. , Bahloul A. , Wells A.L. , Yengo C.M. , Morris C.A. , Sweeney H.L. , Houdusse A.
Nature435:779-785(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-859 IN COMPLEX WITH CALMODULIN;ATPASE ACTIVITY

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