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Index > Protein center > MYPN(Gene name) > Human
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  • MYPN (Gene name),
  • Myopalladin (Protein name ),  MYPN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MYPN(MYOP);
    Protein name:
    Myopalladin;
    Alternative:
    145 kDa sarcomeric protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TTN/titin, NEB, NEBL, ACTN2 and CARP.
    Function:
    Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
    Subcellular Location:
    Cytoplasm Nucleus Cytoplasm myofibril sarcomere Bound to sarcomere both at the Z-line periphery and in the central I-band region.
    Protein Attributes:
    Sequence length:
    1320
    Sequence:
    50:
    MQDDSIEAST | SISQLLRESY | LAETRHRGNN | ERSRAEPSSN | PCHFGSPSGA | 
    100:
    AEGGGGQDDL | PDLSAFLSQE | ELDESVNLAR | LAINYDPLEK | ADETQARKRL | 
    150:
    SPDQMKHSPN | LSFEPNFCQD | NPRSPTSSKE | SPQEAKRPQY | CSETQSKKVF | 
    200:
    LNKAADFIEE | LSSLFKSHSS | KRIRPRACKN | HKSKLESQNK | VMQENSSSFS | 
    250:
    DLSERRERSS | VPIPIPADTR | DNEVNHALEQ | QEAKRREAEQ | AASEAAGGDT | 
    300:
    TPGSSPSSLY | YEEPLGQPPR | FTQKLRSREV | PEGTRVQLDC | IVVGIPPPQV | 
    350:
    RWYCEGKELE | NSPDIHIVQA | GNLHSLTIAE | AFEEDTGRYS | CFASNIYGTD | 
    400:
    STSAEIYIEG | VSSSDSEGDP | NKEEMNRIQK | PNEVSSPPTT | SAVIPPAVPQ | 
    450:
    AQHLVAQPRV | ATIQQCQSPT | NYLQGLDGKP | IIAAPVFTKM | LQNLSASEGQ | 
    500:
    LVVFECRVKG | APSPKVEWYR | EGTLIEDSPD | FRILQKKPRS | MAEPEEICTL | 
    550:
    VIAEVFAEDS | GCFTCTASNK | YGTVSSIAQL | HVRGNEDLSN | NGSLHSANST | 
    600:
    TNLAAIEPQP | SPPHSEPPSV | EQPPKPKLEG | VLVNHNEPRS | SSRIGLRVHF | 
    650:
    NLPEDDKGSE | ASSEAGVVTT | RQTRPDSFQE | RFNGQATKTP | EPSSPVKEPP | 
    700:
    PVLAKPKLDS | TQLQQLHNQV | LLEQHQLQNP | PPSSPKEFPF | SMTVLNSNAP | 
    750:
    PAVTTSSKQV | KAPSSQTFSL | ARPKYFFPST | NTTAATVAPS | SSPVFTLSST | 
    800:
    PQTIQRTVSK | ESLLVSHPSV | QTKSPGGLSI | QNEPLPPGPT | EPTPPPFTFS | 
    850:
    IPSGNQFQPR | CVSPIPVSPT | SRIQNPVAFL | SSVLPSLPAI | PPTNAMGLPR | 
    900:
    SAPSMPSQGL | AKKNTKSPQP | VNDDNIRETK | NAVIRDLGKK | ITFSDVRPNQ | 
    950:
    QEYKISSFEQ | RLMNEIEFRL | ERTPVDESDD | EIQHDEIPTG | KCIAPIFDKR | 
    1000:
    LKHFRVTEGS | PVTFTCKIVG | IPVPKVYWFK | DGKQISKRNE | HCKMRREGDG | 
    1050:
    TCSLHIESTT | SDDDGNYTIM | AANPQGRISC | SGHLMVQSLP | IRSRLTSAGQ | 
    1100:
    SHRGRSRVQE | RDKEPLQERF | FRPHFLQAPG | DMVAHEGRLC | RLDCKVSGLP | 
    1150:
    PPELTWLLNG | QPVLPDASHK | MLVRETGVHS | LLIDPLTQRD | AGTYKCIATN | 
    1200:
    KTGQNSFSLE | LSVVAKEVKK | APVILEKLQN | CGVPEGHPVR | LECRVIGMPP | 
    1250:
    PVFYWKKDNE | TIPCTRERIS | MHQDTTGYAC | LLIQPAKKSD | AGWYTLSAKN | 
    1300:
    EAGIVSCTAR | LDIYAQWHHQ | IPPPMSVRPS | GSRYGSLTSK | GLDIFSAFSS | 
    1320:
    MESTMVYSCS | SRSVVESDEL | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Myopalladin
    ELISA Kit for Human Myopalladin
    CLIA Kit for Human Myopalladin
    CLIA Kit for Human Myopalladin
    Polyclonal Antibody for Human Myopalladin
    Polyclonal Antibody for Human Myopalladin
    Monoclonal Antibody for Human Myopalladin
    Monoclonal Antibody for Human Myopalladin
    Protein for Human Myopalladin
    Protein for Human Myopalladin

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies."
      Bang M.-L. , Mudry R.E. , McElhinny A.S. , Trombitas K. , Geach A.J. , Yamasaki R. , Sorimachi H. , Granzier H. , Gregorio C.C. , Labeit S.
      J. Cell Biol.153:413-427(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH NEB; NEBL; ACTN2 AND CARP;VARIANTS ASN-691; ASN-707 AND ARG-803
      tissue: Skeletal muscle.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Embryo.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Skeletal muscle.
    4. 4.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin."
      Ma K. , Wang K.
      FEBS Lett.532:273-278(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TTN
    6. 6.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-928;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-251; SER-759; SER-813; SER-818 AND SER-928;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101; SER-813 AND SER-928;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RCM4;VARIANTS CHM22 CYS-20; ARG-153; GLU-217; ALA-410; THR-841; LEU-1112; ILE-1161 AND PRO-1265;VARIANTS CMD1KK CYS-20; VAL-213; PHE-339; THR-611; THR-882 AND LEU-954;VARIANTS ALA-393; LYS-467; LYS-614; LEU-628; ASN-691; ASN-707; ARG-803; ARG-804; GLN-955; THR-1135 AND GLY-1306;CHARACTERIZATION OF VARIANT CHM22 CYS-20
    11. 11.
      "Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy."
      Duboscq-Bidot L. , Xu P. , Charron P. , Neyroud N. , Dilanian G. , Millaire A. , Bors V. , Komajda M. , Villard E.
      Cardiovasc. Res.77:118-125(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMD1KK HIS-1088; LEU-1112 AND MET-1195;CHARACTERIZATION OF VARIANTS CMD1KK LEU-1112 AND MET-1195
    12. 12.
      "Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy."
      German Competence Network Heart Failure , Meyer T. , Ruppert V. , Ackermann S. , Richter A. , Perrot A. , Sperling S.R. , Posch M.G. , Maisch B. , Pankuweit S.
      Eur. J. Hum. Genet.21:294-300(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMD1KK TRP-955 AND LEU-961;VARIANTS ALA-393; LEU-628; ASN-691; ASN-707; ARG-803 AND THR-1135
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