Cytoplasmic protein NCK1 (Protein name
), NCK1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
NCK1(NCK);
Protein name:
Cytoplasmic protein NCK1;
Alternative:
SH2/SH3 adaptor protein NCK-alpha;NCK adaptor protein 1(Nck-1);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with SOCS7. This interaction is required for nuclear import. Part of a complex containing PPP1R15B, PP1 and NCK1. Interacts with RALGPS1. Interacts with CAV2 (tyrosine phosphorylated form). Interacts with ADAM15. Interacts with FASLG. Directly interacts with RASA1. Interacts with isoform 4 of MINK1. Interacts (via SH2 domain) with EPHB1; activates the JUN cascade to regulate cell adhesion.
Function:
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2.
Subcellular Location:
Cytoplasm
Endoplasmic reticulum
Nucleus
Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: PHOSPHORYLATION;PARTIAL PROTEIN SEQUENCE
7.
"The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment." Meisenhelder J.
,
Hunter T.
Mol. Cell. Biol.12:5843-5856(1992)
[PubMed]
[Europe PMC]
[Abstract]
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Cited for: PHOSPHORYLATION
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Cited for: FUNCTION IN CELL ADHESION;INTERACTION WITH EPHB1
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Cited for: FUNCTION;INTERACTION WITH EGFR; PAK1; PKN2 AND SOS1;PHOSPHORYLATION
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION IN COMPLEX WITH PP1 AND PPP1R15B;FUNCTION;SUBCELLULAR LOCATION
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SOCS7
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Cited for: FUNCTION;INTERACTION WITH EIF2AK2;PHOSPHORYLATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-105;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-91 AND SER-96;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85 AND TYR-105;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-105;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: INTERACTION WITH RASA1;MUTAGENESIS OF TRP-38; TRP-143; TRP-229 AND ARG-308
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN CELL MIGRATION;INTERACTION WITH EPHA2
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Cited for: STRUCTURE BY NMR OF 1-61 AND 107-165;INTERACTION WITH EGFR
Vaild Sequence:
