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Index > Protein center > NEURL1(Gene name) > Human
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  • NEURL1 (Gene name),
  • E3 ubiquitin-protein ligase NEURL1 (Protein name ),  NEUL1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    NEURL1(NEURL;NEURL1A;RNF67);
    Protein name:
    E3 ubiquitin-protein ligase NEURL1;
    Alternative:
    RING finger protein 67;Neuralized-like protein 1A(h-neu);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CPEB3 (via N-terminus domain); the interaction increases CPEB3 ubiquitination.
    Function:
    Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
    Subcellular Location:
    Cytoplasm Perinuclear region Cell membrane Peripheral membrane protein Perikaryon Cell projection Dendrite Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface.
    Protein Attributes:
    Sequence length:
    574
    Sequence:
    50:
    MGNNFSSIPS | LPRGNPSRAP | RGHPQNLKDS | IGGPFPVTSH | RCHHKQKHCP | 
    100:
    AVLPSGGLPA | TPLLFHPHTK | GSQILMDLSH | KAVKRQASFC | NAITFSNRPV | 
    150:
    LIYEQVRLKI | TKKQCCWSGA | LRLGFTSKDP | SRIHPDSLPK | YACPDLVSQS | 
    200:
    GFWAKALPEE | FANEGNIIAF | WVDKKGRVFH | RINDSAVMLF | FSGVRTADPL | 
    250:
    WALVDVYGLT | RGVQLLDSEL | VLPDCLRPRS | FTALRRPSLR | READDARLSV | 
    300:
    SLCDLNVPGA | DGDEAAPAAG | CPIPQNSLNS | QHSRALPAQL | DGDLRFHALR | 
    350:
    AGAHVRILDE | QTVARVEHGR | DERALVFTSR | PVRVAETIFV | KVTRSGGARP | 
    400:
    GALSFGVTTC | DPGTLRPADL | PFSPEALVDR | KEFWAVCRVP | GPLHSGDILG | 
    450:
    LVVNADGELH | LSHNGAAAGM | QLCVDASQPL | WMLFGLHGTI | TQIRILGSTI | 
    500:
    LAERGIPSLP | CSPASTPTSP | SALGSRLSDP | LLSTCSSGPL | GSSAGGTAPN | 
    550:
    SPVSLPESPV | TPGLGQWSDE | CTICYEHAVD | TVIYTCGHMC | LCYACGLRLK | 
    574:
    KALHACCPIC | RRPIKDIIKT | YRSS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    MIM:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase NEURL1
    ELISA Kit for Human E3 ubiquitin-protein ligase NEURL1
    CLIA Kit for Human E3 ubiquitin-protein ligase NEURL1
    CLIA Kit for Human E3 ubiquitin-protein ligase NEURL1
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase NEURL1
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase NEURL1
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase NEURL1
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase NEURL1
    Protein for Human E3 ubiquitin-protein ligase NEURL1
    Protein for Human E3 ubiquitin-protein ligase NEURL1

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    Linearity
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    References
    1. 1.
      "Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region."
      Nakamura H. , Yoshida M. , Tsuiki H. , Ito K. , Ueno M. , Nakao M. , Oka K. , Tada M. , Kochi M. , Kuratsu J. , Ushio Y. , Saya H.
      Oncogene16:1009-1019(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Fetal brain.
    2. 2.
      Prinos P. , Kilpatrick M.W. , Tsipouras P.
      Submitted (1997-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland."
      Vollrath B. , Pudney J. , Asa S. , Leder P. , Fitzgerald K.
      Mol. Cell. Biol.21:7481-7494(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    6. 6.
      "Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma."
      Teider N. , Scott D.K. , Neiss A. , Weeraratne S.D. , Amani V.M. , Wang Y. , Marquez V.E. , Cho Y.J. , Pomeroy S.L.
      J. Neurooncol.12:1244-1256(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
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