Gene name:
NEURL1 (NEURL;NEURL1A;RNF67) ;
Protein name:
E3 ubiquitin-protein ligase NEURL1 ;
Alternative:
RING finger protein 67 ;Neuralized-like protein 1A (h-neu) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with CPEB3 (via N-terminus domain); the interaction increases CPEB3 ubiquitination.
Function:
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Subcellular Location:
Cytoplasm
Perinuclear region
Cell membrane
Peripheral membrane protein
Perikaryon
Cell projection
Dendrite
Cell junction
Synapse
Postsynaptic cell membrane
Postsynaptic density
Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface.
Protein Attributes:
50:
MGNNFSSIPS | LPRGNPSRAP | RGHPQNLKDS | IGGPFPVTSH | RCHHKQKHCP |
100:
AVLPSGGLPA | TPLLFHPHTK | GSQILMDLSH | KAVKRQASFC | NAITFSNRPV |
150:
LIYEQVRLKI | TKKQCCWSGA | LRLGFTSKDP | SRIHPDSLPK | YACPDLVSQS |
200:
GFWAKALPEE | FANEGNIIAF | WVDKKGRVFH | RINDSAVMLF | FSGVRTADPL |
250:
WALVDVYGLT | RGVQLLDSEL | VLPDCLRPRS | FTALRRPSLR | READDARLSV |
300:
SLCDLNVPGA | DGDEAAPAAG | CPIPQNSLNS | QHSRALPAQL | DGDLRFHALR |
350:
AGAHVRILDE | QTVARVEHGR | DERALVFTSR | PVRVAETIFV | KVTRSGGARP |
400:
GALSFGVTTC | DPGTLRPADL | PFSPEALVDR | KEFWAVCRVP | GPLHSGDILG |
450:
LVVNADGELH | LSHNGAAAGM | QLCVDASQPL | WMLFGLHGTI | TQIRILGSTI |
500:
LAERGIPSLP | CSPASTPTSP | SALGSRLSDP | LLSTCSSGPL | GSSAGGTAPN |
550:
SPVSLPESPV | TPGLGQWSDE | CTICYEHAVD | TVIYTCGHMC | LCYACGLRLK |
574:
KALHACCPIC | RRPIKDIIKT | YRSS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human E3 ubiquitin-protein ligase NEURL1
ELISA Kit for Human E3 ubiquitin-protein ligase NEURL1
CLIA Kit for Human E3 ubiquitin-protein ligase NEURL1
CLIA Kit for Human E3 ubiquitin-protein ligase NEURL1
Polyclonal Antibody for Human E3 ubiquitin-protein ligase NEURL1
Polyclonal Antibody for Human E3 ubiquitin-protein ligase NEURL1
Monoclonal Antibody for Human E3 ubiquitin-protein ligase NEURL1
Monoclonal Antibody for Human E3 ubiquitin-protein ligase NEURL1
Protein for Human E3 ubiquitin-protein ligase NEURL1
Protein for Human E3 ubiquitin-protein ligase NEURL1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue :
Fetal brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[
PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION