Nfatc1 ELISA Kit for Mouse(Mus musculus) | EIAab.comNfatc1 ELISA Kit for Mouse(Mus musculus)

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Nfatc1 (Gene name),

Nuclear factor of activated T-cells, cytoplasmic 1 (Protein name ), NFAC1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Nfatc1(Nfat2;Nfatc);

Protein name:

Nuclear factor of activated T-cells, cytoplasmic 1(NF-ATc1;NFATc1);

Alternative:

NFAT transcription complex cytosolic component(NF-ATc;NFATc);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers.

Function:

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.

Subcellular Location:

Cytoplasm Nucleus Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Protein Attributes:

Sequence length:

717

Sequence:

50:

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300:

350:

400:

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650:

700:

717:

SVFLTLSSES | ELRGGFY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.329560

SMR:

O88942

Pfam:

PF00554

String:

O88942

Uniprot:

O88942

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ELISA Kit for Mouse NF-ATc1

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E1519h

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96T

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ELISA Kit for Mouse NF-ATc1

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E1519m

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ELISA Kit for Mouse NF-ATc1

Cat.:

E1519b

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96T

ELISA Kit for Mouse NF-ATc1

Cat.:

E1519p

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96T

CLIA Kit for Mouse NF-ATc1

Cat.:

U1519b

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96T

CLIA Kit for Mouse NF-ATc1

Cat.:

U1519m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse NF-ATc1

Cat.:

U1519p

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96T

CLIA Kit for Mouse NF-ATc1

Cat.:

U1519h

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96T

Polyclonal Antibody for Mouse NF-ATc1

Cat.:

P1519Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse NF-ATc1

Cat.:

P1519Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse NF-ATc1

Monoclonal Antibody for Mouse NF-ATc1

Protein for Mouse NF-ATc1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc."
Pan S. , Koyano-Nakagawa N. , Tsuruta L. , Amasaki Y. , Yokota T. , Mori S. , Arai N. , Arai K.
Biochem. Biophys. Res. Commun.240:314-323(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA)
2.

"NF-ATc Isoforms are differentially expressed and regulated in murine T and mast cells."
Sherman M.A. , Powell D.R. , Weiss D.L. , Brown M.A.
J. Immunol.162:2820-2828(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
strain: BALB/c.
tissue: Fetal liver.
tissue: Mast cell.

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