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Index > Protein center > NFU1(Gene name) > Human
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  • NFU1 (Gene name),
  • NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (Protein name ),  NFU1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    NFU1(CGI-33;HIRIP5);
    Protein name:
    NFU1 iron-sulfur cluster scaffold homolog, mitochondrial;
    Alternative:
    HIRA-interacting protein 5;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with HIRA and EPM2A/laforin.
    Function:
    Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins.
    Subcellular Location:
    Mitochondrion Cytoplasm cytosol
    Protein Attributes:
    Sequence length:
    254
    Sequence:
    50:
    MAATARRGWG | AAAVAAGLRR | RFCHMLKNPY | TIKKQPLHQF | VQRPLFPLPA | 
    100:
    AFYHPVRYMF | IQTQDTPNPN | SLKFIPGKPV | LETRTMDFPT | PAAAFRSPLA | 
    150:
    RQLFRIEGVK | SVFFGPDFIT | VTKENEELDW | NLLKPDIYAT | IMDFFASGLP | 
    200:
    LVTEETPSGE | AGSEEDDEVV | AMIKELLDTR | IRPTVQEDGG | DVIYKGFEDG | 
    250:
    IVQLKLQGSC | TSCPSSIITL | KNGIQNMLQF | YIPEVEGVEQ | VMDDESDEKE | 
    254:
    ANSP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    MIM:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Cat.:
    E14779h
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Cat.:
    E14779m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Cat.:
    U14779h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Cat.:
    U14779m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Cat.:
    P14779Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Cat.:
    P14779Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Monoclonal Antibody for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Protein for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Protein for Human NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification of human and mouse HIRA-interacting protein-5 (HIRIP5), two mammalian representatives in a family of phylogenetically conserved proteins with a role in the biogenesis of Fe/S proteins."
      Lorain S. , Lecluse Y. , Scamps C. , Mattei M.-G. , Lipinski M.
      Biochim. Biophys. Acta1517:376-383(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      tissue: Myeloid leukemia cell.
    2. 2.
      "The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain."
      Ganesh S. , Tsurutani N. , Suzuki T. , Ueda K. , Agarwala K.L. , Osada H. , Delgado-Escueta A.V. , Yamakawa K.
      Hum. Mol. Genet.12:2359-2368(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH EPM2A;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;VARIANT LYS-25
      tissue: Brain.
    3. 3.
      "Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster."
      Tong W.-H. , Jameson G.N.L. , Huynh B.H. , Rouault T.A.
      Proc. Natl. Acad. Sci. U.S.A.100:9762-9767(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);FUNCTION;SUBCELLULAR LOCATION
    4. 4.
      "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H. , Chou C.-Y. , Ch'ang L.-Y. , Liu C.-S. , Lin W.-C.
      Genome Res.10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT LYS-25
      tissue: Skeletal muscle.
    6. 6.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cerebellum.
    9. 9.
      "Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes."
      Cameron J.M. , Janer A. , Levandovskiy V. , Mackay N. , Rouault T.A. , Tong W.H. , Ogilvie I. , Shoubridge E.A. , Robinson B.H.
      Am. J. Hum. Genet.89:486-495(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INVOLVEMENT IN MMDS1
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Solution NMR structure of NFU1 iron-sulfur cluster scaffold homolog from Homo sapiens, Northeast structural genomics consortium (NESG) target HR2876B."
      Northeast structural genomics consortium (NESG)
      Submitted (2012-08) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 59-155
    12. 12.
      "A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins."
      Navarro-Sastre A. , Tort F. , Stehling O. , Uzarska M.A. , Arranz J.A. , Del Toro M. , Labayru M.T. , Landa J. , Font A. , Garcia-Villoria J. , Merinero B. , Ugarte M. , Gutierrez-Solana L.G. , Campistol J. , Garcia-Cazorla A. , Vaquerizo J. , Riudor E. , Briones P. , more...
      Am. J. Hum. Genet.89:656-667(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MMDS1 CYS-208
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