Klrk1 ELISA Kit for Mouse(Mus musculus) | EIAab.comKlrk1 ELISA Kit for Mouse(Mus musculus)

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Klrk1 (Gene name),

NKG2-D type II integral membrane protein (Protein name ), NKG2D_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Klrk1(Nkg2d);

Protein name:

NKG2-D type II integral membrane protein;

Alternative:

NK cell receptor D;Killer cell lectin-like receptor subfamily K member 1;NKG2-D-activating NK receptor;

CD:

CD314;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.

Function:

Receptor for RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. Involved in the immune surveillance exerted by T and B lymphocytes.

Subcellular Location:

Membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

232

Sequence:

50:

100:

150:

200:

232:

PKGSCAVYGS | SFKAYTEDCA | NLNTYICMKR | AV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.8217

String:

O54709

Pfam:

PF00059

SMR:

O54709

KEGG:

mmu:27007

Uniprot:

O54709

FOR

ELISA Kit for Mouse NKG2-D type II integral membrane protein

CLIA Kit for Mouse NKG2-D type II integral membrane protein

Polyclonal Antibody for Mouse NKG2-D type II integral membrane protein

Monoclonal Antibody for Mouse NKG2-D type II integral membrane protein

Protein for Mouse NKG2-D type II integral membrane protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells."
Ho E.L. , Heusel J.W. , Brown M.G. , Matsumoto K. , Scalzo A.A. , Yokoyama W.M.
Proc. Natl. Acad. Sci. U.S.A.95:6320-6325(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: C57BL/6.
2.

"Mouse natural killer cell receptors homologous to human CD94 and NKG2-D."
Butcher S. , Cottage A. , Cook G.P.
Submitted (1997-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: C57BL/6J.
tissue: Spleen.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: NMRI.
tissue: Mammary tumor.
4.

"Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells."
Vance R.E. , Tanamachi D.M. , Hanke T. , Raulet D.H.
Eur. J. Immunol.27:3236-3241(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: C57BL/6.
5.

"Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice."
Cerwenka A. , Bakker A.B. , McClanahan T. , Wagner J. , Wu J. , Phillips J.H. , Lanier L.L.
Immunity12:721-727(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOTOXICITY ACTIVATION;FUNCTION AS A RECEPTOR FOR RAET1A; RAET1B; RAET1C; RAET1D AND H60
6.

"Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages."
Diefenbach A. , Jamieson A.M. , Liu S.D. , Shastri N. , Raulet D.H.
Nat. Immunol.1:119-126(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOTOXICITY ACTIVATION;FUNCTION AS A RECEPTOR FOR RAET1B AND H60;TISSUE SPECIFICITY
7.

"Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity."
Diefenbach A. , Jensen E.R. , Jamieson A.M. , Raulet D.H.
Nature413:165-171(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOTOXICITY ACTIVATION;FUNCTION AS A RECEPTOR FOR RAET1B AND H60
8.

"Regulation of cutaneous malignancy by gammadelta T cells."
Girardi M. , Oppenheim D.E. , Steele C.R. , Lewis J.M. , Glusac E. , Filler R. , Hobby P. , Sutton B. , Tigelaar R.E. , Hayday A.C.
Science294:605-609(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOTOXICITY ACTIVATION;FUNCTION AS A RECEPTOR FOR RAET1E;TISSUE SPECIFICITY
9.

"The role of the NKG2D immunoreceptor in immune cell activation and natural killing."
Jamieson A.M. , Diefenbach A. , McMahon C.W. , Xiong N. , Carlyle J.R. , Raulet D.H.
Immunity17:19-29(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOTOXICITY ACTIVATION;INDUCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
10.

"Murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D."
Carayannopoulos L.N. , Naidenko O.V. , Fremont D.H. , Yokoyama W.M.
J. Immunol.169:4079-4083(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR MULT1
11.

"Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?"
Vivier E. , Tomasello E. , Paul P.
Curr. Opin. Immunol.14:306-311(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;ALTERNATIVE SPLICING
12.

"Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D."
Diefenbach A. , Tomasello E. , Lucas M. , Jamieson A.M. , Hsia J.K. , Vivier E. , Raulet D.H.
Nat. Immunol.3:1142-1149(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ALTERNATIVE SPLICING (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;INTERACTION WITH HCST AND TYROBP
13.

"NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation."
Gilfillan S. , Ho E.L. , Cella M. , Yokoyama W.M. , Colonna M.
Nat. Immunol.3:1150-1155(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOTOXICITY ACTIVATION;INTERACTION WITH TYROBP
14.

"Involvement of NKR-P2/NKG2D in DC-mediated killing of tumor targets: indicative of a common, innate, target-recognition paradigm?"
Alli R. , Savithri B. , Das S. , Varalakshmi C. , Rangaraj N. , Khar A.
Eur. J. Immunol.34:1119-1126(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
15.

"NKG2D blockade prevents autoimmune diabetes in NOD mice."
Ogasawara K. , Hamerman J.A. , Ehrlich L.R. , Bour-Jordan H. , Santamaria P. , Bluestone J.A. , Lanier L.L.
Immunity20:757-767(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN AUTOIMMUNE DIABETES;INDUCTION
16.

"A Structural basis for the association of DAP12 with mouse, but not human, NKG2D."
Rosen D.B. , Araki M. , Hamerman J.A. , Chen T. , Yamamura T. , Lanier L.L.
J. Immunol.173:2470-2478(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2);INTERACTION WITH HCST AND TYROBP;SUBCELLULAR LOCATION
17.

"Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts."
Ogasawara K. , Benjamin J. , Takaki R. , Phillips J.H. , Lanier L.L.
Nat. Immunol.6:938-945(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IMMUNITY AND ALLOGRAFT REJECTION;FUNCTION AS A RECEPTOR FOR RAET1E
18.

"NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy."
Guerra N. , Tan Y.X. , Joncker N.T. , Choy A. , Gallardo F. , Xiong N. , Knoblaugh S. , Cado D. , Greenberg N.M. , Greenberg N.R. , Raulet D.H.
Immunity28:571-580(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TUMOR SURVEILLANCE;DISRUPTION PHENOTYPE
19.

"Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice."
Zafirova B. , Mandaric S. , Antulov R. , Krmpotic A. , Jonsson H. , Yokoyama W.M. , Jonjic S. , Polic B.
Immunity31:270-282(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NK CELL DIFFERENTIATION;DISRUPTION PHENOTYPE
20.

"Regulation of immune cell function and differentiation by the NKG2D receptor."
Zafirova B. , Wensveen F.M. , Gulin M. , Polic B.
Cell. Mol. Life Sci.68:3519-3529(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;FUNCTION
21.

"Regulation of ligands for the NKG2D activating receptor."
Raulet D.H. , Gasser S. , Gowen B.G. , Deng W. , Jung H.
Annu. Rev. Immunol.31:413-441(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;FUNCTION AS A RECEPTOR FOR MHC CLASS I-RELATED GLYCOPROTEINS
22.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A."
Wolan D.W. , Teyton L. , Rudolph M.G. , Villmow B. , Bauer S. , Busch D.H. , Wilson I.A.
Nat. Immunol.2:248-254(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 110-232
24.

"Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D."
Li P. , McDermott G. , Strong R.K.
Immunity16:77-86(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 110-232 IN COMPLEX WITH RAET1B

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