Grin1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comGrin1 ELISA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Grin1(Gene name) > Rat

Grin1 (Gene name),

Glutamate [NMDA] receptor subunit zeta-1 (Protein name ), NMDZ1_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Grin1(Nmdar1);

Protein name:

Glutamate [NMDA] receptor subunit zeta-1(GluN1);

Alternative:

N-methyl-D-aspartate receptor subunit NR1(NMD-R1);N-methyl-D-aspartate receptor subunit NR1(NMD-R1);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked (By similarity). Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB. Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity). Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. Interacts with GCOM1.

Function:

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Cell junction synapse postsynaptic cell membrane postsynaptic density Enriched in post-synaptic plasma membrane and post-synaptic densities.

Protein Attributes:

Sequence length:

938

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

938:

STGGGRGALQ | NQKDTVLPRR | AIEREEGQLQ | LCSRHRES

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

Pfam:

PF01094

UniGene:

Rn.9840

KEGG:

rno:24408

String:

P35439

SMR:

P35439

Uniprot:

P35439

FOR

ELISA Kit for Rat GluN1

Cat.:

E0336h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Rat GluN1

Cat.:

E0336r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Rat GluN1

Cat.:

E0336m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Rat GluN1

Cat.:

E0336d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat GluN1

Cat.:

U0336d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat GluN1

Cat.:

U0336m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat GluN1

Cat.:

U0336r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Rat GluN1

Cat.:

U0336h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Rat GluN1

Cat.:

P0336Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat GluN1

Cat.:

P0336Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat GluN1

Cat.:

P0336Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat GluN1

Monoclonal Antibody for Rat GluN1

Protein for Rat GluN1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning and characterization of the rat NMDA receptor."
Moriyoshi K. , Masu M. , Ishii T. , Shigemoto R. , Mizuno N. , Nakanishi S.
Nature354:31-37(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue: Brain.
2.

"Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors."
Nakanishi N. , Axel R. , Shneider N.A.
Proc. Natl. Acad. Sci. U.S.A.89:8552-8556(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor."
Hollmann M. , Boulter J. , Maron C. , Beasley L. , Sullivan J. , Pecht G. , Heinemann S.F.
Neuron10:943-954(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Forebrain.
4.

"Cloning and analysis of the 5' flanking sequence of the rat N-methyl-D-aspartate receptor 1 (NMDAR1) gene."
Bai G. , Kusiak J.W.
Biochim. Biophys. Acta1152:197-200(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-86
strain: Sprague-Dawley.
tissue: Liver.
5.

"Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing."
Sugihara H. , Moriyoshi K. , Ishii T. , Masu M. , Nakanishi S.
Biochem. Biophys. Res. Commun.185:826-832(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
tissue: Brain.
6.

"Combinatorial RNA splicing alters the surface charge on the NMDA receptor."
Anantharam V. , Panchal R. , Wilson A. , Koltchin V.V. , Treistman S.N. , Bayley H.
FEBS Lett.305:27-30(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
tissue: Brain.
7.

"An NMDA receptor signaling complex with protein phosphatase 2A."
Chan S.F. , Sucher N.J.
J. Neurosci.21:7985-7992(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-897;DEPHOSPHORYLATION BY PPP2CB;IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B; GRIN3A AND PPP2CB
8.

"Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors."
Perez-Otano I. , Schulteis C.T. , Contractor A. , Lipton S.A. , Trimmer J.S. , Sucher N.J. , Heinemann S.F.
J. Neurosci.21:1228-1237(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B AND GRIN3A
9.

"Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits."
Al-Hallaq R.A. , Jarabek B.R. , Fu Z. , Vicini S. , Wolfe B.B. , Yasuda R.P.
Mol. Pharmacol.62:1119-1127(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B AND GRIN3A
10.

"Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons."
Sasaki Y.F. , Rothe T. , Premkumar L.S. , Das S. , Cui J. , Talantova M.V. , Wong H.-K. , Gong X. , Chan S.F. , Zhang D. , Nakanishi N. , Sucher N.J. , Lipton S.A.
J. Neurophysiol.87:2052-2063(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B AND GRIN3A
11.

"SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation."
Krapivinsky G. , Medina I. , Krapivinsky L. , Gapon S. , Clapham D.E.
Neuron43:563-574(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MPDZ AND DLG4
12.

"Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms."
Sanchez-Perez A.M. , Felipo V.
Neurochem. Int.47:84-91(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-890
13.

"A novel family of adhesion-like molecules that interacts with the NMDA receptor."
Wang C.Y. , Chang K. , Petralia R.S. , Wang Y.X. , Seabold G.K. , Wenthold R.J.
J. Neurosci.26:2174-2183(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRFN2
14.

"SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses."
Ko J. , Kim S. , Chung H.S. , Kim K. , Han K. , Kim H. , Jun H. , Kaang B.-K. , Kim E.
Neuron50:233-245(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRFN1
15.

"GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity."
Roginski R.S. , Goubaeva F. , Mikami M. , Fried-Cassorla E. , Nair M.R. , Yang J.
NeuroReport19:1721-1726(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYZAP
16.

"Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core."
Furukawa H. , Gouaux E.
EMBO J.22:2873-2885(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 394-800 IN COMPLEXES WITH AGONISTS AND ANTAGONIST
17.

"Subunit arrangement and function in NMDA receptors."
Furukawa H. , Singh S.K. , Mancusso R. , Gouaux E.
Nature438:185-192(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 394-800 IN COMPLEX WITH GRIN2A; GLYCINE AND GLUTAMATE;SUBUNIT
18.

"Mechanism of partial agonist action at the NR1 subunit of NMDA receptors."
Inanobe A. , Furukawa H. , Gouaux E.
Neuron47:71-84(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 394-800 IN COMPLEXES WITH AGONISTS;FUNCTION

Product Feedback Wall

* Email:
*Comments: