Nmnat1 ELISA Kit for Mouse(Mus musculus) | EIAab.comNmnat1 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Nmnat1(Gene name) > Mouse

Nmnat1 (Gene name),

Nicotinamide mononucleotide adenylyltransferase 1 (Protein name ), NMNA1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Nmnat1(D4Cole1e;Nmnat);

Protein name:

Nicotinamide mononucleotide adenylyltransferase 1(NMN adenylyltransferase 1);

Alternative:

2.7.7.18;Nicotinate-nucleotide adenylyltransferase 1(NaMN adenylyltransferase 1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homohexamer. Interacts with ADPRT/PARP1.

Function:

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+) (By similarity). Protects against axonal degeneration following mechanical or toxic insults. Delays axonal degeneration after axotomy. Results in a >10-fold increase in intact neurites 72 hours after injury.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

285

Sequence:

50:

100:

150:

200:

250:

285:

KHELYNTESE | GRNAGVTLAP | LQRNAAEAKH | NHSTL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9EPA7

String:

Q9EPA7

Pfam:

PF01467

KEGG:

mmu:66454

UniGene:

Mm.76062

STRING:

10090.ENSMUSP00000030845

Uniprot:

Q9EPA7

FOR

ELISA Kit for Mouse NMN adenylyltransferase 1

CLIA Kit for Mouse NMN adenylyltransferase 1

Polyclonal Antibody for Mouse NMN adenylyltransferase 1

Monoclonal Antibody for Mouse NMN adenylyltransferase 1

Protein for Mouse NMN adenylyltransferase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse."
Conforti L. , Tarlton A. , Mack T.G.A. , Mi W. , Buckmaster E.A. , Wagner D. , Perry V.H. , Coleman M.P.
Proc. Natl. Acad. Sci. U.S.A.97:11377-11382(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
strain: 129.
strain: C57BL/6J.
strain: C57BL/Ola.
2.

"The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells."
Revollo J.R. , Grimm A.A. , Imai S.
J. Biol. Chem.279:50754-50763(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];BIOPHYSICOCHEMICAL PROPERTIES
strain: BALB/c.
tissue: Liver.
3.

"Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration."
Araki T. , Sasaki Y. , Milbrandt J.
Science305:1010-1013(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TRP-170
4.

"Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy."
Sasaki Y. , Araki T. , Milbrandt J.
J. Neurosci.26:8484-8491(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;MUTAGENESIS OF 125-ARG--LYS-128

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