Notch1 ELISA Kit for Mouse(Mus musculus) | EIAab.comNotch1 ELISA Kit for Mouse(Mus musculus)

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Notch1 (Gene name),

Neurogenic locus notch homolog protein 1 (Protein name ), NOTC1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Notch1(Motch);

Protein name:

Neurogenic locus notch homolog protein 1(Notch 1);

Alternative:

mT14;Motch A;p300;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization.

Function:

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

Subcellular Location:

Notch 1 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.

Protein Attributes:

Sequence length:

2531

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2531:

PHSNISDWSE | GISSPPTTMP | SQITHIPEAF | K

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00023

SMR:

Q01705

UniGene:

Mm.290610

String:

Q01705

KEGG:

mmu:18128

Uniprot:

Q01705

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ELISA Kit for Mouse Notch 1

Cat.:

E0501h

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96T

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ELISA Kit for Mouse Notch 1

Cat.:

E0501r

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96T

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ELISA Kit for Mouse Notch 1

Cat.:

E0501m

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96T

CLIA Kit for Mouse Notch 1

Cat.:

U0501m

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96T

CLIA Kit for Mouse Notch 1

Cat.:

U0501h

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Looking for manual.

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96T

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CLIA Kit for Mouse Notch 1

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U0501r

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96T

Polyclonal Antibody for Mouse Notch 1

Cat.:

P0501Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Notch 1

Cat.:

P0501Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Notch 1

Cat.:

P0501Rb-r

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40ug/0.2ml

Monoclonal Antibody for Mouse Notch 1

Protein for Mouse Notch 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch."
Franco del Amo F. , Gendron-Maguire M. , Swiatek P.J. , Jenkins N.A. , Copeland N.G. , Gridley T.
Genomics15:259-264(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Embryo.
2.

"An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells."
Nye J.S. , Kopan R. , Axel R.
Development120:2421-2430(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: BALB/c.
tissue: Thymus.
3.

"Glycogen synthase kinase-3beta modulates notch signaling and stability."
Foltz D.R. , Santiago M.C. , Berechid B.E. , Nye J.S.
Curr. Biol.12:1006-1011(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: BALB/c.
tissue: Thymus.
4.

"Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas."
Tsuji H. , Ishii-Ohba H. , Ukai H. , Katsube T. , Ogiu T.
Carcinogenesis24:1257-1268(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: CB-17/SCID.
tissue: Thymus.
5.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
6.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
8.

"Expression analysis of a Notch homologue in the mouse embryo."
Reaume A.G. , Conlon R.A. , Zirngibl R. , Yamaguchi T.P. , Rossant J.
Dev. Biol.154:377-387(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 731-1899 (ISOFORM 2);DEVELOPMENTAL STAGE
strain: CD-1.
tissue: Embryo.
9.

"Motch A and Motch B-two mouse Notch homologues coexpressed in a wide variety of tissues."
Lardelli M. , Lendahl U.
Exp. Cell Res.204:364-372(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1161-1547
strain: C57BL/6 X CBA.
tissue: Embryo.
10.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1373-2531
strain: NOD.
11.

"Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development."
Franco del Amo F. , Smith D.E. , Swiatek P.J. , Gendron-Maguire M. , Greenspan R.J. , McMahon A.P. , Gridley T.
Development115:737-744(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1551-1647 (ISOFORM 1);DEVELOPMENTAL STAGE
tissue: Embryo.
12.

"The Notch1 receptor is cleaved constitutively by a furin-like convertase."
Logeat F. , Bessia C. , Brou C. , LeBail O. , Jarriault S. , Seidah N.G. , Israel A.
Proc. Natl. Acad. Sci. U.S.A.95:8108-8112(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1655-1659;CLEAVAGE BY FURIN-LIKE CONVERTASE;MUTAGENESIS OF 1651-ARG--ARG-1654
13.

"Murine leukemia provirus-mediated activation of the Notch1 gene leads to induction of HES-1 in a mouse T lymphoma cell line, DL-3."
Lee J.S. , Ishimoto A. , Yanagawa S.
FEBS Lett.455:276-280(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1659-1673
14.

"Mouse notch: expression in hair follicles correlates with cell fate determination."
Kopan R. , Weintraub H.
J. Cell Biol.121:631-641(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1865-2076;DEVELOPMENTAL STAGE IN HAIR FOLLICLES
15.

"Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways."
Zheng X. , Linke S. , Dias J.M. , Zheng X. , Gradin K. , Wallis T.P. , Hamilton B.R. , Gustafsson M. , Ruas J.L. , Wilkins S. , Bilton R.L. , Brismar K. , Whitelaw M.L. , Pereira T. , Gorman J.J. , Ericson J. , Peet D.J. , Lendahl U. , more...
Proc. Natl. Acad. Sci. U.S.A.105:3368-3373(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1937-1952 AND 1995-2019;FUNCTION;INTERACTION WITH HIF1AN;HYDROXYLATION AT ASN-1945 AND ASN-2012 BY HIF1AN;MUTAGENESIS OF ASN-1945 AND ASN-2012;IDENTIFICATION BY MASS SPECTROMETRY
16.

"Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells."
Messerle M. , Follo M. , Nehls M. , Eggert H. , Boehm T.
Cytokines Cell. Mol. Ther.1:139-143(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1951-2201
17.

"Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis."
Saxena M.T. , Schroeter E.H. , Mumm J.S. , Kopan R.
J. Biol. Chem.276:40268-40273(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;PROTEOLYTIC PROCESSING
18.

"Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members."
Mizutani T. , Taniguchi Y. , Aoki T. , Hashimoto N. , Honjo T.
Proc. Natl. Acad. Sci. U.S.A.98:9026-9031(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
19.

"Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis."
Kishi N. , Tang Z. , Maeda Y. , Hirai A. , Mo R. , Ito M. , Suzuki S. , Nakao K. , Kinoshita T. , Kadesch T. , Hui C.-C. , Artavanis-Tsakonas S. , Okano H. , Matsuno K.
Int. J. Dev. Neurosci.19:21-35(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DTX1 AND DTX2
20.

"Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene."
Wu L. , Kobayashi K. , Sun T. , Gao P. , Liu J. , Nakamura M. , Weisberg E. , Mukhopadhyay N.K. , Griffin J.D.
Gene328:153-165(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAML1
21.

"Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor."
Gupta-Rossi N. , Six E. , LeBail O. , Logeat F. , Chastagner P. , Olry A. , Israel A. , Brou C.
J. Cell Biol.166:73-83(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-1749;ENDOCYTOSIS
22.

"DNER acts as a neuron-specific Notch ligand during Bergmann glial development."
Eiraku M. , Tohgo A. , Ono K. , Kaneko M. , Fujishima K. , Hirano T. , Kengaku M.
Nat. Neurosci.8:873-880(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNER;FUNCTION;TISSUE SPECIFICITY
23.

"AIP4/Itch regulates Notch receptor degradation in the absence of ligand."
Chastagner P. , Israel A. , Brou C.
PLoS ONE3:E2735-E2735(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY ITCH
24.

"The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway."
Gupta-Rossi N. , Ortica S. , Meas-Yedid V. , Heuss S. , Moretti J. , Olivo-Marin J.C. , Israel A.
J. Biol. Chem.286:18720-18730(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AAK1
25.

"O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1."
Rana N.A. , Nita-Lazar A. , Takeuchi H. , Kakuda S. , Luther K.B. , Haltiwanger R.S.
J. Biol. Chem.286:31623-31637(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-65; THR-73; THR-116; SER-146; THR-194; SER-341; SER-378; SER-458; THR-466; SER-496; SER-534; SER-609; SER-647; SER-722; SER-759; THR-767; SER-797; THR-805; SER-951; SER-1027; THR-1035; SER-1065; SER-1189; THR-1197; SER-1273 AND THR-1362;MUTAGENESIS OF SER-65; SER-146; SER-341; SER-378; SER-458; SER-496; SER-534; SER-609; SER-647; SER-722; SER-759; SER-797; SER-951; SER-1027; SER-1065; SER-1189 AND SER-1273
26.

"BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets."
Tiberi L. , van den Ameele J. , Dimidschstein J. , Piccirilli J. , Gall D. , Herpoel A. , Bilheu A. , Bonnefont J. , Iacovino M. , Kyba M. , Bouschet T. , Vanderhaeghen P.
Nat. Neurosci.15:1627-1635(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS NEUROGENESIS REPRESSOR;INTERACTION WITH BCL6
27.

"Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4."
Benner E.J. , Luciano D. , Jo R. , Abdi K. , Paez-Gonzalez P. , Sheng H. , Warner D.S. , Liu C. , Eroglu C. , Kuo C.T.
Nature497:369-373(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH THBS4
28.

"The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold."
Lubman O.Y. , Kopan R. , Waksman G. , Korolev S.
Protein Sci.14:1274-1281(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1971-2104
29.

"Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor."
Coleman M.L. , McDonough M.A. , Hewitson K.S. , Coles C. , Mecinovic J. , Edelmann M. , Cook K.M. , Cockman M.E. , Lancaster D.E. , Kessler B.M. , Oldham N.J. , Ratcliffe P.J. , Schofield C.J.
J. Biol. Chem.282:24027-24038(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1899-2106 IN COMPLEX WITH HIF1AN; IRON AND 2-OXOGLUTARATE;HYDROXYLATION AT ASN-1945 AND ASN-2012;MUTAGENESIS OF ASN-1945 AND ASN-2012;IDENTIFICATION BY MASS SPECTROMETRY

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