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Index > Protein center > NPAS2(Gene name) > Chicken
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  • NPAS2 (Gene name),
  • Neuronal PAS domain-containing protein 2 (Protein name ),  NPAS2_CHICK from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    NPAS2(MOP4);
    Protein name:
    Neuronal PAS domain-containing protein 2(Neuronal PAS2);
    Alternative:
    Member of PAS protein 4(MOP4);
    Organism:
    Chicken (Gallus gallus). 
    General Annotation
    Sub Unit:
    Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1E, and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent transactivation.
    Function:
    BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    815
    Sequence:
    50:
    MDEDEKDRAK | RASRNKSEKK | RRDQFNVLIK | ELSSMLPGNT | RKMDKTTVLE | 
    100:
    KVIGFLQKHN | EVSAQTEISE | IQQDWKPSFL | SNEEFTQLML | EALDGFIIAV | 
    150:
    TTGGSIIYVS | DSITPLLGHL | PCDVLDQNLL | NFLPEQEHSE | IYKMLSSCML | 
    200:
    MTDSASSDCL | KTDNELEFYC | HLLRGSLNPK | EFPTYEYIKF | VGNFRSYSNV | 
    250:
    PNSTCNGFDE | AVPRAYRASP | GKQICFVATV | RLATPQFLKE | MCIVEEPLEE | 
    300:
    FTSRHSLEWK | FLFLDHRAPP | IIGYLPFEVL | GTSGYDYYHI | DDLELLARCH | 
    350:
    EHLMQFGKGK | SCCYRFLTKG | QQWIWLQTHY | YITYHQWNSK | PEFIVCTHMV | 
    400:
    VSYADVRVER | RQEMGLEEVS | SEVVSSALKD | SGSSLDPEQH | FNALDIGASI | 
    450:
    LSASRTPSVS | SRSSPKSSHT | PKSDPASTPT | KLTAEASTPL | QRTSSTQQDL | 
    500:
    SAHRLSQPTA | LQASLPSQPS | CELLPQQLLP | QATLQSQPAP | LAQFSAQFSM | 
    550:
    FQTIKDQLEQ | RTRILQANIR | WQQEELQKIQ | EQLCLVQDSS | VQMFLQQPAV | 
    600:
    SLSFSNIQQP | EPQPLQQRPG | VISQQQLVLS | PQLPGQIASP | QTPSQQVLRE | 
    650:
    ASVISSQGPK | AERSTELTTG | SSRPTRSTAT | LFGPSTSLSR | RGPGPSSGPG | 
    700:
    ASAAGCSHDQ | QLRLLLSQPI | QPMMPTSCNA | RHPSDLSMAG | SQAKYSQNQQ | 
    750:
    MFQSLEVQTS | SSGSPIVLMG | QAVLNQGFAT | TPPSQSSSLP | PMQLQHQQHQ | 
    800:
    QQRYLQVQTP | SSLHNEQTDS | LLLSSYSPQQ | GNMGYHQTQQ | QQQQQQLPRR | 
    815:
    SNSLSESSNL | PQPLR
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Chicken Neuronal PAS2
    Cat.:
    E13384h
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    96T
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    ELISA Kit for Chicken Neuronal PAS2
    Cat.:
    E13384c
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    Packing:
    96T
    ELISA Kit for Chicken Neuronal PAS2
    Cat.:
    E13384m
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    Packing:
    96T
    CLIA Kit for Chicken Neuronal PAS2
    Cat.:
    U13384c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Chicken Neuronal PAS2
    Cat.:
    U13384h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Chicken Neuronal PAS2
    Cat.:
    U13384m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Chicken Neuronal PAS2
    Cat.:
    P13384Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Chicken Neuronal PAS2
    Polyclonal Antibody for Chicken Neuronal PAS2
    Cat.:
    P13384Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Chicken Neuronal PAS2
    Monoclonal Antibody for Chicken Neuronal PAS2
    Monoclonal Antibody for Chicken Neuronal PAS2
    Protein for Chicken Neuronal PAS2
    Protein for Chicken Neuronal PAS2
    Protein for Chicken Neuronal PAS2

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    References
    1. 1.
      Codd V. , Chong N.W.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Pineal gland.
    2. 2.
      "Characterization of the chicken serotonin N-acetyltransferase gene. Activation via clock gene heterodimer/E box interaction."
      Chong N.W. , Bernard M. , Klein D.C.
      J. Biol. Chem.275:32991-32998(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 359-469;TISSUE SPECIFICITY;INDUCTION
      strain: White leghorn.
      tissue: Pineal gland.
    3. 3.
      "CLOCK and NPAS2 have overlapping roles in the circadian oscillation of arylalkylamine N-acetyltransferase mRNA in chicken cone photoreceptors."
      Haque R. , Ali F.G. , Biscoglia R. , Abey J. , Weller J. , Klein D. , Iuvone P.M.
      J. Neurochem.113:1296-1306(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;TISSUE SPECIFICITY
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