NPAS2 ELISA Kit for Human(Homo sapiens) | EIAab.comNPAS2 ELISA Kit for Human(Homo sapiens)

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NPAS2 (Gene name),

Neuronal PAS domain-containing protein 2 (Protein name ), NPAS2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NPAS2(BHLHE9;MOP4;PASD4);

Protein name:

Neuronal PAS domain-containing protein 2(Neuronal PAS2);

Alternative:

Class E basic helix-loop-helix protein 9(bHLHe9);Basic-helix-loop-helix-PAS protein MOP4;PAS domain-containing protein 4;Member of PAS protein 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent transactivation.

Function:

BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

824

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

824:

PQPLRPPRRV | SSLSESSGLQ | QPPR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q99743

UniGene:

Hs.156832

STRING:

9606.ENSP00000338283

SMR:

Q99743

KEGG:

hsa:4862

MIM:

603347

Pfam:

PF00010

Uniprot:

Q99743

FOR

ELISA Kit for Human Neuronal PAS2

Cat.:

E13384h

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Manual:

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96T

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ELISA Kit for Human Neuronal PAS2

Cat.:

E13384c

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MSDS:

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Packing:

96T

ELISA Kit for Human Neuronal PAS2

Cat.:

E13384m

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MSDS:

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Packing:

96T

CLIA Kit for Human Neuronal PAS2

Cat.:

U13384c

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MSDS:

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Packing:

96T

CLIA Kit for Human Neuronal PAS2

Cat.:

U13384h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Neuronal PAS2

Cat.:

U13384m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Neuronal PAS2

Cat.:

P13384Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Neuronal PAS2

Cat.:

P13384Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Neuronal PAS2

Protein for Human Neuronal PAS2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system."
Zhou Y.-D. , Barnard M. , Tian H. , Li X. , Ring H.Z. , Francke U. , Shelton J. , Richardson J. , Russell D.W. , McKnight S.L.
Proc. Natl. Acad. Sci. U.S.A.94:713-718(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ALA-394 AND LEU-471
2.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-394
tissue: Lung.
4.

"Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway."
Hogenesch J.B. , Chan W.K. , Jackiw V.H. , Brown R.C. , Gu Y.-Z. , Pray-Grant M. , Perdew G.H. , Bradfield C.A.
J. Biol. Chem.272:8581-8593(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-626;VARIANT ALA-394
5.

"NPAS2: an analog of clock operative in the mammalian forebrain."
Reick M. , Garcia J.A. , Dudley C. , McKnight S.L.
Science293:506-509(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors."
Rutter J. , Reick M. , Wu L.C. , McKnight S.L.
Science293:510-514(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING
7.

"Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
Curtis A.M. , Seo S.B. , Westgate E.J. , Rudic R.D. , Smyth E.M. , Chakravarti D. , FitzGerald G.A. , McNamara P.
J. Biol. Chem.279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH NCOA3; KAT2B; CREBBP AND EP300
8.

"Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood."
Hampp G. , Ripperger J.A. , Houben T. , Schmutz I. , Blex C. , Perreau-Lenz S. , Brunk I. , Spanagel R. , Ahnert-Hilger G. , Meijer J.H. , Albrecht U.
Curr. Biol.18:678-683(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response."
Hoffman A.E. , Zheng T. , Ba Y. , Zhu Y.
Mol. Cancer Res.6:1461-1468(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Metabolism and the circadian clock converge."
Eckel-Mahan K. , Sassone-Corsi P.
Physiol. Rev.93:107-135(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
11.

"Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference."
Johansson C. , Willeit M. , Smedh C. , Ekholm J. , Paunio T. , Kieseppa T. , Lichtermann D. , Praschak-Rieder N. , Neumeister A. , Nilsson L.G. , Kasper S. , Peltonen L. , Adolfsson R. , Schalling M. , Partonen T.
Neuropsychopharmacology28:734-739(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT LEU-471 WITH SAD
12.

"Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma."
Zhu Y. , Leaderer D. , Guss C. , Brown H.N. , Zhang Y. , Boyle P. , Stevens R.G. , Hoffman A. , Qin Q. , Han X. , Zheng T.
Int. J. Cancer120:432-435(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-394
13.

"Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk."
Zhu Y. , Stevens R.G. , Leaderer D. , Hoffman A. , Holford T. , Zhang Y. , Brown H.N. , Zheng T.
Breast Cancer Res. Treat.107:421-425(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-394

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