Npas2 ELISA Kit for Mouse(Mus musculus) | EIAab.comNpas2 ELISA Kit for Mouse(Mus musculus)

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Npas2 (Gene name),

Neuronal PAS domain-containing protein 2 (Protein name ), NPAS2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Npas2;

Protein name:

Neuronal PAS domain-containing protein 2(Neuronal PAS2);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent transactivation.

Function:

BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

816

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

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650:

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750:

800:

816:

PQPPRPSRRV | SRLSES

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.2380

KEGG:

mmu:18143

SMR:

P97460

String:

P97460

Pfam:

PF00010

Uniprot:

P97460

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ELISA Kit for Mouse Neuronal PAS2

Cat.:

E13384h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse Neuronal PAS2

Cat.:

E13384c

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Neuronal PAS2

Cat.:

E13384m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Neuronal PAS2

Cat.:

U13384c

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Neuronal PAS2

Cat.:

U13384h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Neuronal PAS2

Cat.:

U13384m

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Packing:

96T

Polyclonal Antibody for Mouse Neuronal PAS2

Cat.:

P13384Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Neuronal PAS2

Cat.:

P13384Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Neuronal PAS2

Protein for Mouse Neuronal PAS2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system."
Zhou Y.-D. , Barnard M. , Tian H. , Li X. , Ring H.Z. , Francke U. , Shelton J. , Richardson J. , Russell D.W. , McKnight S.L.
Proc. Natl. Acad. Sci. U.S.A.94:713-718(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
tissue: Brain.
2.

"Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice."
Dudley C.A. , Erbel-Sieler C. , Estill S.J. , Reick M. , Franken P. , Pitts S. , McKnight S.L.
Science301:379-383(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
3.

"Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
Curtis A.M. , Seo S.B. , Westgate E.J. , Rudic R.D. , Smyth E.M. , Chakravarti D. , FitzGerald G.A. , McNamara P.
J. Biol. Chem.279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EP300;INDUCTION
4.

"CO-dependent activity-controlling mechanism of heme-containing CO-sensor protein, neuronal PAS domain protein 2."
Uchida T. , Sato E. , Sato A. , Sagami I. , Shimizu T. , Kitagawa T.
J. Biol. Chem.280:21358-21368(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEME-BINDING;RESONANCE RAMAN SPECTROSCOPY;ENZYME REGULATION
5.

"Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES."
Kondratov R.V. , Kondratova A.A. , Lee C. , Gorbacheva V.Y. , Chernov M.V. , Antoch M.P.
Cell Cycle5:890-895(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARNTL/BMAL1;FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION
6.

"NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions."
Franken P. , Dudley C.A. , Estill S.J. , Barakat M. , Thomason R. , O'Hara B.F. , McKnight S.L.
Proc. Natl. Acad. Sci. U.S.A.103:7118-7123(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
7.

"CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock."
DeBruyne J.P. , Weaver D.R. , Reppert S.M.
Nat. Neurosci.10:543-545(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
8.

"Effects of mutations in the heme domain on the transcriptional activity and DNA-binding activity of NPAS2."
Ishida M. , Ueha T. , Sagami I.
Biochem. Biophys. Res. Commun.368:292-297(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;MUTAGENESIS OF HIS-119 AND HIS-171
9.

"Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood."
Hampp G. , Ripperger J.A. , Houben T. , Schmutz I. , Blex C. , Perreau-Lenz S. , Brunk I. , Spanagel R. , Ahnert-Hilger G. , Meijer J.H. , Albrecht U.
Curr. Biol.18:678-683(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system."
Debruyne J.P.
J. Genet.87:437-446(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
11.

"Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators."
Bertolucci C. , Cavallari N. , Colognesi I. , Aguzzi J. , Chen Z. , Caruso P. , Foa A. , Tosini G. , Bernardi F. , Pinotti M.
Mol. Cell. Biol.28:3070-3075(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"NPAS2 deletion impairs responses to restricted feeding but not to metabolic challenges."
Wu X. , Wiater M.F. , Ritter S.
Physiol. Behav.99:466-471(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
13.

"Effects of the bHLH domain on axial coordination of heme in the PAS-A domain of neuronal PAS domain protein 2 (NPAS2): conversion from His119/Cys170 coordination to His119/His171 coordination."
Uchida T. , Sagami I. , Shimizu T. , Ishimori K. , Kitagawa T.
J. Inorg. Biochem.108:188-195(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEME-BINDING;RESONANCE RAMAN SPECTROSCOPY
14.

"Effects of NAD(P)H and its derivatives on the DNA-binding activity of NPAS2, a mammalian circadian transcription factor."
Yoshii K. , Ishijima S. , Sagami I.
Biochem. Biophys. Res. Commun.437:386-391(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;ENZYME REGULATION
15.

"Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells."
Hwang C.K. , Chaurasia S.S. , Jackson C.R. , Chan G.C. , Storm D.R. , Iuvone P.M.
J. Neurosci.33:14989-14997(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;INDUCTION
16.

"Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model."
O'Neil D. , Mendez-Figueroa H. , Mistretta T.A. , Su C. , Lane R.H. , Aagaard K.M.
Mol. Genet. Metab.110:378-387(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE

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