Gene name:
Nr1h2 (Lxrb;Rip15;Unr;Unr2) ;
Protein name:
Oxysterols receptor LXR-beta ;
Alternative:
Nuclear receptor subfamily 1 group H member 2 ;Liver X receptor beta ;Ubiquitously-expressed nuclear receptor ;Retinoid X receptor-interacting protein No.15 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms a heterodimer with RXR.
Function:
Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSSPTSSLDT | PVPGNGSPQP | STSATSPTIK | EEGQETDPPP | GSEGSSSAYI |
100:
VVILEPEDEP | ERKRKKGPAP | KMLGHELCRV | CGDKASGFHY | NVLSCEGCKG |
150:
FFRRSVVHGG | AGRYACRGSG | TCQMDAFMRR | KCQLCRLRKC | KEAGMREQCV |
200:
LSEEQIRKKR | IQKQQQQQPP | PPSEPAASSS | GRPAASPGTS | EASSQGSGEG |
250:
EGIQLTAAQE | LMIQQLVAAQ | LQCNKRSFSD | QPKVTPWPLG | ADPQSRDARQ |
300:
QRFAHFTELA | IISVQEIVDF | AKQVPGFLQL | GREDQIALLK | ASTIEIMLLE |
350:
TARRYNHETE | CITFLKDFTY | SKDDFHRAGL | QVEFINPIFE | FSRAMRRLGL |
400:
DDAEYALLIA | INIFSADRPN | VQEPSRVEAL | QQPYVEALLS | YTRIKRPQDQ |
446:
LRFPRMLMKL | VSLRTLSSVH | SEQVFALRLQ | DKKLPPLLSE | IWDVHE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
ELISA Kit for Mouse Oxysterols receptor LXR-beta
ELISA Kit for Mouse Oxysterols receptor LXR-beta
ELISA Kit for Mouse Oxysterols receptor LXR-beta
ELISA Kit for Mouse Oxysterols receptor LXR-beta
CLIA Kit for Mouse Oxysterols receptor LXR-beta
CLIA Kit for Mouse Oxysterols receptor LXR-beta
CLIA Kit for Mouse Oxysterols receptor LXR-beta
CLIA Kit for Mouse Oxysterols receptor LXR-beta
Polyclonal Antibody for Mouse Oxysterols receptor LXR-beta
Polyclonal Antibody for Mouse Oxysterols receptor LXR-beta
Polyclonal Antibody for Mouse Oxysterols receptor LXR-beta
Polyclonal Antibody for Mouse Oxysterols receptor LXR-beta
Monoclonal Antibody for Mouse Oxysterols receptor LXR-beta
Monoclonal Antibody for Mouse Oxysterols receptor LXR-beta
Monoclonal Antibody for Mouse Oxysterols receptor LXR-beta
Monoclonal Antibody for Mouse Oxysterols receptor LXR-beta
Protein for Mouse Oxysterols receptor LXR-beta
Protein for Mouse Oxysterols receptor LXR-beta
Protein for Mouse Oxysterols receptor LXR-beta
Protein for Mouse Oxysterols receptor LXR-beta
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
129/SvJ .
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
4.
"Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
Wada T.
,
Kang H.S.
,
Angers M.
,
Gong H.
,
Bhatia S.
,
Khadem S.
,
Ren S.
,
Ellis E.
,
Strom S.C.
,
Jetten A.M.
,
Xie W.
Mol. Pharmacol.73:891-899(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN METABOLISM REGULATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
"The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
Hong C.
,
Duit S.
,
Jalonen P.
,
Out R.
,
Scheer L.
,
Sorrentino V.
,
Boyadjian R.
,
Rodenburg K.W.
,
Foley E.
,
Korhonen L.
,
Lindholm D.
,
Nimpf J.
,
van Berkel T.J.
,
Tontonoz P.
,
Zelcer N.
J. Biol. Chem.285:19720-19726(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION