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Index > Protein center > NR2C1(Gene name) > Human
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  • NR2C1 (Gene name),
  • Nuclear receptor subfamily 2 group C member 1 (Protein name ),  NR2C1_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    NR2C1(TR2);
    Protein name:
    Nuclear receptor subfamily 2 group C member 1;
    Alternative:
    Testicular receptor 2;Orphan nuclear receptor TR2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C2 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain). Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth.
    Function:
    Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
    Subcellular Location:
    Nucleus Nucleus PML body Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation.
    Protein Attributes:
    Sequence length:
    603
    Sequence:
    50:
    MATIEEIAHQ | IIEQQMGEIV | TEQQTGQKIQ | IVTALDHNTQ | GKQFILTNHD | 
    100:
    GSTPSKVILA | RQDSTPGKVF | LTTPDAAGVN | QLFFTTPDLS | AQHLQLLTDN | 
    150:
    SPDQGPNKVF | DLCVVCGDKA | SGRHYGAVTC | EGCKGFFKRS | IRKNLVYSCR | 
    200:
    GSKDCIINKH | HRNRCQYCRL | QRCIAFGMKQ | DSVQCERKPI | EVSREKSSNC | 
    250:
    AASTEKIYIR | KDLRSPLTAT | PTFVTDSEST | RSTGLLDSGM | FMNIHPSGVK | 
    300:
    TESAVLMTSD | KAESCQGDLS | TLANVVTSLA | NLGKTKDLSQ | NSNEMSMIES | 
    350:
    LSNDDTSLCE | FQEMQTNGDV | SRAFDTLAKA | LNPGESTACQ | SSVAGMEGSV | 
    400:
    HLITGDSSIN | YTEKEGPLLS | DSHVAFRLTM | PSPMPEYLNV | HYIGESASRL | 
    450:
    LFLSMHWALS | IPSFQALGQE | NSISLVKAYW | NELFTLGLAQ | CWQVMNVATI | 
    500:
    LATFVNCLHN | SLQQDKMSTE | RRKLLMEHIF | KLQEFCNSMV | KLCIDGYEYA | 
    550:
    YLKAIVLFSP | DHPSLENMEQ | IEKFQEKAYV | EFQDYITKTY | PDDTYRLSRL | 
    600:
    LLRLPALRLM | NATITEELFF | KGLIGNIRID | SVIPHILKME | PADYNSQIIG | 
    603:
    HSI
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Nuclear receptor subfamily 2 group C member 1
    ELISA Kit for Human Nuclear receptor subfamily 2 group C member 1
    ELISA Kit for Human Nuclear receptor subfamily 2 group C member 1
    ELISA Kit for Human Nuclear receptor subfamily 2 group C member 1
    CLIA Kit for Human Nuclear receptor subfamily 2 group C member 1
    CLIA Kit for Human Nuclear receptor subfamily 2 group C member 1
    CLIA Kit for Human Nuclear receptor subfamily 2 group C member 1
    CLIA Kit for Human Nuclear receptor subfamily 2 group C member 1
    Polyclonal Antibody for Human Nuclear receptor subfamily 2 group C member 1
    Polyclonal Antibody for Human Nuclear receptor subfamily 2 group C member 1
    Polyclonal Antibody for Human Nuclear receptor subfamily 2 group C member 1
    Polyclonal Antibody for Human Nuclear receptor subfamily 2 group C member 1
    Monoclonal Antibody for Human Nuclear receptor subfamily 2 group C member 1
    Monoclonal Antibody for Human Nuclear receptor subfamily 2 group C member 1
    Monoclonal Antibody for Human Nuclear receptor subfamily 2 group C member 1
    Monoclonal Antibody for Human Nuclear receptor subfamily 2 group C member 1
    Protein for Human Nuclear receptor subfamily 2 group C member 1
    Protein for Human Nuclear receptor subfamily 2 group C member 1
    Protein for Human Nuclear receptor subfamily 2 group C member 1
    Protein for Human Nuclear receptor subfamily 2 group C member 1

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    References
    1. 1.
      "Identification of a new member of the steroid receptor super-family by cloning and sequence analysis."
      Chang C. , Kokontis J.
      Biochem. Biophys. Res. Commun.155:971-977(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      tissue: Testis.
    2. 2.
      "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains."
      Chang C. , Kokontis J. , Acakpo-Satchivi L. , Liao S. , Takeda H. , Chang Y.
      Biochem. Biophys. Res. Commun.165:735-741(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Tongue.
    4. 4.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Colon.
    7. 7.
      "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor."
      Hu Y.C. , Shyr C.R. , Che W. , Mu X.M. , Kim E. , Chang C.
      J. Biol. Chem.277:33571-33579(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ESR1
    8. 8.
      "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A."
      Lin Y.L. , Wang Y.H. , Lee H.J.
      Biochem. Biophys. Res. Commun.350:430-436(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215 AND THR-220;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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