Nr2c1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comNr2c1 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Nr2c1(Gene name) > Rat

Nr2c1 (Gene name),

Nuclear receptor subfamily 2 group C member 1 (Protein name ), NR2C1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Nr2c1(Tr2);

Protein name:

Nuclear receptor subfamily 2 group C member 1;

Alternative:

Testicular receptor 2;Orphan nuclear receptor TR2;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer (By similarity). Heterodimer; with NR2C2 which is required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain); the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression.

Function:

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.

Subcellular Location:

Nucleus Nucleus PML body Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-210 phosphorylation, to PML bodies for subsequent sumoylation.

Protein Attributes:

Sequence length:

590

Sequence:

50:

100:

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250:

300:

350:

400:

450:

500:

550:

590:

ITEELFFKGL | IGNVRIDSVI | PHILKMEPAD | YNSQIIGHSL |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00104

String:

Q8VIJ4

SMR:

Q8VIJ4

UniGene:

Rn.79894

KEGG:

rno:252924

Uniprot:

Q8VIJ4

FOR

ELISA Kit for Rat Nuclear receptor subfamily 2 group C member 1

CLIA Kit for Rat Nuclear receptor subfamily 2 group C member 1

Polyclonal Antibody for Rat Nuclear receptor subfamily 2 group C member 1

Monoclonal Antibody for Rat Nuclear receptor subfamily 2 group C member 1

Protein for Rat Nuclear receptor subfamily 2 group C member 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Gene expression of the androgen repressed rat TR2 orphan receptor: a member of steroid receptor superfamily."
Ideta R. , Adachi K. , Takeda H. , Chang C. , Yeh S. , Lee Y. , Su C.
Endocr. J.3:277-283(1995)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Testis.
2.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: Brown Norway.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Prostate.

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