Gene name:
Slc11a2 (Dct1;Dmt1;Nramp2) ;
Protein name:
Natural resistance-associated macrophage protein 2 (NRAMP 2) ;
Alternative:
Divalent metal transporter 1 (DMT-1) ;Divalent cation transporter 1 ;Solute carrier family 11 member 2 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome-dependent degradation. Interacts with NDFIP2.
Function:
Important in metal transport, in particular iron. Can also transport zinc, manganese, cobalt, cadmium, copper, nickel and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.
Subcellular Location:
Endosome membrane
Multi-pass membrane protein
Protein Attributes:
50:
MVLDPEEKIP | DDGASGDHGD | SASLGAINPA | YSNSSLPHST | GDSEEPFTTY |
100:
FDEKIPIPEE | EYSCFSFRKL | WAFTGPGFLM | SIAYLDPGNI | ESDLQSGAVA |
150:
GFKLLWVLLL | ATIVGLLLQR | LAARLGVVTG | LHLAEVCHRQ | YPKVPRIILW |
200:
LMVELAIIGS | DMQEVIGSAI | AINLLSAGRV | PLYGGVLITI | ADTFVFLFLD |
250:
KYGLRKLEAF | FGFLITIMAL | TFGYEYVTVK | PSQSQVLRGM | FVPSCSGCHT |
300:
PQVEQAVGIV | GAVIMPHNMY | LHSALVKSRQ | VNRANKQEVR | EANKYFFIES |
350:
CIALFVSFII | NVFVVSVFAE | AFFEKTNEQV | VEVCRNSSSP | HADLFPNDNS |
400:
TLAVDIYKGG | VVLGCYFGPA | ALYIWAVGIL | AAGQSSTMTG | TYSGQFVMEG |
450:
FLNLKWSRFA | RVILTRSIAI | IPTLLVAVFQ | DVEHLTGMND | FLNVLQSLQL |
500:
PFALIPILTF | TSLRPVMSEF | SNGIGWRIAG | GILVLLVCSI | NMYFVVVYVQ |
550:
ELGHVALYVV | AAVVSVAYLG | FVFYLGWQCL | IALGLSFLDC | GRSYHLGLTA |
568:
RPEIYLLNTV | DAVSLVSR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Rat NRAMP 2
ELISA Kit for Rat NRAMP 2
ELISA Kit for Rat NRAMP 2
Polyclonal Antibody for Rat NRAMP 2
Polyclonal Antibody for Rat NRAMP 2
Polyclonal Antibody for Rat NRAMP 2
Monoclonal Antibody for Rat NRAMP 2
Monoclonal Antibody for Rat NRAMP 2
Monoclonal Antibody for Rat NRAMP 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
strain :
Sprague-Dawley .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Cerebellum .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT B ARG-185