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Index > Protein center > NRG3(Gene name) > Human
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  • NRG3 (Gene name),
  • Pro-neuregulin-3, membrane-bound isoform (Protein name ),  NRG3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NRG3;
    Protein name:
    Pro-neuregulin-3, membrane-bound isoform(Pro-NRG3);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
    Subcellular Location:
    Isoform 3 Cell membrane Single-pass type I membrane protein Isoform 3 is also proteolytically released as a soluble form.
    Protein Attributes:
    Sequence length:
    720
    Sequence:
    50:
    MSEGAAAASP | PGAASAAAAS | AEEGTAAAAA | AAAAGGGPDG | GGEGAAEPPR | 
    100:
    ELRCSDCIVW | NRQQTWLCVV | PLFIGFIGLG | LSLMLLKWIV | VGSVKEYVPT | 
    150:
    DLVDSKGMGQ | DPFFLSKPSS | FPKAMETTTT | TTSTTSPATP | SAGGAASSRT | 
    200:
    PNRISTRLTT | ITRAPTRFPG | HRVPIRASPR | STTARNTAAP | ATVPSTTAPF | 
    250:
    FSSSTLGSRP | PVPGTPSTQA | MPSWPTAAYA | TSSYLHDSTP | SWTLSPFQDA | 
    300:
    ASSSSSSSSS | ATTTTPETST | SPKFHTTTYS | TERSEHFKPC | RDKDLAYCLN | 
    350:
    DGECFVIETL | TGSHKHCRCK | EGYQGVRCDQ | FLPKTDSILS | DPTDHLGIEF | 
    400:
    MESEEVYQRQ | VLSISCIIFG | IVIVGMFCAA | FYFKSKKQAK | QIQEQLKVPQ | 
    450:
    NGKSYSLKAS | STMAKSENLV | KSHVQLQNYS | KVERHPVTAL | EKMMESSFVG | 
    500:
    PQSFPEVPSP | DRGSQSVKHH | RSLSSCCSPG | QRSGMLHRNA | FRRTPPSPRS | 
    550:
    RLGGIVGPAY | QQLEESRIPD | QDTIPCQGIE | VRKTISHLPI | QLWCVERPLD | 
    600:
    LKYSSSGLKT | QRNTSINMQL | PSRETNPYFN | SLEQKDLVGY | SSTRASSVPI | 
    650:
    IPSVGLEETC | LQMPGISEVK | SIKWCKNSYS | ADVVNVSIPV | SDCLIAEQQE | 
    700:
    VKILLETVQE | QIRILTDARR | SEDYELASVE | TEDSASENTA | FLPLSPTAKS | 
    720:
    EREAQFVLRN | EIQRDSALTK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Pro-NRG3
    ELISA Kit for Human Pro-NRG3
    CLIA Kit for Human Pro-NRG3
    CLIA Kit for Human Pro-NRG3
    Polyclonal Antibody for Human Pro-NRG3
    Polyclonal Antibody for Human Pro-NRG3
    Monoclonal Antibody for Human Pro-NRG3
    Monoclonal Antibody for Human Pro-NRG3
    Protein for Human Pro-NRG3
    Protein for Human Pro-NRG3

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4."
      Zhang D. , Sliwkowski M.X. , Mark M. , Frantz G. , Akita R. , Sun Y. , Hillan K. , Crowley C. , Brush J. , Godowski P.J.
      Proc. Natl. Acad. Sci. U.S.A.94:9562-9567(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
      tissue: Fetal brain.
    2. 2.
      "Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival."
      Carteron C. , Ferrer-Montiel A.V. , Cabedo H.
      J. Cell Sci.119:898-909(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION;GLYCOSYLATION;FUNCTION
      tissue: Fetal brain.
    3. 3.
      "Bi-directional signalling by NRG-3 cytoplasmic domain."
      Tiao J.Y. , Busfield S.J.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    4. 4.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Ligand discrimination in signaling through an ErbB4 receptor homodimer."
      Sweeney C. , Lai C. , Riese D.J. II , Diamonti A.J. , Cantley L.C. , Carraway K.L. III
      J. Biol. Chem.275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERBB4
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