Protein name:
Pro-neuregulin-3, membrane-bound isoform (Pro-NRG3) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Function:
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Subcellular Location:
Isoform 3
Cell membrane
Single-pass type I membrane protein
Isoform 3 is also proteolytically released as a soluble form.
Protein Attributes:
50:
MSEGAAAASP | PGAASAAAAS | AEEGTAAAAA | AAAAGGGPDG | GGEGAAEPPR |
100:
ELRCSDCIVW | NRQQTWLCVV | PLFIGFIGLG | LSLMLLKWIV | VGSVKEYVPT |
150:
DLVDSKGMGQ | DPFFLSKPSS | FPKAMETTTT | TTSTTSPATP | SAGGAASSRT |
200:
PNRISTRLTT | ITRAPTRFPG | HRVPIRASPR | STTARNTAAP | ATVPSTTAPF |
250:
FSSSTLGSRP | PVPGTPSTQA | MPSWPTAAYA | TSSYLHDSTP | SWTLSPFQDA |
300:
ASSSSSSSSS | ATTTTPETST | SPKFHTTTYS | TERSEHFKPC | RDKDLAYCLN |
350:
DGECFVIETL | TGSHKHCRCK | EGYQGVRCDQ | FLPKTDSILS | DPTDHLGIEF |
400:
MESEEVYQRQ | VLSISCIIFG | IVIVGMFCAA | FYFKSKKQAK | QIQEQLKVPQ |
450:
NGKSYSLKAS | STMAKSENLV | KSHVQLQNYS | KVERHPVTAL | EKMMESSFVG |
500:
PQSFPEVPSP | DRGSQSVKHH | RSLSSCCSPG | QRSGMLHRNA | FRRTPPSPRS |
550:
RLGGIVGPAY | QQLEESRIPD | QDTIPCQGIE | VRKTISHLPI | QLWCVERPLD |
600:
LKYSSSGLKT | QRNTSINMQL | PSRETNPYFN | SLEQKDLVGY | SSTRASSVPI |
650:
IPSVGLEETC | LQMPGISEVK | SIKWCKNSYS | ADVVNVSIPV | SDCLIAEQQE |
700:
VKILLETVQE | QIRILTDARR | SEDYELASVE | TEDSASENTA | FLPLSPTAKS |
720:
EREAQFVLRN | EIQRDSALTK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Pro-NRG3
ELISA Kit for Human Pro-NRG3
CLIA Kit for Human Pro-NRG3
CLIA Kit for Human Pro-NRG3
Polyclonal Antibody for Human Pro-NRG3
Polyclonal Antibody for Human Pro-NRG3
Monoclonal Antibody for Human Pro-NRG3
Monoclonal Antibody for Human Pro-NRG3
Protein for Human Pro-NRG3
Protein for Human Pro-NRG3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
tissue :
Fetal brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION;GLYCOSYLATION;FUNCTION
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ERBB4