Gene name:
IVNS1ABP (HSPC068;ARA3;FLARA3;KIAA0850;NS1;NS1BP) ;
Protein name:
Influenza virus NS1A-binding protein (NS1-BP;NS1-binding protein) ;
Alternative:
Aryl hydrocarbon receptor-associated protein 3 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; through the BTB domain (By similarity). Interacts with NS/Influenza virus NS1A protein and with AHR/Aryl hydrocarbon receptor.
Function:
Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.
Subcellular Location:
Cytoplasm
Cytoplasm
cytoskeleton
Nucleus
nucleoplasm
Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm.
Protein Attributes:
50:
MIPNGYLMFE | DENFIESSVA | KLNALRKSGQ | FCDVRLQVCG | HEMLAHRAVL |
100:
ACCSPYLFEI | FNSDSDPHGI | SHVKFDDLNP | EAVEVLLNYA | YTAQLKADKE |
150:
LVKDVYSAAK | KLKMDRVKQV | CGDYLLSRMD | VTSCISYRNF | ASCMGDSRLL |
200:
NKVDAYIQEH | LLQISEEEEF | LKLPRLKLEV | MLEDNVCLPS | NGKLYTKVIN |
250:
WVQRSIWENG | DSLEELMEEV | QTLYYSADHK | LLDGNLLDGQ | AEVFGSDDDH |
300:
IQFVQKKPPR | ENGHKQISSS | STGCLSSPNA | TVQSPKHEWK | IVASEKTSNN |
350:
TYLCLAVLDG | IFCVIFLHGR | NSPQSSPTST | PKLSKSLSFE | MQQDELIEKP |
400:
MSPMQYARSG | LGTAEMNGKL | IAAGGYNREE | CLRTVECYNP | HTDHWSFLAP |
450:
MRTPRARFQM | AVLMGQLYVV | GGSNGHSDDL | SCGEMYDSNI | DDWIPVPELR |
500:
TNRCNAGVCA | LNGKLYIVGG | SDPYGQKGLK | NCDVFDPVTK | LWTSCAPLNI |
550:
RRHQSAVCEL | GGYLYIIGGA | ESWNCLNTVE | RYNPENNTWT | LIAPMNVARR |
600:
GAGVAVLNGK | LFVCGGFDGS | HAISCVEMYD | PTRNEWKMMG | NMTSPRSNAG |
642:
IATVGNTIYA | VGGFDGNEFL | NTVEVYNLES | NEWSPYTKIF | QF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human NS1-BP
ELISA Kit for Human NS1-BP
CLIA Kit for Human NS1-BP
CLIA Kit for Human NS1-BP
Polyclonal Antibody for Human NS1-BP
Polyclonal Antibody for Human NS1-BP
Monoclonal Antibody for Human NS1-BP
Monoclonal Antibody for Human NS1-BP
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277 AND SER-322;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336 AND SER-338;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]