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Index > Protein center > Nsd1(Gene name) > Mouse
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  • Nsd1 (Gene name),
  • Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (Protein name ),  NSD1_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Nsd1;
    Protein name:
    Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific;
    Alternative:
    H4-K20-HMTase;H3-K36-HMTase;Nuclear receptor-binding SET domain-containing protein 1(NR-binding SET domain-containing protein);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with AR DNA- and ligand-binding domains (By similarity). Interacts with the ligand-binding domains of RARA and THRA in the absence of ligand; in the presence of ligand the interaction is severely disrupted but some binding still occurs. Interacts with the ligand-binding domains of RXRA and ESRRA only in the presence of ligand. Interacts with ZNF496.
    Function:
    Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development.
    Subcellular Location:
    Nucleus Chromosome
    Protein Attributes:
    Sequence length:
    2588
    Sequence:
    50:
    MDRTCELSRR | NCLLSFSNPV | NLDASEDKDS | PFGNGQSNFS | EPLNGCTMQL | 
    100:
    PTAASGTSQN | AYGQDSPSCY | IPLRRLQDLA | SMINVEYLSG | SADGSESFQD | 
    150:
    PAKSDSRAQS | PIVCTSLSPG | GPTALAMKQE | PTCNNSPELQ | LRVTKTTKNG | 
    200:
    FLHFENFTGV | DDADVDSEMD | PEQPVTEDES | IEEIFEETQT | NATCNYEPKS | 
    250:
    ENGVEVAMGS | EQDSMPESRH | GAVERPFLPL | APQTEKQKNK | QRSEVDGSNE | 
    300:
    KTALLPAPTS | LGDTNVTVEE | QFNSINLSFQ | DDPDSSPSPL | GNMLEIPGTS | 
    350:
    SPSTSQELPF | VPQKILSKWE | ASVGLAEQYD | VPKGSKNQKC | VSSSVKLDSE | 
    400:
    EDMPFEDCTN | DPDSEHLLLN | GCLKSLAFDS | EHSADEKEKP | CAKSRVRKSS | 
    450:
    DNIKRTSVKK | DLVPFESRKE | ERRGKIPDNL | GLDFISGGVS | DKQASNELSR | 
    500:
    IANSLTGSST | APGSFLFSSS | VQNTAKTDFE | TPDCDSLSGL | SESALISKHS | 
    550:
    GEKKKLHPGQ | VCSSKVQLCY | VGAGDEEKRS | NSVSVSTTSD | DGCSDLDPTE | 
    600:
    HNSGFQNSVL | GITDAFDKTE | NALSVHKNET | QYSRYPVTNR | IKEKQKSLIT | 
    650:
    NSHADHLMGS | TKTMEPETAE | LSQVNLSDLK | ISSPIPKPQP | EFRNDGLTTK | 
    700:
    FSAPPGIRNE | NPLTKGGLAN | QTLLPLKCRQ | PKFRSIKCKH | KESPAVAETS | 
    750:
    ATSEDLSLKC | CSSDTNGSPL | ANISKSGKGE | GLKLLNNMHE | KTRDSSDIET | 
    800:
    AVVKHVLSEL | KELSYRSLSE | DVSDSGTAKA | SKPLLFSSAS | SQNHIPIEPD | 
    850:
    YKFSTLLMML | KDMHDSKTKE | QRLMTAQNLA | SYRTPDRGDC | SSGSPVGTSK | 
    900:
    VLVLGSSTPN | SEKPGDSTQD | SVHQSPGGGD | SALSGELSSS | LSSLASDKRE | 
    950:
    LPACGKIRSN | CIPRRNCGRA | KPSSKLRETI | SAQMVKPSVN | PKALKTERKR | 
    1000:
    KFSRLPAVTL | AANRLGNKES | GSVNGPSRGG | AEDPGKEEPL | QQMDLLRNED | 
    1050:
    THFSDVHFDS | KAKQSDPDKN | LEKEPSFENR | KGPELGSEMN | TENDELHGVN | 
    1100:
    QVVPKKRWQR | LNQRRPKPGK | RANRFREKEN | SEGAFGVLLP | ADAVQKARED | 
    1150:
    YLEQRAPPTS | KPEDSAADPN | HGSHSESVAP | RLNVCEKSSV | GMGDVEKETG | 
    1200:
    IPSLMPQTKL | PEPAIRSEKK | RLRKPSKWLL | EYTEEYDQIF | APKKKQKKVQ | 
    1250:
    EQVHKVSSRC | EDESLLARCQ | PSAQNKQVDE | NSLISTKEEP | PVLEREAPFL | 
    1300:
    EGPLAQSDLG | VTHAELPQLT | LSVPVAPEAS | PRPALESEEL | LVKTPGNYES | 
    1350:
    KRQRKPTKKL | LESNDLDPGF | MPKKGDLGLS | RKCFEASRSG | NGIVESRATS | 
    1400:
    HLKEFSGGTT | KIFDKPRKRK | RQRLVTARVH | YKKVKKEDLT | KDTPSSEGEL | 
    1450:
    LIHRTAASPK | EILEEGVEHD | PGMSASKKLQ | VERGGGAALK | ENVCQNCEKL | 
    1500:
    GELLLCEAQC | CGAFHLECLG | LPEMPRGKFI | CNECHTGIHT | CFVCKQSGED | 
    1550:
    VKRCLLPLCG | KFYHEECVQK | YPPTVTQNKG | FRCPLHICIT | CHAANPANVS | 
    1600:
    ASKGRLMRCV | RCPVAYHAND | FCLAAGSKIL | ASNSIICPNH | FTPRRGCRNH | 
    1650:
    EHVNVSWCFV | CSEGGSLLCC | DSCPAAFHRE | CLNIDIPEGN | WYCNDCKAGK | 
    1700:
    KPHYREIVWV | KVGRYRWWPA | EICHPRAVPS | NIDKMRHDVG | EFPVLFFGSN | 
    1750:
    DYLWTHQARV | FPYMEGDVSS | KDKMGKGVDG | TYKKALQEAA | ARFEELKARK | 
    1800:
    ELRQLQEDRK | NDKKPPPYKH | IKVNRPIGRV | QIFTADLSEI | PRCNCKATDE | 
    1850:
    NPCGIDSECI | NRMLLYECHP | TVCPAGVRCQ | NQCFSKRQYP | DVEIFRTLQR | 
    1900:
    GWGLRTKTDI | KKGEFVNEYV | GELIDEEECR | ARIRYAQEHD | ITNFYMLTLD | 
    1950:
    KDRIIDAGPK | GNYARFMNHC | CQPNCETQKW | SVNGDTRVGL | FALSDIKAGT | 
    2000:
    ELTFNYNLEC | LGNGKTVCKC | GAPNCSGFLG | VRPKNQPIVT | EEKSRKFKRK | 
    2050:
    PHGKRRSQGE | VTKEREDECF | SCGDAGQLVS | CKKPGCPKVY | HADCLNLTKR | 
    2100:
    PAGKWECPWH | QCDVCGKEAA | SFCEMCPSSF | CKQHREGMLF | ISKLDGRLSC | 
    2150:
    TEHDPCGPNP | LEPGEIREYV | PPTATSPPSP | GTQPKEQSSE | MATQGPKKSD | 
    2200:
    QPPTDATQLL | PLSKKALTGS | CQRPLLPERP | PERTDSSSHL | LDRIRDLAGS | 
    2250:
    GTKSQSLVSS | QRPQDRPPAK | EGPRPQPPDR | ASPMTRPSSS | PSVSSLPLER | 
    2300:
    PLRMTDSRLD | KSIGAASPKS | QAVEKTPAST | GLRLSSPDRL | LTTNSPKPQI | 
    2350:
    SDRPPEKSHA | SLTQRLPPPE | KVLSAVVQSL | VAKEKALRPV | DQNTQSKHRP | 
    2400:
    AVVMDLIDLT | PRQKERAASP | QEVTPQADEK | TAMLESSSWP | SSKGLGHIPR | 
    2450:
    ATEKISVSES | LQPSGKVAAP | SEHPWQAVKS | LTHARFLSPP | SAKAFLYESA | 
    2500:
    TQASGRTPVG | AEQTPGPPSP | APGLVKQVKQ | LSRGLTAKSG | QSFRSLGKIS | 
    2550:
    ASLPNEEKKL | TTTEQSPWGL | GKASPGAGLW | PIVAGQTLAQ | ACWSAGGTQT | 
    2588:
    LAQTCWSLGR | GQDPKPENAI | QALNQAPSSR | KCADSEKK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    ELISA Kit for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    CLIA Kit for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    CLIA Kit for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    Polyclonal Antibody for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    Polyclonal Antibody for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    Monoclonal Antibody for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    Monoclonal Antibody for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    Protein for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    Protein for Mouse Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators."
      Huang N. , vom Baur E. , Garnier J.-M. , Lerouge T. , Vonesch J.-L. , Lutz Y. , Chambon P. , Losson R.
      EMBO J.17:3398-3412(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH RARA; THRA; RXRA AND ESRRA;SUBCELLULAR LOCATION;MUTAGENESIS OF PHE-803; 804-SER-THR-805 AND 806-LEU-LEU-807
      tissue: Embryo.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2220-2588
      strain: C57BL/6J.
      tissue: Embryo.
    3. 3.
      "NSD1 is essential for early post-implantation development and has a catalytically active SET domain."
      Rayasam G.V. , Wendling O. , Angrand P.-O. , Mark M. , Niederreither K. , Song L. , Lerouge T. , Hager G.L. , Chambon P. , Losson R.
      EMBO J.22:3153-3163(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;TISSUE SPECIFICITY;MUTAGENESIS OF CYS-1920 AND THR-1950
    4. 4.
      "Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif."
      Nielsen A.L. , Jorgensen P. , Lerouge T. , Cervino M. , Chambon P. , Losson R.
      Mol. Cell. Biol.24:5184-5196(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF496
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