Protein name:
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific;
Alternative:
H4-K20-HMTase;H3-K36-HMTase;Nuclear receptor-binding SET domain-containing protein 1(NR-binding SET domain-containing protein);
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with AR DNA- and ligand-binding domains (By similarity). Interacts with the ligand-binding domains of RARA and THRA in the absence of ligand; in the presence of ligand the interaction is severely disrupted but some binding still occurs. Interacts with the ligand-binding domains of RXRA and ESRRA only in the presence of ligand. Interacts with ZNF496.
Function:
Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development.
Subcellular Location:
Nucleus
Chromosome
Protein Attributes:
50:
MDRTCELSRR | NCLLSFSNPV | NLDASEDKDS | PFGNGQSNFS | EPLNGCTMQL |
100:
PTAASGTSQN | AYGQDSPSCY | IPLRRLQDLA | SMINVEYLSG | SADGSESFQD |
150:
PAKSDSRAQS | PIVCTSLSPG | GPTALAMKQE | PTCNNSPELQ | LRVTKTTKNG |
200:
FLHFENFTGV | DDADVDSEMD | PEQPVTEDES | IEEIFEETQT | NATCNYEPKS |
250:
ENGVEVAMGS | EQDSMPESRH | GAVERPFLPL | APQTEKQKNK | QRSEVDGSNE |
300:
KTALLPAPTS | LGDTNVTVEE | QFNSINLSFQ | DDPDSSPSPL | GNMLEIPGTS |
350:
SPSTSQELPF | VPQKILSKWE | ASVGLAEQYD | VPKGSKNQKC | VSSSVKLDSE |
400:
EDMPFEDCTN | DPDSEHLLLN | GCLKSLAFDS | EHSADEKEKP | CAKSRVRKSS |
450:
DNIKRTSVKK | DLVPFESRKE | ERRGKIPDNL | GLDFISGGVS | DKQASNELSR |
500:
IANSLTGSST | APGSFLFSSS | VQNTAKTDFE | TPDCDSLSGL | SESALISKHS |
550:
GEKKKLHPGQ | VCSSKVQLCY | VGAGDEEKRS | NSVSVSTTSD | DGCSDLDPTE |
600:
HNSGFQNSVL | GITDAFDKTE | NALSVHKNET | QYSRYPVTNR | IKEKQKSLIT |
650:
NSHADHLMGS | TKTMEPETAE | LSQVNLSDLK | ISSPIPKPQP | EFRNDGLTTK |
700:
FSAPPGIRNE | NPLTKGGLAN | QTLLPLKCRQ | PKFRSIKCKH | KESPAVAETS |
750:
ATSEDLSLKC | CSSDTNGSPL | ANISKSGKGE | GLKLLNNMHE | KTRDSSDIET |
800:
AVVKHVLSEL | KELSYRSLSE | DVSDSGTAKA | SKPLLFSSAS | SQNHIPIEPD |
850:
YKFSTLLMML | KDMHDSKTKE | QRLMTAQNLA | SYRTPDRGDC | SSGSPVGTSK |
900:
VLVLGSSTPN | SEKPGDSTQD | SVHQSPGGGD | SALSGELSSS | LSSLASDKRE |
950:
LPACGKIRSN | CIPRRNCGRA | KPSSKLRETI | SAQMVKPSVN | PKALKTERKR |
1000:
KFSRLPAVTL | AANRLGNKES | GSVNGPSRGG | AEDPGKEEPL | QQMDLLRNED |
1050:
THFSDVHFDS | KAKQSDPDKN | LEKEPSFENR | KGPELGSEMN | TENDELHGVN |
1100:
QVVPKKRWQR | LNQRRPKPGK | RANRFREKEN | SEGAFGVLLP | ADAVQKARED |
1150:
YLEQRAPPTS | KPEDSAADPN | HGSHSESVAP | RLNVCEKSSV | GMGDVEKETG |
1200:
IPSLMPQTKL | PEPAIRSEKK | RLRKPSKWLL | EYTEEYDQIF | APKKKQKKVQ |
1250:
EQVHKVSSRC | EDESLLARCQ | PSAQNKQVDE | NSLISTKEEP | PVLEREAPFL |
1300:
EGPLAQSDLG | VTHAELPQLT | LSVPVAPEAS | PRPALESEEL | LVKTPGNYES |
1350:
KRQRKPTKKL | LESNDLDPGF | MPKKGDLGLS | RKCFEASRSG | NGIVESRATS |
1400:
HLKEFSGGTT | KIFDKPRKRK | RQRLVTARVH | YKKVKKEDLT | KDTPSSEGEL |
1450:
LIHRTAASPK | EILEEGVEHD | PGMSASKKLQ | VERGGGAALK | ENVCQNCEKL |
1500:
GELLLCEAQC | CGAFHLECLG | LPEMPRGKFI | CNECHTGIHT | CFVCKQSGED |
1550:
VKRCLLPLCG | KFYHEECVQK | YPPTVTQNKG | FRCPLHICIT | CHAANPANVS |
1600:
ASKGRLMRCV | RCPVAYHAND | FCLAAGSKIL | ASNSIICPNH | FTPRRGCRNH |
1650:
EHVNVSWCFV | CSEGGSLLCC | DSCPAAFHRE | CLNIDIPEGN | WYCNDCKAGK |
1700:
KPHYREIVWV | KVGRYRWWPA | EICHPRAVPS | NIDKMRHDVG | EFPVLFFGSN |
1750:
DYLWTHQARV | FPYMEGDVSS | KDKMGKGVDG | TYKKALQEAA | ARFEELKARK |
1800:
ELRQLQEDRK | NDKKPPPYKH | IKVNRPIGRV | QIFTADLSEI | PRCNCKATDE |
1850:
NPCGIDSECI | NRMLLYECHP | TVCPAGVRCQ | NQCFSKRQYP | DVEIFRTLQR |
1900:
GWGLRTKTDI | KKGEFVNEYV | GELIDEEECR | ARIRYAQEHD | ITNFYMLTLD |
1950:
KDRIIDAGPK | GNYARFMNHC | CQPNCETQKW | SVNGDTRVGL | FALSDIKAGT |
2000:
ELTFNYNLEC | LGNGKTVCKC | GAPNCSGFLG | VRPKNQPIVT | EEKSRKFKRK |
2050:
PHGKRRSQGE | VTKEREDECF | SCGDAGQLVS | CKKPGCPKVY | HADCLNLTKR |
2100:
PAGKWECPWH | QCDVCGKEAA | SFCEMCPSSF | CKQHREGMLF | ISKLDGRLSC |
2150:
TEHDPCGPNP | LEPGEIREYV | PPTATSPPSP | GTQPKEQSSE | MATQGPKKSD |
2200:
QPPTDATQLL | PLSKKALTGS | CQRPLLPERP | PERTDSSSHL | LDRIRDLAGS |
2250:
GTKSQSLVSS | QRPQDRPPAK | EGPRPQPPDR | ASPMTRPSSS | PSVSSLPLER |
2300:
PLRMTDSRLD | KSIGAASPKS | QAVEKTPAST | GLRLSSPDRL | LTTNSPKPQI |
2350:
SDRPPEKSHA | SLTQRLPPPE | KVLSAVVQSL | VAKEKALRPV | DQNTQSKHRP |
2400:
AVVMDLIDLT | PRQKERAASP | QEVTPQADEK | TAMLESSSWP | SSKGLGHIPR |
2450:
ATEKISVSES | LQPSGKVAAP | SEHPWQAVKS | LTHARFLSPP | SAKAFLYESA |
2500:
TQASGRTPVG | AEQTPGPPSP | APGLVKQVKQ | LSRGLTAKSG | QSFRSLGKIS |
2550:
ASLPNEEKKL | TTTEQSPWGL | GKASPGAGLW | PIVAGQTLAQ | ACWSAGGTQT |
2588:
LAQTCWSLGR | GQDPKPENAI | QALNQAPSSR | KCADSEKK

Vaild Sequence:
Related Databases
Uniprot: