MT-ND6 ELISA Kit for Human(Homo sapiens) | EIAab.comMT-ND6 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MT-ND6(Gene name) > Human

MT-ND6 (Gene name),

NADH-ubiquinone oxidoreductase chain 6 (Protein name ), NU6M_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MT-ND6(MTND6;NADH6;ND6);

Protein name:

NADH-ubiquinone oxidoreductase chain 6;

Alternative:

NADH dehydrogenase subunit 6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular Location:

Mitochondrion membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

174

Sequence:

50:

100:

150:

174:

WLVVVTGWTL | FVGVYIVIEI | ARGN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P03923

Pfam:

PF00499

MIM:

252010

KEGG:

hsa:4541

Uniprot:

P03923

FOR

ELISA Kit for Human NADH-ubiquinone oxidoreductase chain 6

CLIA Kit for Human NADH-ubiquinone oxidoreductase chain 6

Polyclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 6

Monoclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 6

Protein for Human NADH-ubiquinone oxidoreductase chain 6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Sequence and organization of the human mitochondrial genome."
Anderson S. , Bankier A.T. , Barrell B.G. , de Bruijn M.H.L. , Coulson A.R. , Drouin J. , Eperon I.C. , Nierlich D.P. , Roe B.A. , Sanger F. , Schreier P.H. , Smith A.J.H. , Staden R. , Young I.G.
Nature290:457-465(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.

Kogelnik A. , Brown M.
Submitted (1997-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 102; 134 AND 159
3.

"Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs."
Horai S. , Hayasaka K. , Kondo R. , Tsugane K. , Takahata N.
Proc. Natl. Acad. Sci. U.S.A.92:532-536(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
4.

"Leber's hereditary optic neuropathy in Indonesia: two families with the mtDNA 11778G>A and 14484T>C mutations."
Sudoyo H. , Sitepu M. , Malik S. , Poesponegoro H.D. , Marzuki S.
Hum. Mutat. Suppl.1:S271-S274(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LHON VAL-64
5.

"Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J."
Moilanen J.S. , Finnila S. , Majamaa K.
Mol. Biol. Evol.20:2132-2142(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Mitochondrial genome variation and the origin of modern humans."
Ingman M. , Kaessmann H. , Paeaebo S. , Gyllensten U.
Nature408:708-713(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines."
Ingman M. , Gyllensten U.
Genome Res.13:1600-1606(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians."
Coble M.D. , Just R.S. , O'Callaghan J.E. , Letmanyi I.H. , Peterson C.T. , Irwin J.A. , Parsons T.J.
Int. J. Legal Med.118:137-146(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
9.

"Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathy."
Ozawa T. , Tanaka M. , Sugiyama S. , Ino H. , Ohno K. , Hattori K. , Ohbayashi T. , Ito T. , Deguchi H. , Kawamura K. , Nakane Y. , Hashiba K.
Biochem. Biophys. Res. Commun.177:518-525(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-58
10.

"Normal variants of human mitochondrial DNA and translation products: the building of a reference data base."
Marzuki S. , Noer A.S. , Lertrit P. , Thyagarajan D. , Kapsa R. , Utthanaphol P. , Byrne E.
Hum. Genet.88:139-145(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYS-165
11.

"An ND-6 mitochondrial DNA mutation associated with Leber hereditary optic neuropathy."
Johns D.R. , Neufeld M.J. , Park R.D.
Biochem. Biophys. Res. Commun.187:1551-1557(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHON VAL-64
12.

"A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia."
Jun A.S. , Brown M.D. , Wallace D.C.
Proc. Natl. Acad. Sci. U.S.A.91:6206-6210(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LDYT VAL-72
13.

"Genetic and biochemical impairment of mitochondrial complex I activity in a family with Leber hereditary optic neuropathy and hereditary spastic dystonia."
de Vries D.D. , Went L.N. , Bruyn G.W. , Scholte H.R. , Hofstra R.M.W. , Bolhuis P.A. , van Oost B.A.
Am. J. Hum. Genet.58:703-711(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LDYT MET-26
14.

"Leber's hereditary optic neuropathy: clinical and molecular genetic results obtained in a family with a new point mutation at nucleotide position 14498 in the ND 6 gene."
Leo-Kottler B. , Christ-Adler M. , Baumann B. , Zrenner E. , Wissinger B.
Ger. J. Ophthalmol.5:233-240(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHON CYS-59
15.

"Leber's hereditary optic neuropathy: clinical and molecular genetic findings in a patient with a new mutation in the ND6 gene."
Besch D. , Leo-Kottler B. , Zrenner E. , Wissinger B.
Graefes Arch. Clin. Exp. Ophthalmol.237:745-752(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHON SER-36
16.

"The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's hereditary optic neuropathy."
Chinnery P.F. , Brown D.T. , Andrews R.M. , Singh-Kler R. , Riordan-Eva P. , Lindley J. , Applegarth D.A. , Turnbull D.M. , Howell N.
Brain124:209-218(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHON SER-60;VARIANTS ALA-31 AND VAL-33
17.

"An mtDNA mutation, 14453G-->A, in the NADH dehydrogenase subunit 6 associated with severe MELAS syndrome."
Ravn K. , Wibrand F. , Hansen F.J. , Horn N. , Rosenberg T. , Schwartz M.
Eur. J. Hum. Genet.9:805-809(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MELAS VAL-74
18.

"Impaired complex I assembly in a Leigh syndrome patient with a novel missense mutation in the ND6 gene."
Ugalde C. , Triepels R.H. , Coenen M.J. , van den Heuvel L.P. , Smeets R. , Uusimaa J. , Briones P. , Campistol J. , Majamaa K. , Smeitink J.A. , Nijtmans L.G.
Ann. Neurol.54:665-669(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MT-C1D VAL-63
19.

"High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency."
Calvo S.E. , Tucker E.J. , Compton A.G. , Kirby D.M. , Crawford G. , Burtt N.P. , Rivas M. , Guiducci C. , Bruno D.L. , Goldberger O.A. , Redman M.C. , Wiltshire E. , Wilson C.J. , Altshuler D. , Gabriel S.B. , Daly M.J. , Thorburn D.R. , Mootha V.K.
Nat. Genet.42:851-858(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MT-C1D VAL-63 AND VAL-72

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