Oas2 ELISA Kit for Mouse(Mus musculus) | EIAab.comOas2 ELISA Kit for Mouse(Mus musculus)

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Oas2 (Gene name),

2'-5'-oligoadenylate synthase 2 (Protein name ), OAS2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Oas2(oasl11);

Protein name:

2'-5'-oligoadenylate synthase 2((2-5')oligo(A) synthase 2);

Alternative:

2',5'-oligoadenylate synthetase-like 11;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer.

Function:

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.

Subcellular Location:

Cytoplasm Cytoplasm Perinuclear region Mitochondrion Nucleus Microsome Endoplasmic reticulum Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

Protein Attributes:

Sequence length:

742

Sequence:

50:

100:

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450:

500:

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650:

700:

742:

WLSSPCFQVE | QKGLVQPWKV | PVMQTPGSCG | GQIYPTVGGV | TK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

E9Q9A9

Pfam:

PF01909

UniGene:

Mm.260926

STRING:

10090.ENSMUSP00000080209

KEGG:

mmu:246728

Uniprot:

E9Q9A9

FOR

ELISA Kit for Mouse (2-5')oligo(A) synthase 2

CLIA Kit for Mouse (2-5')oligo(A) synthase 2

Polyclonal Antibody for Mouse (2-5')oligo(A) synthase 2

Monoclonal Antibody for Mouse (2-5')oligo(A) synthase 2

Protein for Mouse (2-5')oligo(A) synthase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family."
Kakuta S. , Shibata S. , Iwakura Y.
J. Interferon Cytokine Res.22:981-993(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
strain: C57BL/6J.
tissue: Colon.
2.

"Positional cloning of the murine flavivirus resistance gene."
Perelygin A.A. , Scherbik S.V. , Zhulin I.B. , Stockman B.M. , Li Y. , Brinton M.A.
Proc. Natl. Acad. Sci. U.S.A.99:9322-9327(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT ARG-232
strain: C3H/He.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-232
5.

"The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla."
Perelygin A.A. , Zharkikh A.A. , Scherbik S.V. , Brinton M.A.
J. Mol. Evol.63:562-576(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
6.

"The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities."
Kristiansen H. , Gad H.H. , Eskildsen-Larsen S. , Despres P. , Hartmann R.
J. Interferon Cytokine Res.31:41-47(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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